Massive Pregnenolone Increase From THC!

[Pufa]

"Pier Vincenzo Piazza and Giovanni Marsicano noticed something peculiar: when lab mice were exposed to tetrahydrocannabinol (THC), the main active component in cannabis, their brains initiated a temporary 3,000 percent increase in the production of pregnenolone"

That's an enormous increase.. wonder if some of the benefits of marijuana come from the preg dump

 

[docall18]

I notice if i take a good dose of pregnenolone, I get little to no effect from strong weed.

The preg seems like the antidote to weed.

 

[ddjd]

is there a synthetic THC product we can get hold of or is it generally just the old fashioned option available?

 

[Pufa]

I notice if i take a good dose of pregnenolone, I get little to no effect from strong weed.

The preg seems like the antidote to weed.

ray mentioned it can help with quitting weed. Trying to figure a safe dosage for a man

 

[Grapelander]

Pregnenolone Can Protect the Brain from Cannabis Intoxication "Cannabis sativa (marijuana), ∆9-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation..."

 

[Greg says]

Haidut just did an interview with Matt Blackburn about cannabis saying this raise in pregnenolone was a defensive reaction to protect the brain.

 

[Atman]

Haidut just did an interview with Matt Blackburn about cannabis saying this raise in pregnenolone was a defensive reaction to protect the brain.

Interesting, but expected hypothesis from a Peat perspective.
Would be interesting to know, whether chronic cannabis users have depleted cholesterol/pregnenolone to validate this theory.
The disturbed memory of potheads would perfectly fit into that picture though.

 

[Frankdee20]

I notice if i take a good dose of pregnenolone, I get little to no effect from strong weed.

The preg seems like the antidote to weed.

Yes, it actually antagonizes the RECEPTORS.

 

[lilsticky]

Does anyone know why eating a mango can get you more stoned? I tried this a long time ago

 

[methylenewhite]

B-myrcene if remember it correctly