Long-Term L-Serine Administration Reduces Food Intake And Improves Oxidative Stress And Sirt1/NFκB S

Grapelander

Member
Joined
Mar 26, 2019
Messages
1,297
Location
Sonoma County
Serine has recently been shown to reduce oxidative stress and inflammation, which, when occurring in the hypothalamus, contribute to age-related obesity.
The results showed that the administration of 0.5% (w/v) L-serine significantly reduced food intake and body weight gain during the experiment. Moreover, the administration of 0.5% L-serine decreased the concentrations of leptin, malondialdehyde, interleukin-1β, and interleukin-6, while it increased those of superoxide dismutase and glutathione, in both the serum and hypothalamus.
 

Goobz

Member
Joined
Mar 2, 2019
Messages
302
Location
Australia
Thanks for posting this. I take l-serine and it seems to have had good results for me with cognition, mood and sleep. I remember seeing this study a while ago, it's good to be reminded.

There is a guy out there with a theory about Alzheimer's, Parkinsons, and ALS being caused by a neurotoxin from blue green algae, which displaces l-serine. Taking l-serine as a supplement is his recommended protection against it. From memory, he even had a pilot study showing it dramatically slowed down ALS progression, which barely anything seems to be able to do. Anyone who is interested can google "Paul Cox" and "Alzheimer's" or "ALS" etc.
 

Elie

Member
Forum Supporter
Joined
Oct 30, 2015
Messages
815
Serine has recently been shown to reduce oxidative stress and inflammation, which, when occurring in the hypothalamus, contribute to age-related obesity.
The results showed that the administration of 0.5% (w/v) L-serine significantly reduced food intake and body weight gain during the experiment. Moreover, the administration of 0.5% L-serine decreased the concentrations of leptin, malondialdehyde, interleukin-1β, and interleukin-6, while it increased those of superoxide dismutase and glutathione, in both the serum and hypothalamus.

0.5% (w/v) is a measure of concentration, say 500 mg per 100 ml. But any idea what a daily dose would be.
 

Blossom

Moderator
Forum Supporter
Joined
Nov 23, 2013
Messages
11,032
Location
Indiana USA
@Elie, I realize this is an old post but figured I’d put it here for any future interest.
24E65809-26D4-4A87-A95D-150439F6FD27.jpeg
 

Validus

Member
Joined
May 11, 2022
Messages
263
Location
USA
Thoughts on phosphatidylserine being more optimal than just l-serine?
 

Blossom

Moderator
Forum Supporter
Joined
Nov 23, 2013
Messages
11,032
Location
Indiana USA
@Ionson, I’ve only tried L-Serine so don’t really know. Hopefully someone with knowledge/experience of both will reply. I just recently tried L-Serine based on a recommendation for sleep. Since sleep has been my Achilles Heel after working nights off and on for 20 years I’m game to try just about anything tbh. What surprised me the most was how much better I handle stress. I wasn’t expecting it but my stress management score from Fitbit improved by an average of 8-10 points within a couple days of starting it for sleep.
5CAACF6F-78A2-426D-A648-2FE910FE4494.png
E13CA339-9E7B-4C47-885E-D4C12AE4F88C.png
 

David PS

Member
Joined
Jan 5, 2016
Messages
14,675
Location
Dark side of the moon
Thoughts on phosphatidylserine being more optimal than just l-serine?

I like the idea of providing the body with the components that it needs to assemble phosphatidylserine itself. Phosphatidylserine is not always without risk the appears to be true if someone is taking certain pharmaceuticals.


Foods With Most Serine and Threonine

 

Similar threads

Back
Top Bottom