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MelaNon - Dietary Supplement For Skin Spots, Moles, Etc

Discussion in 'IdeaLabs' started by haidut, Nov 10, 2015.

  1. haidut

    haidut Member

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    Ray has written about several natural compounds that may be helpful for supporting optimal skin health in areas that have moles, spots, blemishes, etc. The natural compounds naringenin and apigenin are the ones most extensively researched for that purpose, but caffeine is also a very beneficial one and already used as part of the SolBan supplement. In addition to supporting skin health, caffeine also helps increase the absorption of both naringenin and apigenin, and that is another reason for its presence in MelaNon.
    The topical doses used in most studies correspond to about 2mg for a human and that applies for both naringenin and apigenin.

    *******************************************************************************
    MelaNon is dietary supplement for skin health. It contains the citrus flavonoid naringenin as well as the flavone apigenin most commonly found in chamomile. MelaNon also contains caffeine for improved estrogen control and skin health. All of the ingredients have been extensively studies for health purposes, but most of the research on naringenin / apigenin focuses on their anti-neoplastic effects, and especially their effects on skin formations such as moles of various types. This product, while consisting entirely of food-grade ingredients, is sanctioned for external use only.

    Servings per container: about 30
    Serving size: 8 drops
    Each serving (8 drops) contains the following ingredients:

    Caffeine - 3mg
    Apigenin - 3mg
    Naringenin - 3mg

    Other ingredients: DMSO, ethanol.
    *******************************************************************************
    References:
    http://www.functionalps.com/blog/2013/1 ... aringenin/
    "...Orange juice contains naringenin which is effective against melanoma, and guavas contain apigenin, also effective. A diet consisting of milk, orange juice, guavas, cheese, and some eggs, liver, and oysters, with aspirin would be protective against the spread of the tumor.”

    http://raypeat.com/articles/articles/th ... trix.shtml
    "...Substances that inhibit inflammation are likely to also inhibit excessive collagen synthesis, serotonin secretion, and the formation of estrogen. Besides aspirin, some effective substances are apigenin and naringenin, found in oranges and guavas. These flavonoids also inhibit the formation of nitric oxide and prostaglandins, which are important for inflammation and carcinogenesis (Liang, et al., 1999). Increased CO2, which has a variety of anti-inflammatory effects, can decrease collagen formation and tissue collagen content significantly (Ryu, et al., 2010)."

    Naringenin:
    http://www.ncbi.nlm.nih.gov/pubmed/21802267
    http://www.ncbi.nlm.nih.gov/pubmed/20857432
    http://www.ncbi.nlm.nih.gov/pubmed/16699821
    http://www.ncbi.nlm.nih.gov/pubmed/21674787
    http://www.ncbi.nlm.nih.gov/pubmed/16794334
    http://www.ncbi.nlm.nih.gov/pubmed/18593176
    http://www.ncbi.nlm.nih.gov/pubmed/26154512
    http://www.ncbi.nlm.nih.gov/pubmed/25514618
    http://www.ncbi.nlm.nih.gov/pubmed/25330158
    http://www.ncbi.nlm.nih.gov/pubmed/25256786
    http://www.ncbi.nlm.nih.gov/pubmed/24311391
    http://www.ncbi.nlm.nih.gov/pubmed/26297636
    http://www.ncbi.nlm.nih.gov/pubmed/26158639
    http://www.ncbi.nlm.nih.gov/pubmed/23933131
    http://www.ncbi.nlm.nih.gov/pubmed/22422675
    http://www.ncbi.nlm.nih.gov/pubmed/18086244
    http://www.ncbi.nlm.nih.gov/pubmed/17886198
    http://www.ncbi.nlm.nih.gov/pubmed/15786488

    Apigenin:
    http://www.ncbi.nlm.nih.gov/pubmed/20306120
    http://www.ncbi.nlm.nih.gov/pubmed/2105157
    http://www.ncbi.nlm.nih.gov/pubmed/24120900
    http://www.ncbi.nlm.nih.gov/pubmed/9066634
    http://www.ncbi.nlm.nih.gov/pubmed/25526033
    http://www.ncbi.nlm.nih.gov/pubmed/24139463
    http://www.ncbi.nlm.nih.gov/pubmed/23304222
    http://www.ncbi.nlm.nih.gov/pubmed/24830944
    http://www.ncbi.nlm.nih.gov/pubmed/23208771
    http://www.ncbi.nlm.nih.gov/pubmed/23161610
    http://www.ncbi.nlm.nih.gov/pubmed/21871547
    http://www.ncbi.nlm.nih.gov/pubmed/23489424
    http://www.ncbi.nlm.nih.gov/pubmed/8968050
    http://www.ncbi.nlm.nih.gov/pubmed/10753197
    http://www.ncbi.nlm.nih.gov/pubmed/16044407
    http://www.ncbi.nlm.nih.gov/pubmed/16982614
    http://www.ncbi.nlm.nih.gov/pubmed/17074806
    http://www.ncbi.nlm.nih.gov/pubmed/18413777
    http://www.ncbi.nlm.nih.gov/pubmed/18993046
    http://www.ncbi.nlm.nih.gov/pubmed/21615506
    http://www.ncbi.nlm.nih.gov/pubmed/24708558
    http://www.ncbi.nlm.nih.gov/pubmed/26278529
    http://www.ncbi.nlm.nih.gov/pubmed/26150153
    http://www.ncbi.nlm.nih.gov/pubmed/24077511
    http://www.ncbi.nlm.nih.gov/pubmed/8899846
    http://www.ncbi.nlm.nih.gov/pubmed/8956339

    Caffeine:
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129466/
    http://www.ncbi.nlm.nih.gov/pubmed/25591953
    http://www.ncbi.nlm.nih.gov/pubmed/21505179
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353410/
    http://www.ncbi.nlm.nih.gov/pubmed/18179623
    http://www.ncbi.nlm.nih.gov/pubmed/17388926
    http://www.ncbi.nlm.nih.gov/pubmed/12570332
    http://www.ncbi.nlm.nih.gov/pubmed/12392153
     
  2. hmac

    hmac Member

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    Thanks for this Haidut!

    Presumably this would be one to use directly on a mole rather than the 'tease the mole' technique with DHEA that Peat has spoken about?

    A friend has psoriasis - might it be useful in combination with estroban?
     
  3. OP
    haidut

    haidut Member

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    Yes, this is intended for use directly on the mole as described in the individual studies. Since both naringenin and apigenin were found to be inhibitors of estrogen, nitric oxide (NO), 5-lipoxygenase (LOX) and COX and so on this supplement should synergize greatly with both EstroBan and SolBan.
    Just my 2c.
     
  4. Dan Wich

    Dan Wich Member

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    Glad this is out, Haidut, I'll try some and report back.

    Along the lines of hmac's question, do you think it'd be beneficial to also surround the mole with Pansterone (or any other DHEA)?
     
  5. OP
    haidut

    haidut Member

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    Probably yes, but I think mixing it with EstroBan and rubbing it directly on the mole may be more effective. Vitamin A and K are really good at controlling mole growth when applied directly. The Pansterone I would actually use orally as it has systemic effects as well. I had a mole fall off from 5mg oral DHEA taken for a week, while topically it was not very effective.
     
  6. GAF

    GAF Member

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    Ordered.

    It is so fun and exciting to experiment with all the great ideas on this forum. Is there a Mad Scientist smilie?
     
  7. OP
    haidut

    haidut Member

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    I guess the closest would be the "uber geek" even though it does not quite convey the same idea.
     
  8. NathanK

    NathanK Member

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    Ha, I've been on the fence about naringenin for a while and wasn't 100% if Ray thought it was estrogenic or not (I was thinking that Ray said it was one of the compounds in grapefruit that he didn't like). Bulk supplements on Amazon sells them in caps. I remember reading that body builders took it to increase caffeine absorption. Ironically you say it's the other way around! I didn't know it was good for skin health either. Thanks again. I look forward to reading the studies.

    Could this be good for small subcutaneous cysts?
     
  9. OP
    haidut

    haidut Member

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    Caffeine absorption is basically 100% no matter if you do oral or topical. Not sure if even DMSO can improve that absorption...
    It's naringenin that can use some enhancement, especially in a topical form.
     
  10. NathanK

    NathanK Member

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    Whoops, looks like I edited my comment too slow. Could this be good for small subcutaneous cysts you think?
     
  11. Nicholas

    Nicholas Member

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    thank you, Haidut. do you think this product would have any benefit to broken capillaries or spider vein type issues? I've heard talk of the flavanoids having some benefit to these skin-related aging signs primarily via Linus Pauling. I'm interested in ordering for the already stated uses, too.
     
  12. solaire_of_astora

    solaire_of_astora Member

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    Would this product work for skin tags as well?
     
  13. Peata

    Peata Member

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    I've started using this product today. I'm taking before and after pictures and I'm using it on a variety of places. One is a scar where I scraped the skin off my knee when I fell on ice last winter. Another is a surgery scar. Also a red spot.

    Finally, I want to try it all over my face to see if it helps with any discoloration or has a brightening effect. I used one drop and patted it all over.

    Haidut, do you think it's fine to use it over such a large area and 2) is once or twice per day best?
     
  14. OP
    haidut

    haidut Member

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    Caffeine has been shown to work on cysts, so maybe.
     
  15. OP
    haidut

    haidut Member

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    All of the compounds in the product are anti-angiogenic, so quite possible. Spider veins are usually from too much estrogen so a systemic anti-estrogen like oral vitamin E or aspirin would probably be better. But the topical application probably won't hurt either.
     
  16. OP
    haidut

    haidut Member

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    Not that I am aware of, but it is possible. Skin tags, just like spider veins, are sing of high estrogen. So, lowering estrogen systemically with oral vitamin E, aspirin, progesterone, caffeine, etc may be better for that purpose.
     
  17. OP
    haidut

    haidut Member

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    I think it is fine to use over large area but you may need higher dose. The studies showed that applying a human equivalent dose of 2mg to an area of 1/4 square inch was effective for moles. I don't know how much would be necessary for larger areas but it could be more than 2mg spread all over it.
     
  18. Nicholas

    Nicholas Member

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    cool, there are many pathways for estrogen to be elevated...if that's, as you say, even the cause. for example, i have found that they are diminishing by taking vitamin C recently.
     
  19. OP
    haidut

    haidut Member

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    Spider veins in particular are most likely caused by estrone (E1) and are related to poor liver function and detoxification of estrone. One example that there is no such thing as benign estrogen and the attempt to steer estrogen towards "benign" metabolites by taking things like I3C is at best misguided.
     
  20. Nicholas

    Nicholas Member

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    ok....i don't know what 13C is...
    the point i was making is that, if estrogen detoxification is the cause, there are many pathways by which one can heal the problem. the answer to lowering estrogen is not always Vitamin E/Aspirin/caffeine/etc or you have a blanket liver issue. i could post a number of studies here showing how vitamin C interacts with the liver, but i also don't think vitamin C is the answer for everyone. In my case, it makes sense though....because i'm a smoker, and have therefore possibly been vitamin C deficient. for some reason it is diminishing the capillary issue. will use your product as well and let you know.
     
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