Parsifal said:post 112951Haidut, you are saying that there is no cell receptors but how do you explain the effects on different "receptors" reported by those drugs with your paradigm?haidut said:RPDiciple said:In terms of serotonin inibition, why does cypro increase appetite in people and lead to weigh gain in many people?
I also read that paper where they did something to reduce or inhibit serotonin and made people/mouse? get teen like metabolism
For cypro, it is the antagonism of one of the serotonin receptors (I think) that causes the appetite change. The paper on serotonin showed that inhibiting peripheral serotonin via TPH-2 inhibition restored metabolism. Another way to achieve similar results is to block serotonin receptors.
The cell's energetic status and overall health of the organism determines the effects of a substance on the cell. Peat has written about this many times. Various substances like adrenaline and some fatty acids have been found to bind perfectly well to the estrogen "receptor" and activate it. Modern medicine says this is impossible and should not happen.
The dopaminergic drugs have effects similar to dopamine on the cell. Dopamine opposes the effects of serotonin and as such increases metabolism and leads to cell loss. That is my understanding at least.
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