Lower Levels Of Endotoxins And Better Gut Permeability In Centenarians VS Young People

Nuancé

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I found this very interesting study.

Serum Zonulin and Endotoxin Levels in Exceptional Longevity versus Precocious Myocardial Infarction

Young healthy people or young people with myocardial infarction, they have higher levels of zonulin and higher levels of lipopolysaccharides (endotoxins)... than healthy centenarians without diseases !

"Abstract
Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysaccharide) and zonulin (a biomarker of intestinal permeability) levels and the risk of coronary heart disease, and thus healthy aging. Serum levels of zonulin, lipopolysaccharide and soluble CD14 (a protein that binds lipopolysaccharide) were measured in disease-free centenarians, young healthy controls and patients with precocious acute myocardial infarction. Disease-free centenarians had significantly lower levels of serum zonulin (P<0.01) and lipopolysaccharide (P<0.001) than young patients with acute myocardial infarction, and had significantly lower concentrations of serum lipopolysaccharide than young healthy controls (P<0.05). No significant differences were found for soluble CD14 between groups. Our findings may stimulate further research into the role played by intestinal permeability and endotoxemia not only in coronary heart disease but also in lifespan modulation."

"
Participants
Three groups of subjects (described in previous publications [23-27]) were analyzed: disease-free centenarians (N=79; 39 men, 40 women), non-diabetic patients aged <40 years who had experienced AMI (N=178; 101 men, 77 women), and healthy young volunteers matched to AMI patients for age and sex (N=178; 102 men, 76 women).

All subjects were Caucasian whites ascertained to be of Italian descent (Northern Italy, mainly from Lombardy and Piedmont)

Healthy young controls were volunteers who were considered to be in good health, with exclusion criteria being as follows: presence of CHD or cerebrovascular disease, cancer, dementia, chronic autoimmune/inflammatory disorders, renal or hepatic failure, and major psychiatric conditions. Their compliance with study criteria was confirmed based on their family history and results of routine blood chemistry, i.e., none had hypercholesterolemia or hyper-triglyceridemia. Further, none of them was obese or had hypertension, even though 36% were current smokers."

Serum Zonulin and Endotoxin Levels in Exceptional Longevity versus Precocious Myocardial Infarction

Sadly, we don't have a lot of informations about their diet.

"Experimental manipulation of zonulin and endotoxemia in animal models of aging and AMI, and human intervention studies are required before definite conclusions can be drawn as reverse causality cannot be firmly excluded in our study giving its observational nature. Another limitation is the lack of data on subjects’ diet and microbiota composition, since these are suspected environmental triggers of endotoxemia and zonulin expression. While we cannot yet translate our findings into clinical practice, we hope that they may inspire future studies to establish a causal link between intestinal permeability, endotoxemia and CHD."

But it remains totally insane. I saw a random article once on supposed longer telomeres in acneic people, but when we know that acne could be linked to gut permeability... minor illnesses could be a sign of a compromised longevity.
 
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