Long-Term L-Serine Administration Reduces Food Intake And Improves Oxidative Stress And Sirt1/NFκB S

Lewis Acid

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Mar 26, 2019
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Serine has recently been shown to reduce oxidative stress and inflammation, which, when occurring in the hypothalamus, contribute to age-related obesity.
The results showed that the administration of 0.5% (w/v) L-serine significantly reduced food intake and body weight gain during the experiment. Moreover, the administration of 0.5% L-serine decreased the concentrations of leptin, malondialdehyde, interleukin-1β, and interleukin-6, while it increased those of superoxide dismutase and glutathione, in both the serum and hypothalamus.
 

Goobz

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Mar 2, 2019
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Thanks for posting this. I take l-serine and it seems to have had good results for me with cognition, mood and sleep. I remember seeing this study a while ago, it's good to be reminded.

There is a guy out there with a theory about Alzheimer's, Parkinsons, and ALS being caused by a neurotoxin from blue green algae, which displaces l-serine. Taking l-serine as a supplement is his recommended protection against it. From memory, he even had a pilot study showing it dramatically slowed down ALS progression, which barely anything seems to be able to do. Anyone who is interested can google "Paul Cox" and "Alzheimer's" or "ALS" etc.
 

drk

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Oct 30, 2015
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Serine has recently been shown to reduce oxidative stress and inflammation, which, when occurring in the hypothalamus, contribute to age-related obesity.
The results showed that the administration of 0.5% (w/v) L-serine significantly reduced food intake and body weight gain during the experiment. Moreover, the administration of 0.5% L-serine decreased the concentrations of leptin, malondialdehyde, interleukin-1β, and interleukin-6, while it increased those of superoxide dismutase and glutathione, in both the serum and hypothalamus.

0.5% (w/v) is a measure of concentration, say 500 mg per 100 ml. But any idea what a daily dose would be.
 
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