Marijuana smoke is estrogenic

[ReSTART]

Estrogenic effects of marijuana smoke condensate and cannabinoid compounds - PubMed

Chronic exposure to marijuana produces adverse effects on the endocrine and reproductive systems in humans; however, the experimental evidence for this presented thus far has not been without controversy. In this study, the estrogenic effect of marijuana smoke condensate (MSC) was evaluated...

pubmed.ncbi.nlm.nih.gov

Chronic exposure to marijuana produces adverse effects on the endocrine and reproductive systems in humans; however, the experimental evidence for this presented thus far has not been without controversy. In this study, the estrogenic effect of marijuana smoke condensate (MSC) was evaluated using in vitro bioassays, viz., the cell proliferation assay, the reporter gene assay, and the ER competitive binding assay. The results of these assays were compared with those of three major cannabinoids, i.e., THC, CBD, and CBN. The estrogenic effect of MSC was further confirmed by the immature female rat uterotrophic assay. MSC stimulated the estrogenicity related to the ER-mediated pathway, while neither THC, CBD, nor CBN did. Moreover, treatment with 10 and 25 mg/kg MSC induced significant uterine response, and 10 mg/kg MSC resulted in an obvious change in the uterine epithelial cell appearance. MSC also enhanced the IGFBP-1 gene expression in a dose-dependent manner. To identify the constituents of MSC responsible for its estrogenicity, the MSC fractionated samples were examined using another cell proliferation assay, and the estrogenic active fraction was analyzed using GC-MS. In the organic acid fraction that showed the strongest estrogenic activity among the seven fractions of MSC, phenols were identified. Our results suggest that marijuana abuse is considered an endocrine-disrupting factor. Furthermore, these results suggest that the phenolic compounds contained in MSC play a role in its estrogenic effect.

 

[Quelsatron]

Isn't smoke estrogenic in general? Something to do with the polycyclic aromatic hydrocarbons or whatever, or maybe that's just in soot

 

[ReSTART]

Isn't smoke estrogenic in general? Something to do with the polycyclic aromatic hydrocarbons or whatever, or maybe that's just in soot

Yes all smoke is estrogenic, which is probably why they don’t notice the same effect with pure THC or CBD.

 

[equipoise]

I'd rather smoke a joint then drink alcohol, mixing joints with Tobacco gets rid of the estrogenic effects anyways.
Popping an aspirin 500 before aswell and everything is golden. No hangover in the morning, and socially it's amazing IMHO.
It's not to be abused every day, obviously, but every now and then for me in place of alcohol is much better.