PowertothePeatple
Member
- Joined
- Oct 15, 2015
- Messages
- 193
Do you think there is anyway to mitigate this if you wanted to take a large amount therapeutically?If you take niacin in unphysiological doses, it will mess up your substrate balance. Initially, niacin will significantly depress free fatty acids and enhance glucose oxidation. If you take too much niacin with regards to your current metabolic situation, there will be a rebound of free fatty acids to supranormal levels. If you repeat this to an extreme you'll compromise your ability to oxidize glucose and end up with chronically elevated free fatty acids. You basically end up with the exact opposite of what you wanted to achieve by taking niacin in the first place.
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The plasma free fatty acid rebound induced by nicotinic acid - PubMed
The time course of the nicotinic acid-induced changes in levels of plasma free fatty acids (FFA) was examined. The plasma FFA response of fasted dogs to graded doses of nicotinic acid was shown to be biphasic: an initial depression of the level of plasma FFA was followed by a rebound elevation...pubmed.ncbi.nlm.nih.gov
I am thinking that taking a lot of Niacinamide would essentially be like losing weight too fast which could flood your system with fats and possibly break something(like destroying your pancreas) or trigger a disease state? Am I understanding that right? What would an unphysiological dose be in your opinion?