Maintenance Of Red Blood Cell Integrity By AMP-activated Protein Kinase α1 Catalytic Subunit

paymanz

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http://www.sciencedirect.com/science/article/pii/S0014579310005995

Abstract

AMP-activated protein kinase (AMPK) plays a pivotal role in regulating cellular energy metabolism. We previously showed that AMPKα1−/− mice develop moderate anemia associated with splenomegaly and high reticulocytosis. Here, we report that splenectomy of AMPKα1−/− mice worsened anemia supporting evidence that AMPKα1−/− mice developed a compensatory response through extramedullary erythropoiesis in the spleen. Transplantation of bone marrow from AMPKα1−/− mice into wild-type recipients recapitulated the hematologic phenotype. Further, AMPKα1−/− red blood cells (RBC) showed less deformability in response to shear stress limiting their membrane flexibility. Thus, our results highlight the crucial role of AMPK to preserve RBC integrity.
 

paymanz

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But what does it mean :-o
that means things that increase ampk can increase flexibility of RBCs and improve circulation!

substances like Pentoxifylline and probably caffeine and some other peaty things.
 
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