Long-Term Aspirin Administration Has No Effect On Erectile Function

scoobydoo

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Jan 7, 2020
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250
Been seeing a lot of papers published on here touting the benefits aspirin has on erectile function. However, I personally am still a bit skeptical due to its lowering of ENOS and due to papers such as the one linked here. This is a fairly recent study conducted on older rats to see if the aspirin had any effects on ED. They found after several weeks that it did not change for better or worse.

"Ageing-Control rats revealed significantly decreased ICP, AUC, and ICP/MAP ratios compared to Adult-Control rats, and these effects were accompanied by reduced eNOS protein expression and lower total NO and cGMP levels; however, no difference was found in nNOS protein expression. For adult rat groups, aspirin significantly inhibited the production of 6-keto PGF1a, PGE2, and TXB2; however, it neither changed the ICP, AUC, or ICP/ MAP ratios nor altered the protein expression of eNOS, nNOS, COX-1, and COX-2"

" no significant difference was observed in the ICP (p = 0.7026), AUC (p = 0.3161), and ICP/MAP ratio (p = 0.2370) between the Adult-Control and Adult-Aspirin groups. Meanwhile, aspirin also did not significantly change the ICP (p = 0.7499), AUC (p = 0.1679), or ICP/MAP ratio (p = 0.7499) between the Ageing-Control and Ageing-Aspirin groups"

"In addition, no significant difference was found in terms of COX-2 levels"



There is a lot more that can be found at this link: Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model
I am no scientist or researcher so I am definitely open to the possibility that I am missing something big here, but to me, this study seems to laid out well and shows very little promise of aspirin helping resolve ED.

Would love more knowledgeable folks to take a gander! @haidut @Hans ?
Thanks in advance
 

Kingpinguin

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Joined
Aug 14, 2019
Messages
586
Been seeing a lot of papers published on here touting the benefits aspirin has on erectile function. However, I personally am still a bit skeptical due to its lowering of ENOS and due to papers such as the one linked here. This is a fairly recent study conducted on older rats to see if the aspirin had any effects on ED. They found after several weeks that it did not change for better or worse.

"Ageing-Control rats revealed significantly decreased ICP, AUC, and ICP/MAP ratios compared to Adult-Control rats, and these effects were accompanied by reduced eNOS protein expression and lower total NO and cGMP levels; however, no difference was found in nNOS protein expression. For adult rat groups, aspirin significantly inhibited the production of 6-keto PGF1a, PGE2, and TXB2; however, it neither changed the ICP, AUC, or ICP/ MAP ratios nor altered the protein expression of eNOS, nNOS, COX-1, and COX-2"

" no significant difference was observed in the ICP (p = 0.7026), AUC (p = 0.3161), and ICP/MAP ratio (p = 0.2370) between the Adult-Control and Adult-Aspirin groups. Meanwhile, aspirin also did not significantly change the ICP (p = 0.7499), AUC (p = 0.1679), or ICP/MAP ratio (p = 0.7499) between the Ageing-Control and Ageing-Aspirin groups"

"In addition, no significant difference was found in terms of COX-2 levels"



There is a lot more that can be found at this link: Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model
I am no scientist or researcher so I am definitely open to the possibility that I am missing something big here, but to me, this study seems to laid out well and shows very little promise of aspirin helping resolve ED.

Would love more knowledgeable folks to take a gander! @haidut @Hans ?
Thanks in advance

ICP and MAP maybe should had gotten better from the treatment. Otherwise I don’t think the study was looking at the right things. They likely assume increased nitric oxide would equall better libido. But there’s as discussed previously on the forum possibly nitric oxide is not involved. I don’t know the mechanics. Completely behind an erection. I don’t see why aspirin in healthy humans or animals should increase erection frequency and response. But I defo see how someone with health problems it would help to restore it. Erectile dysfunction tends to be connected with low testosterone, high inflammation syndromes, diabetes, cardiovascular problems. And aspirin has been shown to help all those. So in a sick person aspirin could be effective for libido. But in a healthy person I dont see why aspirin should further boost erection quality. There’s no mechanism in aspirin where it directly increases erection strength. You get my points.

and if you look at the study @haidut posted it doesnt say aspirin works in already healthy people. It works on people with erectile dysfunction. Your study doesnt mention rats with erectile dysfunction. So I assume they are healthy rats.
 

Hans

Member
Joined
Aug 24, 2017
Messages
2,717
Been seeing a lot of papers published on here touting the benefits aspirin has on erectile function. However, I personally am still a bit skeptical due to its lowering of ENOS and due to papers such as the one linked here. This is a fairly recent study conducted on older rats to see if the aspirin had any effects on ED. They found after several weeks that it did not change for better or worse.

"Ageing-Control rats revealed significantly decreased ICP, AUC, and ICP/MAP ratios compared to Adult-Control rats, and these effects were accompanied by reduced eNOS protein expression and lower total NO and cGMP levels; however, no difference was found in nNOS protein expression. For adult rat groups, aspirin significantly inhibited the production of 6-keto PGF1a, PGE2, and TXB2; however, it neither changed the ICP, AUC, or ICP/ MAP ratios nor altered the protein expression of eNOS, nNOS, COX-1, and COX-2"

" no significant difference was observed in the ICP (p = 0.7026), AUC (p = 0.3161), and ICP/MAP ratio (p = 0.2370) between the Adult-Control and Adult-Aspirin groups. Meanwhile, aspirin also did not significantly change the ICP (p = 0.7499), AUC (p = 0.1679), or ICP/MAP ratio (p = 0.7499) between the Ageing-Control and Ageing-Aspirin groups"

"In addition, no significant difference was found in terms of COX-2 levels"



There is a lot more that can be found at this link: Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model
I am no scientist or researcher so I am definitely open to the possibility that I am missing something big here, but to me, this study seems to laid out well and shows very little promise of aspirin helping resolve ED.

Would love more knowledgeable folks to take a gander! @haidut @Hans ?
Thanks in advance
This is a rat study and there are quite a few human studies showing it is effective. But like everything else, it doesn't work for everyone.
I think at worse it'll do nothing except lower estrogen driven libido and at best improve erectile function. Aspirin does increase testosterone and possible DHT and those drive libido and erections.
 

Sexypizza

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Joined
Mar 18, 2017
Messages
97
I have erectile dysfunction (from PFS) and I have tried aspirin because I want to avoid Viagra as much as possible.

I think the aspirin overall did mildly to moderately help with erection. I gained back some of my lost size while I was on it, and I was able to keep my erections for longer and on the good days as long as I like. I had to stop using the aspirin though because it made my tinnitus worse and was giving other side effects. When I stopped the aspirin I quickly lost the gains that I made. Overall I would still say that Viagra gives me better and more stable erections though.
 

SOMO

Member
Joined
Mar 27, 2018
Messages
853
I have erectile dysfunction (from PFS) and I have tried aspirin because I want to avoid Viagra as much as possible.

I think the aspirin overall did mildly to moderately help with erection. I gained back some of my lost size while I was on it, and I was able to keep my erections for longer and on the good days as long as I like. I had to stop using the aspirin though because it made my tinnitus worse and was giving other side effects. When I stopped the aspirin I quickly lost the gains that I made. Overall I would still say that Viagra gives me better and more stable erections though.

In the 70s and 80s nitrate inhalants caused thousands of cases of lung/skin cancer and immune suppression, before they were made illegal.

I wonder if in 20 years Viagra will cause a surge of lung/skin cancer cases and negative effects on the immune system of those who tried those drugs.


I know Viagra gives me a painful stuffy nose, almost as if it was causing an allergic reaction.

I do not think Viagra is safe, but it is effective. :P
 

Sexypizza

Member
Joined
Mar 18, 2017
Messages
97
In the 70s and 80s nitrate inhalants caused thousands of cases of lung/skin cancer and immune suppression, before they were made illegal.

I wonder if in 20 years Viagra will cause a surge of lung/skin cancer cases and negative effects on the immune system of those who tried those drugs.


I know Viagra gives me a painful stuffy nose, almost as if it was causing an allergic reaction.

I do not think Viagra is safe, but it is effective. :P


Yeah, its def not safe. I have noticed that viagra interferes a lot with my thyroid function. I'm taking 2 grains of thyroid and my waking temp and pulse are really good 36.5 generally and pulse from 70 to 85, and thyroid has improved my memory and cognitive function. But if I take Viagra, even in small amounts, it will very noticeably affect my memory. I have trouble remembering words and names for a few days after using it even in small doses and my waking temp and pulse will decrease for a day. It also affects my vision a lot.

I def only use it when I think I really need to and I try to avoid it as much as I can otherwise. The good thing is that it seems that the damage from it is reversible since all the problems usually go away after a week.
 

Hans

Member
Joined
Aug 24, 2017
Messages
2,717
In the 70s and 80s nitrate inhalants caused thousands of cases of lung/skin cancer and immune suppression, before they were made illegal.

I wonder if in 20 years Viagra will cause a surge of lung/skin cancer cases and negative effects on the immune system of those who tried those drugs.


I know Viagra gives me a painful stuffy nose, almost as if it was causing an allergic reaction.

I do not think Viagra is safe, but it is effective. :P
Viagra contributes to retina degeneration, stuffy nose, rash, etc., but if you look at the other side effects of excess NO, I think most people would think twice about taking Viagra.
From this article:
"NO has also been implicated in the pathology of many inflammatory diseases, including arthritis, myocarditis, colitis, and nephritis and a large number of pathologic conditions such as amyotrophic lateral sclerosis, cancer, diabetes (NO damages the beta-cells of the pancreas. iNOS knock-out mice are protected from high‐fat diet‐induced insulin resistance (R)) (R), CFS (R), osteoarthritis (R), IBD (R), and neurodegenerative diseases.

NO, in excess, also promotes migraines (R), vascular leakage, oxidizes cholesterol, is involved in angina pectoris and finally myocardial infarction, varicose veins (estrogen is also involved), hypoxia (NO-modified hemoglobin formation was inversely proportional to oxyhemoglobin saturation (R) and inhibiting NOS increases tissue oxygenation (R)), intraocular pressure, impairs detoxification, increases parathyroid hormone and aldosterone (which can lead to soft tissue calcification, fibrosis, hypertension and other vascular diseases.), promotes lipid peroxidation (by liberating iron from ferritin), causes DNA damage (R), but inhibits DNA synthesis (by binding to the iron of ribonucleotide reductase) (R) and lowers the NAD and ATP by using it to promote DNA repair (R), promotes cell death, decreased nocturnal melatonin levels and finally even calcification of the gland, which occurs with aging, activates cyclooxygenase and lipoxygenase (which generates prostaglandins and lipoxygenase, which are toxic in high concentrations) (R), contributes to skin conditions (such as psoriasis, atopic dermatitis, irritant dermatitis, allergic dermatitis, lupus erythematous, rosacea, sunburn-induced flushing, nerve-mediated flushing and skin swelling) (R), etc."

Estrogen excess can contribute to ED exactly by increasing NO too much, which causes vascular leakage.
 
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