So much for T and DHT being bad for older men. More specifically, lower androgen levels and higher pituitary hormone levels were linked to higher cancer and CVD mortality.
Temporal changes in sex hormones linked to increased mortality in older men
"...Increased risk for all-cause mortality was associated with progressive declines in serum testosterone (RR = 1.18 per 1 standard deviation [SD] decline; 95% CI, 1.05-1.32), dihydrotestosterone (RR = 1.17 per 1 SD decline; 95% CI, 1.05-1.32), calculated free testosterone (RR = 1.27 per 1 SD decline; 95% CI, 1.13-1.41) and estradiol (RR = 1.46 per 1 SD decline; 95% CI, 1.3-1.63). A lower risk for all-cause mortality was seen with declining sex hormone-binding globulin (RR = 0.8 per 1 SD decline; 95% CI, 0.73-0.88), luteinizing hormone (LH; RR = 0.81 per 1 SD decline; 95% CI, 0.77-0.89) and follicle-stimulating hormone (FSH; RR = 0.85 per 1 SD decline; 95% CI, 0.77-0.94). Significant interactions were found between all-cause mortality and serum testosterone and serum estradiol levels (P = .02). Compared with intermediate/high testosterone and estradiol, combined low testosterone and low estradiol were linked to an increased risk for all-cause mortality (RR = 1.35; 95% CI, 1.06-1.72). Progressive declines in serum testosterone, dihydrotestosterone, calculated free testosterone, estradiol and LH/testosterone were linked to cancer-specific mortality, whereas SHBG, LH and FSH were not. Increased risk for cardiovascular-specific mortality was linked to declining serum testosterone, dihydrotestosterone, calculated free testosterone and estradiol, as well as increasing SHBG, LH, FSH and LH/testosterone."
Temporal changes in sex hormones linked to increased mortality in older men
"...Increased risk for all-cause mortality was associated with progressive declines in serum testosterone (RR = 1.18 per 1 standard deviation [SD] decline; 95% CI, 1.05-1.32), dihydrotestosterone (RR = 1.17 per 1 SD decline; 95% CI, 1.05-1.32), calculated free testosterone (RR = 1.27 per 1 SD decline; 95% CI, 1.13-1.41) and estradiol (RR = 1.46 per 1 SD decline; 95% CI, 1.3-1.63). A lower risk for all-cause mortality was seen with declining sex hormone-binding globulin (RR = 0.8 per 1 SD decline; 95% CI, 0.73-0.88), luteinizing hormone (LH; RR = 0.81 per 1 SD decline; 95% CI, 0.77-0.89) and follicle-stimulating hormone (FSH; RR = 0.85 per 1 SD decline; 95% CI, 0.77-0.94). Significant interactions were found between all-cause mortality and serum testosterone and serum estradiol levels (P = .02). Compared with intermediate/high testosterone and estradiol, combined low testosterone and low estradiol were linked to an increased risk for all-cause mortality (RR = 1.35; 95% CI, 1.06-1.72). Progressive declines in serum testosterone, dihydrotestosterone, calculated free testosterone, estradiol and LH/testosterone were linked to cancer-specific mortality, whereas SHBG, LH and FSH were not. Increased risk for cardiovascular-specific mortality was linked to declining serum testosterone, dihydrotestosterone, calculated free testosterone and estradiol, as well as increasing SHBG, LH, FSH and LH/testosterone."
