Manganese Mimics Insulin

[paymanz]

-manganese increases co2 production from glucose

-inhibits lipolysis

-increases lipogenesis

Regulation of glucose utilization and lipogenesis in adipose tissue of diabetic and fat fed animals: effects of insulin and manganese. - PubMed - NCBI

 

[paymanz]

The effect of manganese on lipogenesis, lipolysis, adenosine 3',5' cyclic monophosphate and cyclic nucleotide phosphodiesterase activity in adipocy... - PubMed - NCBI

Summary The insulin-like action of Mn 2 + was investigated in adipo- cytes isolated from male mice of the NZY strain. In agree- ment with previous reports Mn 2 + was found to stimulate both the oxidation of [U- 14 C]glucose to CO2 and the incor- poration of [U- 14 C]glucose into total lipid and fatty acid, and to inhibit lipolysis stimulated by epinephrine, cyclic AMP or theophylline. The maximum effect of Mn 2+ was greater than that of a maximal concentration of insulin and when both agents were present in these concentrations the effect was similar to that observed with Mn 2 + alone. Mn 2 + lowered the level of cyclic AMP in adipocytes incubat- ed with isoproterenol. The effect was seen as early as 1 min- ute and it was greater than a maximal concentration of insu- lin. When Mn 2 + was added to suspensions of adipocytes it increased the activity of the membrane-bound low Km cyclic nucleotide phosphodiesterase in subsequently prepared homo- genates. The enzyme was stimulated 1.8-fold by Mn 2 + com- pared with a 1.7-fold stimulation by insulin and a 2-fold sti- mulation in the presence of both Mn 2 + and insulin.

 

[Makrosky]

It's time to hit the maple syrup? Sugar+Manganese....

 

[tyler]

great... just what i needed- further justification to swig the maple syrup jug every time i open the fridge.

 

[shine]

Wouldn't that lead to more fat gain?

 

[GorillaHead]

Ya i dont want fat

 

[Michael Mohn]

Pineapple has good amounts of manganese and other goodies.

 

[Coderr]

Which foods are rich in manganese?

 

[not_James_Bond]

Pineapple has good amounts of manganese and other goodies.

Yeah, Pineapple is one fruit I never tire of, even canned Pineapple, add Coconut water, heaven

 

[Recoen]

The effect of manganese on lipogenesis, lipolysis, adenosine 3',5' cyclic monophosphate and cyclic nucleotide phosphodiesterase activity in adipocy... - PubMed - NCBI

Summary The insulin-like action of Mn 2 + was investigated in adipo- cytes isolated from male mice of the NZY strain. In agree- ment with previous reports Mn 2 + was found to stimulate both the oxidation of [U- 14 C]glucose to CO2 and the incor- poration of [U- 14 C]glucose into total lipid and fatty acid, and to inhibit lipolysis stimulated by epinephrine, cyclic AMP or theophylline. The maximum effect of Mn 2+ was greater than that of a maximal concentration of insulin and when both agents were present in these concentrations the effect was similar to that observed with Mn 2 + alone. Mn 2 + lowered the level of cyclic AMP in adipocytes incubat- ed with isoproterenol. The effect was seen as early as 1 min- ute and it was greater than a maximal concentration of insu- lin. When Mn 2 + was added to suspensions of adipocytes it increased the activity of the membrane-bound low Km cyclic nucleotide phosphodiesterase in subsequently prepared homo- genates. The enzyme was stimulated 1.8-fold by Mn 2 + com- pared with a 1.7-fold stimulation by insulin and a 2-fold sti- mulation in the presence of both Mn 2 + and insulin.



View attachment 3767 View attachment 3768

Pyruvate carboxylase. Biotin is needed too.