Lsd: Antagonizes Serotonin And Glutamate Excitation

[michael94]

http://www.ncbi.nlm.nih.gov/pubmed/5492893

LSD 25 antagonized 5-HT excitation of single neurones when applied iontophoretically or administered intravenously. LSD 25 also antagonized glutamate excitation of neurones which could be excited by 5-HT. Inhibitory effects of 5-HT, the action of glutamate on neurones which could be inhibited by 5-HT and the actions of all the other compounds tested were unaffected by LSD 25.3. Iontophoretically applied UML 491 was also a specific antagonist to 5-HT and glutamate excitation but was less potent than LSD 25, and BOL 148 rarely exhibited antagonism.4. It is suggested that antagonism to 5-HT and glutamate excitation of brain stem neurones may be the basis of the psychotomimetic action of LSD 25. It is also suggested that there may be similarities in the mechanisms by which 5-HT and glutamate produce excitation where they act on the same neurone.

 

[Makrosky]

post 113985 http://www.ncbi.nlm.nih.gov/pubmed/5492893

LSD 25 antagonized 5-HT excitation of single neurones when applied iontophoretically or administered intravenously. LSD 25 also antagonized glutamate excitation of neurones which could be excited by 5-HT. Inhibitory effects of 5-HT, the action of glutamate on neurones which could be inhibited by 5-HT and the actions of all the other compounds tested were unaffected by LSD 25.3. Iontophoretically applied UML 491 was also a specific antagonist to 5-HT and glutamate excitation but was less potent than LSD 25, and BOL 148 rarely exhibited antagonism.4. It is suggested that antagonism to 5-HT and glutamate excitation of brain stem neurones may be the basis of the psychotomimetic action of LSD 25. It is also suggested that there may be similarities in the mechanisms by which 5-HT and glutamate produce excitation where they act on the same neurone.

Good info. Thanks.

 

[Mauritio]

Another piece of the puzzle is the autoreceptor . Agonizing a serotonin receptor is generally bad ,but this is an exception .
This study says that it's anti-serotonin effects are mediated through auto receptor activation.

Autoreceptor - Wikipedia

en.m.wikipedia.org

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[Mauritio]

Wikipedia lists LSD as a partial agonist at 5ht1a

5-HT1A receptor - Wikipedia

en.m.wikipedia.org

 

[Mauritio]

Also interesting:

"The use of LSD among US adults increased 56.4% from 2015 to 2018."

(Lysergic acid diethylamide - Wikipedia)