Magnesium Sulphate Prevents LPS (endotoxin) Induced Cell Death

raypeatclips

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Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta. - PubMed - NCBI

Pregnancy Hypertens. 2016 Oct;6(4):356-360. doi: 10.1016/j.preghy.2016.08.237. Epub 2016 Aug 30.
Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta.
Williamson RD1, McCarthy C1, Kenny LC2, O'Keeffe GW3.


"MgSO4 had a dose dependent effect of cell viability with a narrow therapeutic window. MgSO4 (1mM) protected against adverse effects of LPS on cell viability by preventing LPS-induced decreases in cell viability (MTT assay) and protecting against LPS-induced pyknotic changes in nuclear membrane. MgSO4 also inhibited the elevated TNF-α mRNA expression induced by LPS."
 

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