Sex Differences in the Survival of Copper-Deficient Rats
Abstract. Male rats fed fructose-based, low-copper diets show 100 percent mortality, cardiac hypertrophy, and anemia under conditions where female rats fed
academic.oup.com
My thoughts: It is well-known that estrogen facilitates the absorption of copper, and it appears to be true that high fructose consumption places an increased demand on the body's copper stores. This may be worth bearing in mind particularly for men on a high-fructose diet, as well as for the women on here using supplements as aromatase inhibitors etc. and trying to aggressively lower their estrogen levels. Ray has written on the importance of copper; it's key as a structural component in the body (collagen and bone) and for many enzymes including those that break down histamine.