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MCT Oil Reduces Seizures In Adults With Refractory Epilepsy

Discussion in 'Scientific Studies' started by agnostic, Feb 12, 2019.

  1. agnostic

    agnostic Member

    Joined:
    Dec 15, 2012
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    This is a highly interesting study that tested the effect of MCT oil (55% octanoate, 45% decanoate) vs triheptanoin (a triglyceride that is composed of three seven-carbon (C7:0) fatty acids) in adults with refractory epilepsy. MCT seemed to be more effective, although the difference was not significance. From the 9 people in the MCT group finishing the trial, 4 (45%) showed >50% seizure reduction and the overall seizure reduction in this group was 54%. In my opinion, these are highly impressive numbers considering that these were refractory patients.


    It seems that the research community is finally expanding its myopic and simplistic understanding of epilepsy as excitation/inhibition imbalance or "channelopathy". An increasing number researchers finally acknowledge that epilepsy is characterized by impaired energy metabolism and that restoration of impaired energy production is a much better treatment target. Here are some excellent review papers:
    Metabolism and epilepsy: Ketogenic diets as a homeostatic link. - PubMed - NCBI
    A Metabolic Paradigm for Epilepsy
    Impairments in Oxidative Glucose Metabolism in Epilepsy and Metabolic Treatments Thereof
     
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