Douglas Ek
Member
- Joined
- Feb 8, 2017
- Messages
- 642
Hi recently I’ve been raving about irons role in proper dopamine function. Also the importance of proper iron function. This led me to ferroxidase (ceruloplasmin) which is the primary enzyme to handle and shuttle iron through cells and transport it through out the body.
Found several studies linking lower ceruloplasmin levels in Parkinson’s disease. My question is what came first? Parkinson’s and then low ceruloplasmin or is low ceruloplasmin a causative factor for Parkinson’s and dopamine dysfunction. It does sound solid as iron deposition in brain is related to neruonal dopamine celll death in parkinson’s. Why would dopamine deposit excessivly in the brain and tissue?
Due to lower ceruloplasmin meaning the iron doesn’t have anywhere to go.
JNM | Mobile
Serum Ceruloplasmin and Striatal Dopamine Transporter Density in Parkinson Disease: Comparison With 123I-FP-CIT SPECT. - PubMed - NCBI
https://www.hindawi.com/journals/omcl/2014/147251/
”Ceruloplasmin is intimately linked to iron efflux from the brain because, as in the liver, ceruloplasmin oxidizes iron that has been previously transported by ferroportin to be incorporated into transferrin [26]. Aceruloplasminemia, a genetic condition producing a lack of function of circulating ceruloplasmin, is characterized by iron accumulation, remarkably in the brain, where it is associated with neurodegeneration and extrapyramidal parkinsonian symptoms [64]. In fact, diseases known to involve the accumulation of iron in the brain, for example, aceruloplasminemia, ferritinopathy, and a syndrome of neurodegeneration with brain iron accumulation, are characterized by neuronal death and motor manifestations similar to those of Parkinson’s disease [26].”
Found several studies linking lower ceruloplasmin levels in Parkinson’s disease. My question is what came first? Parkinson’s and then low ceruloplasmin or is low ceruloplasmin a causative factor for Parkinson’s and dopamine dysfunction. It does sound solid as iron deposition in brain is related to neruonal dopamine celll death in parkinson’s. Why would dopamine deposit excessivly in the brain and tissue?
Due to lower ceruloplasmin meaning the iron doesn’t have anywhere to go.
JNM | Mobile
Serum Ceruloplasmin and Striatal Dopamine Transporter Density in Parkinson Disease: Comparison With 123I-FP-CIT SPECT. - PubMed - NCBI
https://www.hindawi.com/journals/omcl/2014/147251/
”Ceruloplasmin is intimately linked to iron efflux from the brain because, as in the liver, ceruloplasmin oxidizes iron that has been previously transported by ferroportin to be incorporated into transferrin [26]. Aceruloplasminemia, a genetic condition producing a lack of function of circulating ceruloplasmin, is characterized by iron accumulation, remarkably in the brain, where it is associated with neurodegeneration and extrapyramidal parkinsonian symptoms [64]. In fact, diseases known to involve the accumulation of iron in the brain, for example, aceruloplasminemia, ferritinopathy, and a syndrome of neurodegeneration with brain iron accumulation, are characterized by neuronal death and motor manifestations similar to those of Parkinson’s disease [26].”