Magnesium Chloride Oral Use

[Dave Clark]

Have you a personal favorite form, if not MgCl2? Seems I need to take more MgCl2 than I already do to keep regular, which is why I used to use Mg citrate almost exclusively. Maybe a question for another thread, but what about a combo formula of glycinate, lysinate, carbonate, and citrate?

Check out Dr. Carolyn Dean's picometer ionic magnesium chloride product called ReMag. Best of the bunch!

 

[Kray]

How does ReMag differ from any other MgCl2 in its efficacy or absorption? The brand I use dissolves completely when added to water. Wouldn’t that be a good indicator of cellular absorption?

 

[Kray]

@Dave Clark: Since ReMag is apparently so highly concentrated in Mg, would it help someone who suffers from constipation, without the need to take as much as other brands?

 

[Amazoniac]

35% magnesium and 75% chloride

: idi
25% to 75% is quite a difference..

 

[Amazoniac]

Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update

"With a daily intake of 370 mg, the absorption rate of Mg2+ in the intestine ranges from 30-50% [13]. However, the efficiency of Mg2+ uptake is dependent on the ingested dose [15, 16]. For example, early studies with a low dietary Mg2+ intake showed that the relative absorption rate can reach 80% [17], whereas it is reduced to 20% with Mg2+ surfeits [18]."

"The kidney is the primary organ that regulates Mg2+ homeostasis [39]." "only approximately 5% of the filtered Mg2+ is excreted under normal conditions. Excessive Mg2+ is almost entirely excreted through the kidneys, which is also the case in hypermagnesaemia. Consequently, supplementation with Mg2+ usually increases renal Mg2+ excretion to varying degrees, depending on the quantity absorbed."

"The efficiency of the gastrointestinal tract in absorbing micronutrients is negatively affected by increasing age [44]. This trend also applies to Mg2+. Coudray et al. (2006) investigated the effect of ageing on mineral absorption in the intestine using a stable isotope approach in rats [45]. The authors showed that aged rats exhibited less efficient intestinal absorption of 25Mg2+. Young and adult rats absorbed 56%, whereas Mg2+ absorption decreased to 45% in old and very old rats."

"It is generally thought that the relative absorption of Mg2+ is inversely related to the ingested dose; in other words, the quantity of Mg2+ in the digestive tract is the major factor controlling the amount of Mg2+ absorbed. For example, in 1991, Fine et al. showed that in humans, the relative Mg2+ absorption rate from a daily dose of 36 mg was 65%, whereas, only 11% was absorbed from a daily dose of 973 mg, apparently due to the greater restriction of intestinal permeability to Mg2+ [47]. However, it should be noted that absolute absorption increased with each increment in intake [47]."

"several human studies observed higher bioavailabilities when a given amount of Mg2+ was distributed over the span of a day rather than being consumed in a single bolus [29, 47, 49, 50]. Ekmekcioglu et al. (2000) showed that the upper range of Mg2+ absorption was obtained for the lowest ingested amount of Mg2+ in a study with adults [31]."
@Such_Saturation

"The mean Mg2+ absorption from mineral water consumed alone was 45.7±4.6% but was significantly greater (p = 0.0001) when consumed with a meal (52.3±3.9%), which is a relative difference of 14.4%. Therefore, the Mg2+ bioavailability from mineral water is enhanced when the water is consumed with a meal, perhaps because of a slower gastrointestinal transit time or the presence of other food constituents (or both). A slower transit time may lead to an increased exposure of the mucosal cells of the intestine to Mg2+ and thus a higher total absorption. Surprisingly, Verhas et al. (2002) [46] observed a mean Mg2+ bioavailability rate of 59±13.6% from carbonated water consumed without a meal, which lies in the upper reported range for solid foods."

"In many western countries, bread is an important source of Mg2+. Lopez et al. (2004) compared the effects of different kinds of bread fermentation on Mg2+ bioavailability in rats [55]. The authors found that although yeast fermentation minimizes the unfavourable effects of phytic acid on Mg2+ bioavailability, sourdough bread is the better source of available Mg2+. Consumption of Maillard reaction products present in food (e.g., bread crust) has been related to deterioration of protein digestibility and changes in mineral bioavailability [56-58]. However, in a balance study with rats, no influence of Maillard reaction products from bread crust on Mg2+ balance was observed [59]."

"Various dietary factors that promote Mg2+ bioavailability have been investigated in animal and human studies. Several early human studies showed that higher protein intake increased Mg2+ absorption compared to lower intake [60-63], possibly by preventing the precipitation of calcium-Mg2+-phosphate complexes in the ileum resulting in an increased solubility of Mg2+ [64]. Likewise, lipids impact the absorbability of Mg2+, whereby the lipid composition is suggested to be the influencing factor. Rat studies showed that a replacement of Medium Chain Triglycerides (MCT) for Long Chain Triglycerides (LCT) increased Mg2+ absorption [65, 66], possibly due to more soluble Mg2+ soaps of saturated fatty acids compared to insoluble Mg2+ salts formed with unsaturated fatty acids [67]. Conversely, studies on the influence of absolute fat mass on Mg2+ absorption have not produced consistent results ([68-70], reviewed in [64])."

"The stimulatory effect of GOS-and possibly other low- or indigestible carbohydrates on mineral uptake might be attributed to the effects of short-chain fatty acids (lactate, acetate, propionate, butyrate) and reduced pH in the large intestine produced through fermentation of the carbohydrates by intestinal bacteria (mainly bifidobacteria) [75, 83]. The resulting lower caecal pH may increase solubility of minerals, thereby enhancing their absorption from the colon and caecum [84]. A rat study observed that the promoting effect of GOS on Mg2+ absorption was diminished by neomycin treatment (bacteria-suppressing), suggesting that the GOS-effect is dependent on the action of intestinal bacteria [75]."

"An enhancing effect of lactose on Mg2+ absorption has been demonstrated in two studies with lactase-deficient rats [86, 87], but human studies have shown mixed results. An early study by Ziegler and Fomon (1983) observed an enhanced Mg2+ absorption of lactose in healthy infants compared to sucrose and polyose [88], whereas other studies with preterm infants [89] or term infants [90] did not find significant differences. There have been no studies with human adults investigating the effect of lactose on Mg2+ absorption."

"Early studies reported that increasing calcium in the diet significantly depressed Mg2+ absorption [91, 92]. The same depressive effect on Mg2+ absorption was shown with excess phosphorus, iron, copper, manganese [93] and zinc [94]. However, in these studies, unphysiological doses of the minerals were used. When these substances are consumed within a physiological range, such as present in a regular diet, the inhibiting effects have not been observed [64]. For example, long-term Mg2+ balance studies with calcium doses >1.000 mg/d did not produce a negative effect on Mg2+ uptake [35, 94, 95]. Andon et al. (1996) demonstrated in a human study with 26 adolescent girls that high calcium intake (1.667 mg/d) had no relevant impact on measures of Mg2+ utilization, including the absorption rate or urinary or faecal excretion [95]. Likewise, a balance study with adolescent girls showed that high calcium intake (1.800 mg/d) did not alter Mg2+ kinetics or balance compared to a calcium intake of 800 mg/d [35]."

"Oxalic Acid (OA) is present in high amounts in members of the spinach family and in brassicas (cabbage, broccoli, brussels sprouts). The conjugate base of OA, oxalate, is a chelating agent for metal cations and thus affects the gastrointestinal bioavailability of Mg2+. The effect of OA on Mg2+ absorption has been studied in rats [96] and humans [32]. Kikunaga et al. (1995) investigated Mg2+ availability from OA-rich spinach in Mg2+-deficient rats [96]. The authors demonstrated that OA in spinach impairs Mg2+ absorption. In a cross-over study with healthy humans and stable isotopes 25Mg2+ and 26Mg2+, Bohn et al. (2004) evaluated Mg2+ absorption from a test meal served with an OA-rich vegetable, spinach (6.6 mmol OA), compared to a test meal with kale, a vegetable with low OA content (0.1 mmol) [32]. The authors demonstrated that Mg2+ absorption from the OA-rich spinach meal was significantly lower compared to the kale meal."

"In a bioavailability study, Bohn et al. (2004) demonstrated that PA [peatic acid] dose-dependently lowers Mg2+ absorption [33]."

"Two other human studies also observed a significant increase in faecal Mg2+ when cellulose was added to the diet [101, 102]. However, neither study matched the Mg2+ concentrations between the diet groups. Fibres such as hemicellulose and pectin are partly fermentable by intestinal bacteria. Two human studies with healthy males showed an inhibitory effect of hemicellulose on Mg2+ absorption [100, 103]. The effect of pectin on Mg2+ absorption remains controversial."

"Unlike starch derived from cereals or other plants, potato starch contains considerable amounts of phosphorus [105], which is esterified on the carbon-6-hydroxyl group of the glucose molecule [106]. Other esterified phosphorus-bonded compounds in food sources, e.g., casein phosphopeptide, are known to enhance the absorption of calcium and other minerals [107]. Therefore, Mineo et al. (2009) examined the effect of potato starch feeding for 1, 3, and 5 weeks on apparent Mg2+ absorption in bone using a balance study in rats [98]. Two kinds of potato starch (Benimaru potato starch and Konafubuki potato starch) containing different phosphorus contents were used as carbohydrate sources. However, instead of increasing the absorption rate, the ingestion of potato decreased the absorption of Mg2+. The inhibiting effect is likely due to the binding effect of esterified phosphorus on Mg2+ and, thus, to enhanced faecal excretion. The study results, which were obtained in growing male rats, are difficult to extrapolate directly to humans. To evaluate the effect of potato starch and esterified phosphorus on Mg2+ bioavailability in humans, further experiments are needed."

"In the past, attention has been given to the type of Mg2+ salt that should be administered, especially with respect to supplements. This aspect should be critically discussed in view of other factors influencing bioavailability and retention of the mineral. Surprisingly, there are only a few animal and human studies investigating the bioavailability of different Mg2+ salts (Table 44). In a rat study, Coudray et al. (2005) determined the intestinal Mg2+ absorption and urinary excretion of various organic and inorganic Mg2+ salts using stable isotopes (26Mg2+) [38]. Eighty male Mg2+-depleted Wistar rats were fed the same diet replete with Mg2+ (550 mg Mg2+/kg) as oxide, chloride, sulphate, carbonate, acetate, pidolate, citrate, gluconate, lactate or aspartate. The Mg2+ absorption values obtained varied from 50% to 67%. Organic Mg2+ salts were slightly more available than inorganic Mg2+ salts, whereas Mg2+ gluconate exhibited the highest Mg2+ bioavailability. However, the study demonstrated that all Mg2+ salts were equally efficient in restoring rats’ blood Mg2+ levels in plasma and red blood cells. Although humans and rats have some differences in intestinal physiology, these results may be extrapolated to human Mg2+ nutrition with necessary precautions."

"Firoz & Graber (2001) determined the Mg2+ bioavailability in four commercial Mg2+ preparations (Mg2+ oxide, Mg2+ chloride, Mg2+ lactate and Mg2+ aspartate) in human subjects by using urinary Mg2+ excretion [115]. They observed a relatively poor bioavailability of Mg2+ oxide but a greater or equivalent bioavailability of the other three Mg2+ salts. Dolinska & Ryszka (2004) studied the influence of three different salts at different concentrations on Mg2+ absorption in the small intestine of rats using the area under the curve as the endpoint for Mg2+ bioavailability [121]. Mg2+ absorption was shown to be most efficient from Mg2+ gluconate compared to Mg2+ fumarate or Mg2+ chloride forms."

[B]♛[/B]

 

[Kray]

Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update

"With a daily intake of 370 mg, the absorption rate of Mg2+ in the intestine ranges from 30-50% [13]. However, the efficiency of Mg2+ uptake is dependent on the ingested dose [15, 16]. For example, early studies with a low dietary Mg2+ intake showed that the relative absorption rate can reach 80% [17], whereas it is reduced to 20% with Mg2+ surfeits [18]."

"The kidney is the primary organ that regulates Mg2+ homeostasis [39]." "only approximately 5% of the filtered Mg2+ is excreted under normal conditions. Excessive Mg2+ is almost entirely excreted through the kidneys, which is also the case in hypermagnesaemia. Consequently, supplementation with Mg2+ usually increases renal Mg2+ excretion to varying degrees, depending on the quantity absorbed."

"The efficiency of the gastrointestinal tract in absorbing micronutrients is negatively affected by increasing age [44]. This trend also applies to Mg2+. Coudray et al. (2006) investigated the effect of ageing on mineral absorption in the intestine using a stable isotope approach in rats [45]. The authors showed that aged rats exhibited less efficient intestinal absorption of 25Mg2+. Young and adult rats absorbed 56%, whereas Mg2+ absorption decreased to 45% in old and very old rats."

"It is generally thought that the relative absorption of Mg2+ is inversely related to the ingested dose; in other words, the quantity of Mg2+ in the digestive tract is the major factor controlling the amount of Mg2+ absorbed. For example, in 1991, Fine et al. showed that in humans, the relative Mg2+ absorption rate from a daily dose of 36 mg was 65%, whereas, only 11% was absorbed from a daily dose of 973 mg, apparently due to the greater restriction of intestinal permeability to Mg2+ [47]. However, it should be noted that absolute absorption increased with each increment in intake [47]."

"several human studies observed higher bioavailabilities when a given amount of Mg2+ was distributed over the span of a day rather than being consumed in a single bolus [29, 47, 49, 50]. Ekmekcioglu et al. (2000) showed that the upper range of Mg2+ absorption was obtained for the lowest ingested amount of Mg2+ in a study with adults [31]."
@Such_Saturation

"The mean Mg2+ absorption from mineral water consumed alone was 45.7±4.6% but was significantly greater (p = 0.0001) when consumed with a meal (52.3±3.9%), which is a relative difference of 14.4%. Therefore, the Mg2+ bioavailability from mineral water is enhanced when the water is consumed with a meal, perhaps because of a slower gastrointestinal transit time or the presence of other food constituents (or both). A slower transit time may lead to an increased exposure of the mucosal cells of the intestine to Mg2+ and thus a higher total absorption. Surprisingly, Verhas et al. (2002) [46] observed a mean Mg2+ bioavailability rate of 59±13.6% from carbonated water consumed without a meal, which lies in the upper reported range for solid foods."

"In many western countries, bread is an important source of Mg2+. Lopez et al. (2004) compared the effects of different kinds of bread fermentation on Mg2+ bioavailability in rats [55]. The authors found that although yeast fermentation minimizes the unfavourable effects of phytic acid on Mg2+ bioavailability, sourdough bread is the better source of available Mg2+. Consumption of Maillard reaction products present in food (e.g., bread crust) has been related to deterioration of protein digestibility and changes in mineral bioavailability [56-58]. However, in a balance study with rats, no influence of Maillard reaction products from bread crust on Mg2+ balance was observed [59]."

"Various dietary factors that promote Mg2+ bioavailability have been investigated in animal and human studies. Several early human studies showed that higher protein intake increased Mg2+ absorption compared to lower intake [60-63], possibly by preventing the precipitation of calcium-Mg2+-phosphate complexes in the ileum resulting in an increased solubility of Mg2+ [64]. Likewise, lipids impact the absorbability of Mg2+, whereby the lipid composition is suggested to be the influencing factor. Rat studies showed that a replacement of Medium Chain Triglycerides (MCT) for Long Chain Triglycerides (LCT) increased Mg2+ absorption [65, 66], possibly due to more soluble Mg2+ soaps of saturated fatty acids compared to insoluble Mg2+ salts formed with unsaturated fatty acids [67]. Conversely, studies on the influence of absolute fat mass on Mg2+ absorption have not produced consistent results ([68-70], reviewed in [64])."

"The stimulatory effect of GOS-and possibly other low- or indigestible carbohydrates on mineral uptake might be attributed to the effects of short-chain fatty acids (lactate, acetate, propionate, butyrate) and reduced pH in the large intestine produced through fermentation of the carbohydrates by intestinal bacteria (mainly bifidobacteria) [75, 83]. The resulting lower caecal pH may increase solubility of minerals, thereby enhancing their absorption from the colon and caecum [84]. A rat study observed that the promoting effect of GOS on Mg2+ absorption was diminished by neomycin treatment (bacteria-suppressing), suggesting that the GOS-effect is dependent on the action of intestinal bacteria [75]."

"An enhancing effect of lactose on Mg2+ absorption has been demonstrated in two studies with lactase-deficient rats [86, 87], but human studies have shown mixed results. An early study by Ziegler and Fomon (1983) observed an enhanced Mg2+ absorption of lactose in healthy infants compared to sucrose and polyose [88], whereas other studies with preterm infants [89] or term infants [90] did not find significant differences. There have been no studies with human adults investigating the effect of lactose on Mg2+ absorption."

"Early studies reported that increasing calcium in the diet significantly depressed Mg2+ absorption [91, 92]. The same depressive effect on Mg2+ absorption was shown with excess phosphorus, iron, copper, manganese [93] and zinc [94]. However, in these studies, unphysiological doses of the minerals were used. When these substances are consumed within a physiological range, such as present in a regular diet, the inhibiting effects have not been observed [64]. For example, long-term Mg2+ balance studies with calcium doses >1.000 mg/d did not produce a negative effect on Mg2+ uptake [35, 94, 95]. Andon et al. (1996) demonstrated in a human study with 26 adolescent girls that high calcium intake (1.667 mg/d) had no relevant impact on measures of Mg2+ utilization, including the absorption rate or urinary or faecal excretion [95]. Likewise, a balance study with adolescent girls showed that high calcium intake (1.800 mg/d) did not alter Mg2+ kinetics or balance compared to a calcium intake of 800 mg/d [35]."

"Oxalic Acid (OA) is present in high amounts in members of the spinach family and in brassicas (cabbage, broccoli, brussels sprouts). The conjugate base of OA, oxalate, is a chelating agent for metal cations and thus affects the gastrointestinal bioavailability of Mg2+. The effect of OA on Mg2+ absorption has been studied in rats [96] and humans [32]. Kikunaga et al. (1995) investigated Mg2+ availability from OA-rich spinach in Mg2+-deficient rats [96]. The authors demonstrated that OA in spinach impairs Mg2+ absorption. In a cross-over study with healthy humans and stable isotopes 25Mg2+ and 26Mg2+, Bohn et al. (2004) evaluated Mg2+ absorption from a test meal served with an OA-rich vegetable, spinach (6.6 mmol OA), compared to a test meal with kale, a vegetable with low OA content (0.1 mmol) [32]. The authors demonstrated that Mg2+ absorption from the OA-rich spinach meal was significantly lower compared to the kale meal."

"In a bioavailability study, Bohn et al. (2004) demonstrated that PA [peatic acid] dose-dependently lowers Mg2+ absorption [33]."

"Two other human studies also observed a significant increase in faecal Mg2+ when cellulose was added to the diet [101, 102]. However, neither study matched the Mg2+ concentrations between the diet groups. Fibres such as hemicellulose and pectin are partly fermentable by intestinal bacteria. Two human studies with healthy males showed an inhibitory effect of hemicellulose on Mg2+ absorption [100, 103]. The effect of pectin on Mg2+ absorption remains controversial."

"Unlike starch derived from cereals or other plants, potato starch contains considerable amounts of phosphorus [105], which is esterified on the carbon-6-hydroxyl group of the glucose molecule [106]. Other esterified phosphorus-bonded compounds in food sources, e.g., casein phosphopeptide, are known to enhance the absorption of calcium and other minerals [107]. Therefore, Mineo et al. (2009) examined the effect of potato starch feeding for 1, 3, and 5 weeks on apparent Mg2+ absorption in bone using a balance study in rats [98]. Two kinds of potato starch (Benimaru potato starch and Konafubuki potato starch) containing different phosphorus contents were used as carbohydrate sources. However, instead of increasing the absorption rate, the ingestion of potato decreased the absorption of Mg2+. The inhibiting effect is likely due to the binding effect of esterified phosphorus on Mg2+ and, thus, to enhanced faecal excretion. The study results, which were obtained in growing male rats, are difficult to extrapolate directly to humans. To evaluate the effect of potato starch and esterified phosphorus on Mg2+ bioavailability in humans, further experiments are needed."

"In the past, attention has been given to the type of Mg2+ salt that should be administered, especially with respect to supplements. This aspect should be critically discussed in view of other factors influencing bioavailability and retention of the mineral. Surprisingly, there are only a few animal and human studies investigating the bioavailability of different Mg2+ salts (Table 44). In a rat study, Coudray et al. (2005) determined the intestinal Mg2+ absorption and urinary excretion of various organic and inorganic Mg2+ salts using stable isotopes (26Mg2+) [38]. Eighty male Mg2+-depleted Wistar rats were fed the same diet replete with Mg2+ (550 mg Mg2+/kg) as oxide, chloride, sulphate, carbonate, acetate, pidolate, citrate, gluconate, lactate or aspartate. The Mg2+ absorption values obtained varied from 50% to 67%. Organic Mg2+ salts were slightly more available than inorganic Mg2+ salts, whereas Mg2+ gluconate exhibited the highest Mg2+ bioavailability. However, the study demonstrated that all Mg2+ salts were equally efficient in restoring rats’ blood Mg2+ levels in plasma and red blood cells. Although humans and rats have some differences in intestinal physiology, these results may be extrapolated to human Mg2+ nutrition with necessary precautions."

"Firoz & Graber (2001) determined the Mg2+ bioavailability in four commercial Mg2+ preparations (Mg2+ oxide, Mg2+ chloride, Mg2+ lactate and Mg2+ aspartate) in human subjects by using urinary Mg2+ excretion [115]. They observed a relatively poor bioavailability of Mg2+ oxide but a greater or equivalent bioavailability of the other three Mg2+ salts. Dolinska & Ryszka (2004) studied the influence of three different salts at different concentrations on Mg2+ absorption in the small intestine of rats using the area under the curve as the endpoint for Mg2+ bioavailability [121]. Mg2+ absorption was shown to be most efficient from Mg2+ gluconate compared to Mg2+ fumarate or Mg2+ chloride forms."

[B]♛[/B]

Thanks for these study postings, very helpful.

Question: Is it a good thing to test one’s Mg needs by bowel tolerance? I find it confusing. Is it the quality (poor absorption) or quantity of Mg (too much) that is responsible for bowel intolerance?

 

[Amazoniac]

Thanks for these study postings, very helpful.

Question: Is it a good thing to test one’s Mg needs by bowel tolerance? I find it confusing. Is it the quality (poor absorption) or quantity of Mg (too much) that is responsible for bowel intolerance?

Concentrated minerals can change the balance of bowels too fast, perhaps this is perceived as something strange to be expelled as soon as possible. Travisord wrote a bit about it here, on the osmotic potential, "I think Koch..":
Cascara Sagrada Long-Term Safety
I believe you have to go by feel, bowel tolerance is not a good measure.

 

[Kray]

Concentrated minerals can change the balance of bowels too fast, perhaps this is perceived as something strange to be expelled as soon as possible. Travisord wrote a bit about it here, on the osmotic potential, "I think Koch..":
Cascara Sagrada Long-Term Safety
I believe you have to go by feel, bowel tolerance is not a good measure.

Thanks for the link, very helpful. Especially on CS discussion. Encouraging, since I use it regularly, too.

 

[Amazoniac]

Influence of the thyroid on exocrine pancreatic function
Impaired thyroid often appears along with impaired kidneys as well. Sodium is lost at a fast rate, whereas bicarbonate production is compromised and perhaps the body can't cope with.. copious amounts of dietary chloride salts (sodium, magnesium, calcium, etc). Hyperchloremia might play a role in edema of hypopboydism.
all there

 

[yerrag]

Check out Dr. Carolyn Dean's picometer ionic magnesium chloride product called ReMag. Best of the bunch!

While I respect Dr. Dean as she has valuable advice to give on magnesium supplementation, I'm hesitant on using ReMag because it is based on magnesium chloride. She says the magnesium in ReMag is 100% absorbed, unlike regular magnesium where only 30% of magnesium is absorbed, and about 80% of chloride absorbed, which causes it to be an acidic load. That may be a good thing. I wonder though if that means that ReMag does not create an acidic load, and so would be far superior to magnesium chloride.

If you've taken ReMag at a therapeutic dosage that's equivalent to 3 teaspons a day, or 450mg elemental magnesium (fully absorbed) per day, are you experiencing the same effects I'm experiencing as taking 4800mg mag chloride per day? I experienced very frequent urination, as a result of the kidney having to excrete plenty of chlorides in order to counter the acidic effect of the chlorides.

Are you saying it's best of the bunch out of your personal experience?

@Dave Clark: Since ReMag is apparently so highly concentrated in Mg, would it help someone who suffers from constipation, without the need to take as much as other brands?

Because the magnesium is 100% absorbed, very little is left to be excreted from the gut, so I think that it really won't help with constipation.

 

[Dave Clark]

While I respect Dr. Dean as she has valuable advice to give on magnesium supplementation, I'm hesitant on using ReMag because it is based on magnesium chloride. She says the magnesium in ReMag is 99% absorbed, unlike regular magnesium where only 30% of magnesium is absorbed, and about 80% of chloride absorbed, which causes it to be an acidic load. That may be a good thing. I wonder though if that means that ReMag does not create an acidic load, and so would be far superior to magnesium chloride.

If you've taken ReMag at a therapeutic dosage that's equivalent to 3 teaspons a day, or 450mg elemental magnesium (fully absorbed) per day, are you experiencing the same effects I'm experiencing as taking 4800mg mag chloride per day? I experienced very frequent urination, as a result of the kidney having to excrete plenty of chlorides in order to counter the acidic effect of the chlorides.

Are you saying it's best of the bunch out of your personal experience?

Because the magnesium is 99% absorbed, very little is left to be excreted from the gut, so I think that it really won't help with constipation.

Dean says that few, if any, people have loose bowels with ReMAG because it is supposed to be absorbed in the small intestine before it gets to the colon. Her formula is expensive to use regularly. I liked it because my foot cramps went away when I started using it, but that could of been just circumstance or from something else, not sure really. I was thinking about what you said about the chloride and the acid load, and I think i will give magnesium bicarbonate another try and see if my foot cramps stay away. Magnesium bicarbonate is a good form, and cheap to make. With Dean's product, I would like to see her provide more clinical studies to show how well her product really works, rather than just taking her word for it, but that doesn't mean her product isn't good, just means there is no formal proof. Also, I am going to give Magnoil a try as well to see if Haidut's formula has any different/better effects. I like to experiment and keep an open mind. I also am thinking of asking my doc to give me an RBC Mg test to see where I am at with all this.

 

[yerrag]

Dean says that few, if any, people have loose bowels with ReMAG because it is supposed to be absorbed in the small intestine before it gets to the colon. Her formula is expensive to use regularly. I liked it because my foot cramps went away when I started using it, but that could of been just circumstance or from something else, not sure really. I was thinking about what you said about the chloride and the acid load, and I think i will give magnesium bicarbonate another try and see if my foot cramps stay away. Magnesium bicarbonate is a good form, and cheap to make. With Dean's product, I would like to see her provide more clinical studies to show how well her product really works, rather than just taking her word for it, but that doesn't mean her product isn't good, just means there is no formal proof. Also, I am going to give Magnoil a try as well to see if Haidut's formula has any different/better effects. I like to experiment and keep an open mind. I also am thinking of asking my doc to give me an RBC Mg test to see where I am at with all this.

I'm also concerned about not having diarrhea or loose stools to keep magnesium toxicity in check. I seen to understand that with other forms of magnesium, we would know when to stop magnesium intake when bowel loosens too much, as that we could us from consuming excessive magnesium. Excess magnesium would lead to magnesium toxicity, and it cod be fatal as well.

I just don't know if the total availability of ReMag would keep users from experiencing loose bowels when nearing excess magnesium levels.

 

[Dave Clark]

I'm also concerned about not having diarrhea or loose stools to keep magnesium toxicity in check. I seen to understand that with other forms of magnesium, we would know when to stop magnesium intake when bowel loosens too much, as that we could us from consuming excessive magnesium. Excess magnesium would lead to magnesium toxicity, and it cod be fatal as well.

I just don't know if the total availability of ReMag would keep users from experiencing loose bowels when nearing excess magnesium levels.

If she is right, then we probably wouldn't know via loose bowels about magnesium toxicity. However, she recommends a certain dose which she feels is safe, and she also advocates for testing magnesium levels by the RBC test for accuracy. If you are relying on your bowels to tell you when to back off, I wouldn't use her ReMag, however, if you use a moderate dose of ReMag and do not have any magnesium deficiency sympotms, you will probaably be okay. You can also be aware of any magnesium toxicity symptoms as well (although, I for one do not know what they are). I wonder also that just because your bowels get loose, which means that too much Mg is in the colon, doesn't mean that you necessarily have too much systemically, that's where the RBC test comes in, it tells you how much your body has, not just your bowels, which would be a better determining factor for Mg toxicity, I would think.

 

[yerrag]

If she is right, then we probably wouldn't know via loose bowels about magnesium toxicity. However, she recommends a certain dose which she feels is safe, and she also advocates for testing magnesium levels by the RBC test for accuracy. If you are relying on your bowels to tell you when to back off, I wouldn't use her ReMag, however, if you use a moderate dose of ReMag and do not have any magnesium deficiency sympotms, you will probaably be okay. You can also be aware of any magnesium toxicity symptoms as well (although, I for one do not know what they are). I wonder also that just because your bowels get loose, which means that too much Mg is in the colon, doesn't mean that you necessarily have too much systemically, that's where the RBC test comes in, it tells you how much your body has, not just your bowels, which would be a better determining factor for Mg toxicity, I would think.

I think you're right. Loose stools may not really be the way to tell if you're reaching excessive magnesium in the body. It just tells you you've too much magnesium intake at a given time. If I take in one sitting my daily magnesium supplementation instead of spreading it over the day with the 3 meals, I could just as easily get loose stools, but it doesn't mean I have excess body stores of magnesium.

I don't really trust the RBC magnesium test. It's only better than the serum magnesium test, but the blood holds only 1% of total body magnesium, so it doesn't really say much about total body magnesium.