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Manganese Mimics Insulin

Discussion in 'Articles & Scientific Studies' started by paymanz, Oct 28, 2016.

  1. paymanz

    paymanz Member

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  2. OP
    paymanz

    paymanz Member

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    The effect of manganese on lipogenesis, lipolysis, adenosine 3',5' cyclic monophosphate and cyclic nucleotide phosphodiesterase activity in adipocy... - PubMed - NCBI

    Summary The insulin-like action of Mn 2 + was investigated in adipo- cytes isolated from male mice of the NZY strain. In agree- ment with previous reports Mn 2 + was found to stimulate both the oxidation of [U- 14 C]glucose to CO2 and the incor- poration of [U- 14 C]glucose into total lipid and fatty acid, and to inhibit lipolysis stimulated by epinephrine, cyclic AMP or theophylline. The maximum effect of Mn 2+ was greater than that of a maximal concentration of insulin and when both agents were present in these concentrations the effect was similar to that observed with Mn 2 + alone. Mn 2 + lowered the level of cyclic AMP in adipocytes incubat- ed with isoproterenol. The effect was seen as early as 1 min- ute and it was greater than a maximal concentration of insu- lin. When Mn 2 + was added to suspensions of adipocytes it increased the activity of the membrane-bound low Km cyclic nucleotide phosphodiesterase in subsequently prepared homo- genates. The enzyme was stimulated 1.8-fold by Mn 2 + com- pared with a 1.7-fold stimulation by insulin and a 2-fold sti- mulation in the presence of both Mn 2 + and insulin.



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  3. Makrosky

    Makrosky Member

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    It's time to hit the maple syrup? Sugar+Manganese....
     
  4. tyler

    tyler Member

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    great... just what i needed- further justification to swig the maple syrup jug every time i open the fridge.
     
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