Maternal Inflammation Causes Brain Damage (autism) By Raising Serotonin

Discussion in 'Scientific Studies' started by haidut, Jun 1, 2016.

  1. haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,446
    Gender:
    Male
    Location:
    USA / Europe
    I posted several studies recently about maternal hypothyroidism and stress being linked to autism, as well as the use of serotonin antagonist to reverse autism pathology in an animal model. This study adds more weight to the serotonin-autism connection. It showed that triggering flu-like symptoms and the release of endotoxin in the pregnant mother raised serotonin several-fold and caused brain damage and behavioral abnormality in offspring reminiscent of autism.

    Neuropsychopharmacology - Placental Source for 5-HT that Tunes Fetal Brain Development
    http://www.ncbi.nlm.nih.gov/pubmed/22001683
    Maternal inflammation boosts serotonin and impairs fetal brain development in mice
    http://medicalxpress.com/news/2016-05-maternal-inflammation-boosts-serotonin-impairs.html

    "...To answer these questions, they injected pregnant mice with either an immune-stimulating compound or a placebo 12 days into the pregnancy. The compound produces a mild inflammatory response in mice as well as causes brain and behavioral deficits in their offspring. After either 24 or 48 hours, the team analyzed the maternal blood, placenta, and fetal brains. In addition to having more inflammatory molecules in their blood streams, the treated mice had more than double the amount of tryptophan in their placentas 24 hours after the injection. After 48 hours, tryptophan levels had returned to normal, but the enzyme converting tryptophan into serotonin, tryptophan hydroxylase, was more active in treated mice. A separate experiment demonstrated that treated placenta produced four times as much serotonin. Finally, while the researchers found the offspring of treated mice had higher levels of serotonin in their brains, they also had fewer serotonin-containing nerve cells. The results suggest maternal inflammation increases the amount of serotonin in the placenta and the fetal brain, impairing the growth of serotonin nerve cells, the researchers say. The results "represent a paradigm shift for the effect of inflammation on the fetal brain development," said Irina Burd, an associate professor of gynecology and obstetrics at Johns Hopkins University who studies fetal brain development and was not involved in the study. "It may be possible that there are several ways that maternal inflammation may impact the fetal brain, and one of the mechanisms is through aberrant neurotransmitter levels.""
     
  2. jaguar43

    jaguar43 Member

    Joined:
    Oct 10, 2012
    Messages:
    1,306
    I keep wondering if vaccines have anything to do with autism. It's usual that vaccines are given during the same time that babies show signs of autism, so it would be logical to blame it on that, but with this study it shows that it's much more complex.
     
  3. Kasper

    Kasper Member

    Joined:
    Sep 11, 2013
    Messages:
    671
    Gender:
    Male
    What is meant with this sentence? Wouldn't that be beneficial, having less serotonin nerve cells?
     
  4. postman

    postman Member

    Joined:
    Mar 3, 2016
    Messages:
    695
    It could have multiple different causes.
     
  5. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,446
    Gender:
    Male
    Location:
    USA / Europe
    Well, I think the evidence points to the issue of any significantly stressful event during pregnancy or early childhood. Thyroid status of both mother and child would determine how much impact that stressful event would have. But inflammation, sickness, vaccines, family trouble, etc can all qualify as such events. When Peat was asked about vaccines he said they are "stressful" for the organism. So, they are simply a specific example of something that can cause autism if thyroid function is suboptimal.
     
  6. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,446
    Gender:
    Male
    Location:
    USA / Europe
    I think they meant "receptors". In general a high amount of serotonin or a serotonin agonist would decrease the number of serotonin "receptors" in the cell. It is an adaptation to high serotonin levels but the main issue is the high serotonin which affects the organism systemically. It will lower metabolism, cause fibrosis, hypogonadism, etc in addition to the brain damage. The receptors are irrelevant.
     
  7. grabster

    grabster Member

    Joined:
    Sep 7, 2015
    Messages:
    10
    Hey haidut, what do you think about this theory: acetominophen raising serotonin, which increases chance of autism.

    It explains alot
    1) the vaccine link, since vaccines cause a fever that is often treated with acetominiphen.
    2) why circumcised boys have a much greater chance of autism, since days of acetominophen are recommended after circumcision.
    3) The correlation between acetominophen use and autism diagnosis.
    4) low incidence of autism in cuba, where acetominophen is under embargo

    Lots of studies here, along with a theory about acetominophen affecting glutathione, but I think the serotonin link is stronger:
    www.autismstudies.net

    Also, two engineers are more likely to have an autistic child. Engineers (yours truly) are like robots running around all hopped up on serotonin, which I would guess affects the serotonin status of the child.
     
  8. dfspcc20

    dfspcc20 Member

    Joined:
    Dec 9, 2015
    Messages:
    410
    I've seen links to that as well:

    TYLENOL AND AUTISM
    Babies and children often get Tylenol (acetaminophen) after receiving a vaccination, and today many pediatricians are recommending a dose of Tylenol just before the vaccine, and even on a daily basis up to five days before the vaccine, in order to counteract the frequent post-vaccination high fever reaction. In an October 2013 webinar (www.greatplainslaboratory. com/home/eng/Acetaminophen.asp) endocrine expert William Shaw, PhD, makes the case that it is this allegedly “safe” over-the-counter painkiller that triggers autism in susceptible children, not the vaccination itself. Acetaminophen depletes glutathione, the body’s key cellular enzyme for antioxidant activity. Especially in children, a drop in glutathione may cause buildup of toxins and trigger brain changes. Dr. Shaw points out that in Cuba, the vaccination rate against measles is 99.7 percent, but the rate of autism there is about three hundred times lower than in the U.S. The reason may be that acetaminophen is not given to children after vaccinations in Cuba; in fact, acetaminophen is not approved for over-the-counter use in Cuba.

    From: Caustic Commentary, Winter 2013 - Weston A Price
     
  9. jaguar43

    jaguar43 Member

    Joined:
    Oct 10, 2012
    Messages:
    1,306
    That is interesting regarding the vaccination rate in Cuba and the autism rate. I think Tylenol can increase serotonin in the brain. That makes more sense than the vaccine theory in my opinion. Tylenol is extremely overrate and possibly dangerous.
     
  10. grabster

    grabster Member

    Joined:
    Sep 7, 2015
    Messages:
    10
  11. Makrosky

    Makrosky Member

    Joined:
    Oct 5, 2014
    Messages:
    2,385
    Gender:
    Male
    WTF????????
     
  12. jaguar43

    jaguar43 Member

    Joined:
    Oct 10, 2012
    Messages:
    1,306
  13. angelina

    angelina Member

    Joined:
    Dec 27, 2015
    Messages:
    8
    I didn't know that about Cuba...interesting. I have two kids with regressive autism and think there are multiple causes. It seems vaccines are reported as the cause by so many parents. We never saw that, but that is only our story. Met plenty of people that have seen it take their kid down. I've researched vaccines ad nauseum and feel they are not what they seem.
    I wish Dr. Peat would comment on Autism more.
     
  14. DaveFoster

    DaveFoster Member

    Joined:
    Jul 23, 2015
    Messages:
    4,846
    Gender:
    Male
    Occupation:
    Professional blogger, writer and entrepreneur.
    Location:
    Spokane, Washington
    Interesting.
     
  15. StrongMom

    StrongMom Member

    Joined:
    Apr 17, 2015
    Messages:
    232
    i have twin boys on autistic spectrum; one with more significant symptoms relative to the other. I understand that maternal environment causes autism but there should be a genetic element to it, too. Some people can be more prone to it. Someone on this forum (Davefoster maybe ???) was saying that autism is a way of adaptation to the stressful maternal environment (or in those lines). My son with more severe symptoms I think adapted to the environment but my other son didn't want to; he broke his water 8 weeks early and hence I went into labor.
     
  16. lexis

    lexis Member

    Joined:
    Jan 25, 2014
    Messages:
    413
    Chinese scalp acupuncture may help to treat autism
     
  17. Constatine

    Constatine Member

    Joined:
    Sep 28, 2016
    Messages:
    1,623
    Gender:
    Male
    Do you suppose overly logical people have high serotonin levels? I've not suspected that engineers would have more serotonin but it does make some sense.
     
  18. grabster

    grabster Member

    Joined:
    Sep 7, 2015
    Messages:
    10
    Im thinking that there is a pshysiological underpinning to the engineer's typical anti socialness and interest in predicting things with equations. Maybe serotonin, maybe something else. If engineers do have high serotonin, and since high serotonin parents have a higher chance of having an autistic kid, then it makes sense that engineers are more likely to have autistic kids. Maybe too simple....
     
  19. Regina

    Regina Member

    Joined:
    Aug 17, 2016
    Messages:
    1,811
    Gender:
    Female
    Location:
    Chicago
    The adjective that often comes to mind when meeting engineers is "prickly."
     
Loading...