Low Fasting Serum Insulin And Dementia In Nondiabetic Women Followed For 34 Years

Mito

Member
Joined
Dec 10, 2016
Messages
1,898
Objective
In a representative population of women followed over 34 years, we investigated the pro- spective association between fasting serum insulin and dementia, taking into account the incidence of diabetes mellitus.

Methods
Fasting values for serum insulin and blood glucose were obtained in 1,212 nondiabetic women 38 to 60 years of age at the 1968 baseline. Risk of dementia was assessed by Cox proportional hazard regression with adjustment for insulin, glucose, and other covariates and, in a second model, after censoring for incident cases of diabetes mellitus. Incident diabetes mellitus was considered as a third endpoint for comparison with dementia.

Results
Over 34 years, we observed 142 incident cases of dementia. The low tertile of insulin displayed excess risk for dementia (hazard ratio
2.34, 95% confidence interval [CI] 1.52–3.58) compared to the medium tertile, but the high tertile of insulin did not (HR 1.28, 95% CI 0.81–2.03). These associations were also seen for dementia without diabetes comorbidity. In contrast, high but not low insulin predicted incident diabetes mellitus (115 cases) (HR 1.70, 95% CI 1.08–2.68 and HR 0.76, 95% CI 0.43–1.37, respectively).

Conclusion
A previous study reported a U-shaped association between fasting insulin and dementia in a 5- year follow-up of elderly men. Our results confirmed a nonlinear association in a female population, with high risk at low insulin values that was not attributable to preclinical dementia or impaired insulin secretion. This condition suggests a new pathway to dementia, which differs from the metabolic pathway involving diabetes mellitus.

http://n.neurology.org/content/neurology/91/5/e427.full.pdf
 

Hans

Member
Joined
Aug 24, 2017
Messages
3,240
Objective
In a representative population of women followed over 34 years, we investigated the pro- spective association between fasting serum insulin and dementia, taking into account the incidence of diabetes mellitus.

Methods
Fasting values for serum insulin and blood glucose were obtained in 1,212 nondiabetic women 38 to 60 years of age at the 1968 baseline. Risk of dementia was assessed by Cox proportional hazard regression with adjustment for insulin, glucose, and other covariates and, in a second model, after censoring for incident cases of diabetes mellitus. Incident diabetes mellitus was considered as a third endpoint for comparison with dementia.

Results
Over 34 years, we observed 142 incident cases of dementia. The low tertile of insulin displayed excess risk for dementia (hazard ratio
2.34, 95% confidence interval [CI] 1.52–3.58) compared to the medium tertile, but the high tertile of insulin did not (HR 1.28, 95% CI 0.81–2.03). These associations were also seen for dementia without diabetes comorbidity. In contrast, high but not low insulin predicted incident diabetes mellitus (115 cases) (HR 1.70, 95% CI 1.08–2.68 and HR 0.76, 95% CI 0.43–1.37, respectively).

Conclusion
A previous study reported a U-shaped association between fasting insulin and dementia in a 5- year follow-up of elderly men. Our results confirmed a nonlinear association in a female population, with high risk at low insulin values that was not attributable to preclinical dementia or impaired insulin secretion. This condition suggests a new pathway to dementia, which differs from the metabolic pathway involving diabetes mellitus.

http://n.neurology.org/content/neurology/91/5/e427.full.pdf


Saturated fats are more insulinogenic (the effect increase with chain length) than PUFAs, and that is why PUFAs increase fasting blood glucose. Lower fasting insulin, higher gluconeogenesis and consequently hyperglycemia.
 

fradon

Member
Joined
Sep 23, 2017
Messages
605
Objective
In a representative population of women followed over 34 years, we investigated the pro- spective association between fasting serum insulin and dementia, taking into account the incidence of diabetes mellitus.

Methods
Fasting values for serum insulin and blood glucose were obtained in 1,212 nondiabetic women 38 to 60 years of age at the 1968 baseline. Risk of dementia was assessed by Cox proportional hazard regression with adjustment for insulin, glucose, and other covariates and, in a second model, after censoring for incident cases of diabetes mellitus. Incident diabetes mellitus was considered as a third endpoint for comparison with dementia.

Results
Over 34 years, we observed 142 incident cases of dementia. The low tertile of insulin displayed excess risk for dementia (hazard ratio
2.34, 95% confidence interval [CI] 1.52–3.58) compared to the medium tertile, but the high tertile of insulin did not (HR 1.28, 95% CI 0.81–2.03). These associations were also seen for dementia without diabetes comorbidity. In contrast, high but not low insulin predicted incident diabetes mellitus (115 cases) (HR 1.70, 95% CI 1.08–2.68 and HR 0.76, 95% CI 0.43–1.37, respectively).

Conclusion
A previous study reported a U-shaped association between fasting insulin and dementia in a 5- year follow-up of elderly men. Our results confirmed a nonlinear association in a female population, with high risk at low insulin values that was not attributable to preclinical dementia or impaired insulin secretion. This condition suggests a new pathway to dementia, which differs from the metabolic pathway involving diabetes mellitus.

http://n.neurology.org/content/neurology/91/5/e427.full.pdf



dementia is destruction of the HIPPOCAMPUS and from what i read was the hippocampus runs on insluin. and the insulin receptors can also bind with cortisol...which why high levels of cortisol over time will shrink the hippocampus and lead to dementia because it basically starves.

there was a study that said chewing gum could protect the hippocampus since chewing gum will make the pancreas realeas some insulin and this could easily feed the hippocampus in times of stress.

so the people with high insulin have more fuel for the hippocampus even though they are at risk for diabetes.
 
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