Lower Levels Of Endotoxins And Better Gut Permeability In Centenarians VS Young People


May 11, 2020
I found this very interesting study.

Serum Zonulin and Endotoxin Levels in Exceptional Longevity versus Precocious Myocardial Infarction

Young healthy people or young people with myocardial infarction, they have higher levels of zonulin and higher levels of lipopolysaccharides (endotoxins)... than healthy centenarians without diseases !

Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysaccharide) and zonulin (a biomarker of intestinal permeability) levels and the risk of coronary heart disease, and thus healthy aging. Serum levels of zonulin, lipopolysaccharide and soluble CD14 (a protein that binds lipopolysaccharide) were measured in disease-free centenarians, young healthy controls and patients with precocious acute myocardial infarction. Disease-free centenarians had significantly lower levels of serum zonulin (P<0.01) and lipopolysaccharide (P<0.001) than young patients with acute myocardial infarction, and had significantly lower concentrations of serum lipopolysaccharide than young healthy controls (P<0.05). No significant differences were found for soluble CD14 between groups. Our findings may stimulate further research into the role played by intestinal permeability and endotoxemia not only in coronary heart disease but also in lifespan modulation."

Three groups of subjects (described in previous publications [23-27]) were analyzed: disease-free centenarians (N=79; 39 men, 40 women), non-diabetic patients aged <40 years who had experienced AMI (N=178; 101 men, 77 women), and healthy young volunteers matched to AMI patients for age and sex (N=178; 102 men, 76 women).

All subjects were Caucasian whites ascertained to be of Italian descent (Northern Italy, mainly from Lombardy and Piedmont)

Healthy young controls were volunteers who were considered to be in good health, with exclusion criteria being as follows: presence of CHD or cerebrovascular disease, cancer, dementia, chronic autoimmune/inflammatory disorders, renal or hepatic failure, and major psychiatric conditions. Their compliance with study criteria was confirmed based on their family history and results of routine blood chemistry, i.e., none had hypercholesterolemia or hyper-triglyceridemia. Further, none of them was obese or had hypertension, even though 36% were current smokers."

Serum Zonulin and Endotoxin Levels in Exceptional Longevity versus Precocious Myocardial Infarction

Sadly, we don't have a lot of informations about their diet.

"Experimental manipulation of zonulin and endotoxemia in animal models of aging and AMI, and human intervention studies are required before definite conclusions can be drawn as reverse causality cannot be firmly excluded in our study giving its observational nature. Another limitation is the lack of data on subjects’ diet and microbiota composition, since these are suspected environmental triggers of endotoxemia and zonulin expression. While we cannot yet translate our findings into clinical practice, we hope that they may inspire future studies to establish a causal link between intestinal permeability, endotoxemia and CHD."

But it remains totally insane. I saw a random article once on supposed longer telomeres in acneic people, but when we know that acne could be linked to gut permeability... minor illnesses could be a sign of a compromised longevity.
Similar threads
Thread starter Title Forum Replies Date
Mauritio Sterile gut leads to lower anxiety, serotonin , and TPH-levels + some bacteria don't increase serotonin Articles & Scientific Studies 4
Lokzo COVID‐19 pneumonia causes lower testosterone levels - PUBMED 2020 Scientific Studies 4
M How To Lower Allopregnanolone Levels Male Issues 5
rzero Breast Cancer Survivors Who Use Estrogenic Botanical Supplements Have Lower Serum Estrogen Levels Scientific Studies 20
haidut The "safe" Levels Of Thyroid Inhibitor In Tap Water Much Lower Than Previously Thought Scientific Studies 0
managing A List Of Things That Lower Carnitine Levels Supplements, Pharmaceutical Drugs 10
M Best Way To Lower Nitric Oxide Levels? Ask For Help or Advice 30
C Anyone Know How To Lower Choline Levels? Symptoms, Causes 10
T Lower Prostate Cancer Risk In Men With Elevated Plasma Lycopene Levels Cancer 0
H Brain Scan Study Adds To Evidence That Lower Brain Serotonin Levels Are Linked To Dementia Scientific Studies 5
R Lower Carbon Dioxide Levels Implied Better Sleep Depth, Sleep Efficiency, And Lesse Scientific Studies 4
japanesedude Men With Higher Levels Of Serum Testosterone Have Lower-status Occupations Miscellaneous Health Discussions 70
M Has Anyone Used Progesterone To Lower Serotonin Levels In The Brain? Progesterone 51
haidut Lower Growth Hormone (hGH) And IGF-1 Levels In Men Extends Lifespan Scientific Studies 36
raypeatclips Noradrenaline Levels Higher In Genetically Low Magnesium Rats And Lower DOPAC Scientific Studies 0
haidut The Lower Your Cortisol Levels, The Younger You Look Scientific Studies 64
haidut Optimal Levels Of TSH Are Much Lower Than Official Guidelines Scientific Studies 10
Gabriel Lower vitamin A levels in hyperthyroid patients Articles & Scientific Studies 0
N Will Pregnenolone Lower TSH Levels? Pregnenolone 3
I How to lower bp - young man with high blood pressure Heart, Heart Rate, Blood Pressure 1
V Marine PUFAs linked to lower mortality (Study) Polyunsaturated Fats, Seed Oils 4
E Lower prolactin withour raising hemoglobine Ask For Help or Advice 0
youngsinatra Can High Vitamin D Compensate Lower Dietary Calcium? Ask For Help or Advice 4
N How can I lower ACTH production due to pituitary gland tumor? Cortisol, Serotonin, Histamine 6
L Lower Belly Fat, Oily Skin & Hair Loss... Female Issues 4
Hans 8 uncommon herbs that lower prolactin and restore dopaminergic neurotransmission Articles & Scientific Studies 48
Hirri Suddenly lower Vitamin D question Vitamins 9
B Lower FFA/FAO Metabolism 17
U How to lower testosterone in women? Female Issues 17
Hans How to lower intracellular cortisol Articles & Scientific Studies 11
U How To Lower Stress Impact From Surgery? Cortisol, Serotonin, Histamine 0
D Lower And Upper Body Weakness Symptoms, Causes 0
H How To Lower High Prolactin? Blood Work, Labs 13
haidut Aspirin Has Dramatically Lower Bleeding Risk Than Pharma Anticoagulants Scientific Studies 10
lvysaur Why Does Aspirin Lower My Bilirubin? Blood Work, Labs 2
E How Can I Lower My Fever Issues? Tylenol Seems To Be The Only Option Ask For Help or Advice 45
Hgreen56 Pasta Scores Lower Insulin Index Than Fruit Diet 13
GelatinGoblin Does Sunlight Lower Thyroid And Steroids? Ask For Help or Advice 1
P Lower Abdominal Bloating From The Pill - Looking For Advice Female Issues 9
S How To Lower CAMP? Metabolism 3
F Can Thyroid Supplementation Lower Already Low Cortisol? Cortisol, Serotonin, Histamine 2
C Higher Carb To Protein Ratio Results In Higher Testosterone And Lower Cortisol In Men (1987) Scientific Studies 5
snacks Magnesium, Iodine, Butekyo All Lower Temperature Metabolism 20
Opioidus A List Of Things That Lower Or Antagonize Progesterone Selectively? Male Issues 1
Elize What Can Be Used To Lower Histamine But Not Cortisol Fruit Juice 51
Vileplume More Raw Goat Milk = Lower Temps, Even Though I Feel Good? Metabolism 8
S How Do Permanently Lower Prolactin? Male Issues 51
L Dairy-rich Diet Linked To Lower Risks Of Diabetes And High Blood Pressure Dairy 3
D Possible Ways To Lower Serotonin In Young Children Autism 10
C Temps LOWER On NDT? Ask For Help or Advice 50

Similar threads