Mary Jane's Effect On Glucose, Insulin, And Insulin Resistance Among US Adults

zztr

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Is there some known great variation in ability to metabolize the actives in weed? I've partaken maybe ten times over the years and each time I felt distinctly off kilter for as long as three days. I can only assume regular users are in denial about the fact that they're nearly always a bit under the influence.
 

Fractality

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During my initial years of use, it typically unlocked a psychedelic dopaminergic state; increased creativity, appreciation for music and food. Of course, I would sometimes feel paranoid/anxious in certain situations and on the come down. This is why I would typically consume it by mself, with a few close friends, or with alcohol. Now, it tends make my mind feel fogged and it doesn't have the same powerful effects on creativity and my senses. Vaporizing tends towards a cleaner high.
 

Gl;itch.e

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Is it "Mary Jane" that's estrogenic or is it the PAHs when smoked
I think Peat said its mostly the smoke but that other parts may be as well. I understand it can raise progesterone. Too much of that is obviously going to be a bad thing for dudes.
 
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Epidemiological...

We gotta dig deeper.

1. How do we know if them having lowered fasting insulin is a good thing? I suspect having low fasting insulin is a good thing (or at least a sign of health), but I'm not confident enough to make that assumption in a case like this.

2. Let's say that it is a good thing. Does that mean smoking weed will give us the same benefit? Maybe those with pre-existing low fasting insulin are more likely to smoke cannabis, for whatever reason. Who knows if we'll experience the same. And who knows if it'll be good for us if we do.

Just trying to poke some holes...

Anecdotally, I have never met a smoker who benefited from smoking IRL. Online I've met a few, but they usually had conditions like autism or BPD.

For neurotypical people, it seems to universally make them worse.

Case in point: myself.

But I see ways in which it might be helpful, as a safe/effective band-aid.

It is extremely effective in treating insomnia though.
 
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walker_in_aus

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As a non user until my mid twenties, I found some surprising side effects when i decided to give it a go - my digestion improved, gut was calm and non inflamed despite some dubious food choices when i was high. I am currently in the grips of terrible insomnia and I've found just a tiny bit gets me to sleep and i sleep all night, albeit I have been pretty sleepy at work (I think studies done showed it reduced REM time) I've just taken leave from work to try and recover, and because marijuana is still illegal in my country and having a smoke every night is just not how I want to live my life. I have still found it to be AMAZING in comparison to all the freakin' diazepams doctors keep throwing at me.

Honestly if I have had insomnia for nearly two years I would have thought they would start referring me to sleep specialists instead of more and more drugs (melatonin, diazepam, nitrazepam, oxazepam, agomelatine, propranonol).

Didn't mean for this to turn into a rant, but MJ sure makes falling asleep just like a dream so easy.
 
OP
Elchapchapchapo
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I think what would be interesting is to see if the CBD - the property which does not cause psychoactive effects can produce these results on its own. If i recall right cbd has a wide profile on its own.
 

walker_in_aus

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I think what would be interesting is to see if the CBD - the property which does not cause psychoactive effects can produce these results on its own. If i recall right cbd has a wide profile on its own.

I think I read somewhere once that the human gut has a lot of cannabinoid receptors or something. I think the high CBD strains are the ones bringing in the money in the medicinal mj world.
 

Let Go

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When cannabis is ingested the liver produces 11-Hydroxy-THC which has different effects than THC and CBD. Not to mention cannabis is a schedule 1 so there's not a a lot of good research into what the health effects are.
There are definitely anti inflammatory and analgesic properties.
 
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http://www.ukcia.org/research/EndocrineEffects.pdf

Good paper.

"Animal studies have demonstrated an acute reduction of prolactin levels after THC administration in both rodents52 and primates.53 Smith et al53 showed that prolactin was reduced by a maximum of 84% in ovariectomized female monkeys and 74% in males at 30 to 90 minutes by a single injection of THC."

"Cannabinoids have been shown to inhibit GH secretion due to stimulation of somatostatin release."

"Acute administration of THC in rodents70,71 reduces levels of thyroxine and TSH by as much as 90% for up to 6 hours."
 

Samya

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I'm not sure if this may be related but I do feel as if the brains glucose requirement may increase with cannabis usage; the studies I've seen show that it can go either way - increase or decrease. A lot of people experience sugar cravings or 'the munchies' under the influence and I find sugar definitely abates the effects of the cannabis high, at least for a short period. I also noticed that initially with a ketogenic diet the strength of the effects seemed to increase to the point of discomfort (until eating something), yet after a longer adaptation the effects would be very short-lived.
 
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