Lisuride - Liquid Lisuride For Lab/R&D

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haidut

haidut

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Subject has been using this in 2-3 drop doses for about 5 or 6 days now. Subject has also been using cyproheptadine at night.
Subject notices more vibrant colors and lifting of brain fog/shift to a "clearer" consciousness. This is an inconsistent but welcome effect as subject has had great difficulty experiencing the world as he used to since flouroqinolone poisoning.
A frankly debilitating wave of tiredness hits the subject around 4 hours after administration, making it difficult to function. This is not altogether unpleasant, but inconvenient nonetheless. Is this due to blood sugar issues? I checked subjects blood pressure and there was no difference during this time. Can this side effect be avoided @haidut?
I would like to up the dose, but I'm afraid of the subject getting DAWS. My two main concerns with lisuride is potential exacerbation of mental illness (depression/anxiety) and withdrawal syndrome.
@haidut Have you seen any research/literature on risks of DAWS in HED going up to 200 mcg? Or would you expect a much higher dosage to give a rat permanent withdrawal symptoms?

I have never seen DAWS reported as an issue with lisuride.
 
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Dhair

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I have never seen DAWS reported as an issue with lisuride and given it is effective even at 25mcg - 50mcg doses I think it is one of the safest options out there. But still, it should be used sparingly, like all drugs.
Great. Any comments on what would cause the tiredness? Is lowering of stress hormones possible? I have seen it discussed in this thread, but I haven't seen you mention what might be causing it.
 
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Great. Any comments on what would cause the tiredness? Is lowering of stress hormones possible? I have seen it discussed in this thread, but I haven't seen you mention what might be causing it.

I don't know for sure but it is a common side effects for all dopamine agonists. It seems to dissipate with prolonged use.
 

ddjd

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putative antagonist on 5-HT2A
may also be worth mentioning that I just discovered that aspirin and cypro probably shouldn't be taken together. I didn't know that until i came across that information in another thread. Had been taking both for a while. Then I had a bad allergic reaction to some aspirin that wasn't good anymore so I'm going to stay away from the aspirin for a while.
what about lisuride and aspirin?
 

ddjd

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I think it was about 4-6 drops in one day that interfered with sleep, lots of excited thoughts about everything that wouldn't stop, but I didn't feel tired despite getting little sleep
My rat had the exact same experience. 4 drops orally at 5pm. Felt extremely lethargic but didn't sleep till 4am. Woke up at 8am and rat doesn't feel tired, after only 4 hours sleep! Rat also very constipated but I think that's a good thing as it means low Serotonin.
 

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Have people found that their rats respond better to transdermal application than oral?
 
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@haidut
Do you think lisuride may help with arterial hardening or loss of vasoreactivity?

The hardening is usually caused by cortisol and aldosterone. Anti-serotonin drugs are known to lower both of these, so in theory they should help and cyproheptadine has already been shown directly to help with that.
Cortisol And Aldosterone Cause Vascular Calcification
Cyproheptadine Prevents / Reverses Soft Tissue Calcification

Vasoreactivity is almost entirely driven by serotonin and anti-serotonin drugs are commonly used in clinical studies to study the effect of excess serotonin on blood vessels.
 

PhilParma

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A 200mcg daily dose does not increase my rat's libido to any discernible degree. Meanwhile, a single 1.25mg bromocriptine significantly increases my rat's libido. Any thoughts as to why? Is increasing lisuride dose over 200mcg a poor idea?
 

tomisonbottom

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As I mentioned in another thread, urine tests for prolactin or cortisol or other hormones cannot be used as definitive guides. They show, above all, how well you are excreting prolactin. It is prolactin int he blood that matters and that is what lisuride should lower. However, in people with liver disease even lisuride may not help. I would do some liver tests to see where you stand on that.

Would ALT, AST and albumin be the best tests to establish liver function?
 

tomisonbottom

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A 200mcg daily dose does not increase my rat's libido to any discernible degree. Meanwhile, a single 1.25mg bromocriptine significantly increases my rat's libido. Any thoughts as to why? Is increasing lisuride dose over 200mcg a poor idea?

Did you up it?

How do you think Lisuride compares to bromo for side effects?
 

PhilParma

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Did you up it?

How do you think Lisuride compares to bromo for side effects?

Lisuride has not been increased past 200 mcg. I haven't researched thoroughly enough to feel comfortable dosing my rat beyond that. I love him dearly and don't want to do him any harm. Noticeable effects have been slightly heightened perception; e.g., music sounds better, colors more vibrant. Perhaps a more motivated mindset, but it's all very subtle.

With Bromo there is nasal/sinus congestion/tightness; a compulsion to breathe out of the mouth rather than the nose. Tightness around the cranium generally. Faint headache. Significantly increased libido. Again, perhaps more motivation and focus.

As far as I can tell.
 

tomisonbottom

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Lisuride has not been increased past 200 mcg. I haven't researched thoroughly enough to feel comfortable dosing my rat beyond that. I love him dearly and don't want to do him any harm. Noticeable effects have been slightly heightened perception; e.g., music sounds better, colors more vibrant. Perhaps a more motivated mindset, but it's all very subtle.

With Bromo there is nasal/sinus congestion/tightness; a compulsion to breathe out of the mouth rather than the nose. Tightness around the cranium generally. Faint headache. Significantly increased libido. Again, perhaps more motivation and focus.

As far as I can tell.

Thanks....I noticed exactly the same side effects with bromo as well; the mouth breathing, slight headache and congestion
 
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Would ALT, AST and albumin be the best tests to establish liver function?

ALT, ALP, AST, GGT, albumin, globulin, bilirubin, PT, PTT, and a full iron/copper panel should give decent information.
 

bdawg

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@haidut - thought I owe you some feedback after testing it out on the rat

background - mild to moderate ADHD, currently supplement large doses of coffee, theanine and taurine to counteract this so should be theoretically near 'normal' now. Grandfather succumbed to parkinsons related complications
dose - 5 drops sublingual and then 2 drops sublingual 5 hours later
effect: this ***t is legitimate, substances generally do not make rat feel different - immediate brain blood-pressure related headache - this continued for the whole day and got worse with the additional 2 drops - quite a strong feeling for rat suggesting a large impact - was quite unpleasant overall despite not being very painful

Rat was home alone, so was not in a stimulating environment. What was immediately apparent:

Libido surge - mental though not physical, reduced refractory period probably due to prolactin suppression and no change in premature ejaculation - probably near the highest libido rat has experienced ever
Focus on self - reduced empathy or need for others, didn't feel like dealing with other peoples problems including fiance - just didn't care and felt like rat had no time for it
Reduced urge to partake in dopaminergic activities - for rat this is usually socialising, gaming, reading fiction or drinking - theory is that dopamine levels were already high hence reduced urge to seek it
Extremely high focus - went on a pubmed research binge for 4 hours straight with energy levels not dropping - just kept going. This level of concentration is unusual for rat
Food cravings and higher taste perception - food tasted great and had a very strong craving for a specific type of food - food cravings are very rare for rat, rat is not a foodie so its definitely the lisuride
Flat effect - Mujuro mentioned this, rat felt no anxiety or depression, just a flat feeling
Sleep - extremely unusual tiredness suddenly kicked in around 7pm (usually rat goes for a nap between 2 and 5pm) - could not physically stay up so napped for 20 minutes. then stayed up until 2am
Biological half-life - 12 hours + - feel that it is mostly removed from the system after waking up this morning - sleep was fine

I would have liked to test it out on the rats workout and also in social situations to see if it has any beneficial effects - might try a much lower dose for those, probably 1 drop

Right now I'd only use it on the rat for study/work as the main benefit was concentration, though needs to be appropriately dosed to avoid a headache

Good product anyway - would be very medicinal for people with certain conditions
 
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haidut

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Would ALT, AST and albumin be the best tests to establish liver function?

ALT, AST, ASP, GGT, PT, PTT, albumin, globulin, bilirubin are the ones that usually give a good idea of liver health.
 
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haidut

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@haidut - thought I owe you some feedback after testing it out on the rat

background - mild to moderate ADHD, currently supplement large doses of coffee, theanine and taurine to counteract this so should be theoretically near 'normal' now. Grandfather succumbed to parkinsons related complications
dose - 5 drops sublingual and then 2 drops sublingual 5 hours later
effect: this ***t is legitimate, substances generally do not make rat feel different - immediate brain blood-pressure related headache - this continued for the whole day and got worse with the additional 2 drops - quite a strong feeling for rat suggesting a large impact - was quite unpleasant overall despite not being very painful

Rat was home alone, so was not in a stimulating environment. What was immediately apparent:

Libido surge - mental though not physical, reduced refractory period probably due to prolactin suppression and no change in premature ejaculation - probably near the highest libido rat has experienced ever
Focus on self - reduced empathy or need for others, didn't feel like dealing with other peoples problems including fiance - just didn't care and felt like rat had no time for it
Reduced urge to partake in dopaminergic activities - for rat this is usually socialising, gaming, reading fiction or drinking - theory is that dopamine levels were already high hence reduced urge to seek it
Extremely high focus - went on a pubmed research binge for 4 hours straight with energy levels not dropping - just kept going. This level of concentration is unusual for rat
Food cravings and higher taste perception - food tasted great and had a very strong craving for a specific type of food - food cravings are very rare for rat, rat is not a foodie so its definitely the lisuride
Flat effect - Mujuro mentioned this, rat felt no anxiety or depression, just a flat feeling
Sleep - extremely unusual tiredness suddenly kicked in around 7pm (usually rat goes for a nap between 2 and 5pm) - could not physically stay up so napped for 20 minutes. then stayed up until 2am
Biological half-life - 12 hours + - feel that it is mostly removed from the system after waking up this morning - sleep was fine

I would have liked to test it out on the rats workout and also in social situations to see if it has any beneficial effects - might try a much lower dose for those, probably 1 drop

Right now I'd only use it on the rat for study/work as the main benefit was concentration, though needs to be appropriately dosed to avoid a headache

Good product anyway - would be very medicinal for people with certain conditions

Thanks so much for sharing.
 
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