Magnesium and vitamin B6 effective in 40% of autism cases

haidut

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This is a continuation on my posts about vitamin B6. Ray has written about B6 and how it steers tryptophan metabolism in the direction of niacin rather than serotonin. Also, high serotonin has been detected in virtually all cases of "autism" and anti-serotonergic drugs like cyproheptadine have shown great benefit in relieving symptoms. Magnesium seems to enhance the effect of B6 on serotonin and dopamine.

http://www.ncbi.nlm.nih.gov/pubmed/1844561

"...Pharmacologic use of Mg can decrease neurologic deficit in experimental head trauma, possibly by blockade of N-methyl-D-aspartate receptors. In conjunction with high doses of pyridoxine, Mg salts benefit 40% of patients with autism, possibly by an effect on dopamine metabolism."
 

aguilaroja

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Re: Magnesium and vitamin B6 effective in 40% of autism case

The late Bernard Rimland, Ph.D., a psychologist and Autism Research Institute advocate, discussed B6 effectiveness in autism for decades, in interviews, speeches, and articles.

He repeatedly stated that there were numerous credible clinical trials for pyridoxine in autism (double blind, placebo controlled, etc.), which research-wise compared favorably to any single proprietary pharmaceutical for a single indication. I imagine that there is an extensive list in one of his articles, or in the Autism Research Institute resources, but I do not have one at hand.

I am not saying that all of Dr. Rimland's findings coincided with Dr. Peat's. Rimland was interested in Magnesium and many other nutrients. But Rimland appeared to be a thoughtful and dedicated person working for and with families who did not get substantial relief from the medical orthodoxy of the day.

http://www.biologicaltreatments.com/book/ch11.asp

http://en.wikipedia.org/wiki/Bernard_Rimland
 

Amazoniac

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- Why is vitamin B6 effective in alleviating the symptoms of autism?

Abstract said:
Many factors are reported to be involved in the complex pathophysiological processes of autism, suggesting that there is considerable variability in the manifestations of this disease. Several interventions are used to treat this disorder. Among them, vitamin B6 is widely used to treat the symptoms observed in autism. Vitamin B6 is beneficial for about half of autistic individuals in decreasing behavioral problems. However, until now, it remains unknown why vitamin B6 is effective for this disease. Although the exact pathogenesis is not defined, it is evident that certain neurotransmitter systems are impaired in the brains of autistic patients, causing the symptoms observed in the disease. In fact, impairment of many neurotransmitter systems has been reported, including GABA, serotonin, dopamine, and noradrenalin. Furthermore, vitamin B6 is important for the synthesis of many neurotransmitters, including GABA, serotonin, dopamine, noradrenalin, histamine, glycine, and d-serine, indicating that vitamin B6 supplementation may enhance many neurotransmitter systems. Thus, vitamin B6 supplementation can treat the impaired neurotransmitter systems in a given patient, even if the actual impaired neurotransmitter systems are not defined in that patient.
 

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