Been seeing a lot of papers published on here touting the benefits aspirin has on erectile function. However, I personally am still a bit skeptical due to its lowering of ENOS and due to papers such as the one linked here. This is a fairly recent study conducted on older rats to see if the aspirin had any effects on ED. They found after several weeks that it did not change for better or worse.
"Ageing-Control rats revealed significantly decreased ICP, AUC, and ICP/MAP ratios compared to Adult-Control rats, and these effects were accompanied by reduced eNOS protein expression and lower total NO and cGMP levels; however, no difference was found in nNOS protein expression. For adult rat groups, aspirin significantly inhibited the production of 6-keto PGF1a, PGE2, and TXB2; however, it neither changed the ICP, AUC, or ICP/ MAP ratios nor altered the protein expression of eNOS, nNOS, COX-1, and COX-2"
" no significant difference was observed in the ICP (p = 0.7026), AUC (p = 0.3161), and ICP/MAP ratio (p = 0.2370) between the Adult-Control and Adult-Aspirin groups. Meanwhile, aspirin also did not significantly change the ICP (p = 0.7499), AUC (p = 0.1679), or ICP/MAP ratio (p = 0.7499) between the Ageing-Control and Ageing-Aspirin groups"
"In addition, no significant difference was found in terms of COX-2 levels"
There is a lot more that can be found at this link: Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model
I am no scientist or researcher so I am definitely open to the possibility that I am missing something big here, but to me, this study seems to laid out well and shows very little promise of aspirin helping resolve ED.
Would love more knowledgeable folks to take a gander! @haidut @Hans ?
Thanks in advance
"Ageing-Control rats revealed significantly decreased ICP, AUC, and ICP/MAP ratios compared to Adult-Control rats, and these effects were accompanied by reduced eNOS protein expression and lower total NO and cGMP levels; however, no difference was found in nNOS protein expression. For adult rat groups, aspirin significantly inhibited the production of 6-keto PGF1a, PGE2, and TXB2; however, it neither changed the ICP, AUC, or ICP/ MAP ratios nor altered the protein expression of eNOS, nNOS, COX-1, and COX-2"
" no significant difference was observed in the ICP (p = 0.7026), AUC (p = 0.3161), and ICP/MAP ratio (p = 0.2370) between the Adult-Control and Adult-Aspirin groups. Meanwhile, aspirin also did not significantly change the ICP (p = 0.7499), AUC (p = 0.1679), or ICP/MAP ratio (p = 0.7499) between the Ageing-Control and Ageing-Aspirin groups"
"In addition, no significant difference was found in terms of COX-2 levels"
There is a lot more that can be found at this link: Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model
I am no scientist or researcher so I am definitely open to the possibility that I am missing something big here, but to me, this study seems to laid out well and shows very little promise of aspirin helping resolve ED.
Would love more knowledgeable folks to take a gander! @haidut @Hans ?
Thanks in advance