Maintenance Of Red Blood Cell Integrity By AMP-activated Protein Kinase α1 Catalytic Subunit


Jan 6, 2015


AMP-activated protein kinase (AMPK) plays a pivotal role in regulating cellular energy metabolism. We previously showed that AMPKα1−/− mice develop moderate anemia associated with splenomegaly and high reticulocytosis. Here, we report that splenectomy of AMPKα1−/− mice worsened anemia supporting evidence that AMPKα1−/− mice developed a compensatory response through extramedullary erythropoiesis in the spleen. Transplantation of bone marrow from AMPKα1−/− mice into wild-type recipients recapitulated the hematologic phenotype. Further, AMPKα1−/− red blood cells (RBC) showed less deformability in response to shear stress limiting their membrane flexibility. Thus, our results highlight the crucial role of AMPK to preserve RBC integrity.


Thread starter
Jan 6, 2015
But what does it mean :-o
that means things that increase ampk can increase flexibility of RBCs and improve circulation!

substances like Pentoxifylline and probably caffeine and some other peaty things.
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