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Lisuride - Liquid Lisuride (maleate) For Lab/research Use

Discussion in 'IdeaLabs' started by haidut, Aug 5, 2016.

  1. alywest

    alywest Member

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    Yeah, maybe it is the lungs that are working better and therefore producing better evaporation? Perhaps just overall better respiration. Sleep is amazing, too. And I haven't tried either of them orally but I will to see if there is a difference! The autistic rat probably wouldn't allow it unless it was concealed in some OJ, perhaps!
     
  2. alywest

    alywest Member

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    may also be worth mentioning that I just discovered that aspirin and cypro probably shouldn't be taken together. I didn't know that until i came across that information in another thread. Had been taking both for a while. Then I had a bad allergic reaction to some aspirin that wasn't good anymore so I'm going to stay away from the aspirin for a while.
     
  3. OP
    haidut

    haidut Member

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    There is a study somewhere on PubMed specifically with lisuride and it was the only ergot derivative devoid of fibrosis side effects. Also, see terguride below, which is basically lisuride. It is supposed to not only be safe but even reverse fibrosis of heart, lungs, liver, etc. That's why Pfizer paid $500mil for it.
    Terguride - Wikipedia
     
  4. Waynish

    Waynish Member

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    Don't think there's evidence that LSD has fibrotic effects, are there?
     
  5. JonnyCraig

    JonnyCraig Member

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    haidut for the win
     
  6. johnwester130

    johnwester130 Member

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    how ?

    is this no longer in dmso ?
     
  7. TubZy

    TubZy Member

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    Are you still using? And you still do topical right?
     
  8. JonnyCraig

    JonnyCraig Member

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    Yes. Still using. 1 drop on wrist. I don't use daily though, I tend to take weekends off.

    I just re-added oral prog and 1 drop of Tyromix (to wrist) per day.


    Do you feel lisuride is still working for you?
     
  9. jb116

    jb116 Member

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    Is this oral though or topical?
     
  10. OP
    haidut

    haidut Member

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    I think oral. To my knowledge there is no topical cyproheptadine available anywhere.
     
  11. Joeyd

    Joeyd Member

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  12. Joeyd

    Joeyd Member

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    i know this is wikipedia but it says on this page about serotonin receptors that Lisuride is actually a serotonin agonist of the 5HT-2a receptor

    5-HT receptor - Wikipedia

    i thought lisuride would be an antagonist rather than serotonin agonist
     
  13. Joeyd

    Joeyd Member

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    Sorry can you explain what you mean by punished?

    And what was the issue about Ritanserin containing fluoride?
     
  14. Elchapchapchapo

    Elchapchapchapo Member

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    I have found riatnserin to completely knock out any kind of feeling as in terms of emotions, its like everything becomes bland and dull. When talking to people feel no connection etc.
     
  15. Risingfire

    Risingfire Member

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    Now, I have both lisuride and rit. What time of that day do you take them?
     
  16. Elchapchapchapo

    Elchapchapchapo Member

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    Ritanserin before bed usually, lisuride in the morning and then at noon i think is best, lyle mcdonald has a book on bromo and in it he talks about not disrupting the dopamine homestasis, and that it is better to take before too late in evening.
     
  17. OP
    haidut

    haidut Member

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    It is mixed agonist/antagonist but its systemic effects is anti-serotonin both due to dopamine agonism (which inhibits TPH and thus serotonin synthesis) and the antagonism on other serotonin receptors. All ergot derivatives are like that and Peat wrote about the "approximate" serotonin antagonism of these drugs. But unlike other ergot derivatives like bromocriptine and especially cabergoline, lisuride is not known to cause fibrosis and in fact Pfizer is using a lisuride to treat fibrosis of heart, lungs, kidneys, etc.
     
  18. Bobber Anderson

    Bobber Anderson Member

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    No. Not even remotely similar. Amphetamines are dopamine releasers. Extreme examples of 'dopamine releasers' are recreational substances which can produce extreme amounts of euphoria. A dopamine agonist is something entirely different.
     
  19. Risingfire

    Risingfire Member

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    Thanks
     
  20. Dhair

    Dhair Member

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    Subject has been using this in 2-3 drop doses for about 5 or 6 days now. Subject has also been using cyproheptadine at night.
    Subject notices more vibrant colors and lifting of brain fog/shift to a "clearer" consciousness. This is an inconsistent but welcome effect as subject has had great difficulty experiencing the world as he used to since flouroqinolone poisoning.
    A frankly debilitating wave of tiredness hits the subject around 4 hours after administration, making it difficult to function. This is not altogether unpleasant, but inconvenient nonetheless. Is this due to blood sugar issues? I checked subjects blood pressure and there was no difference during this time. Can this side effect be avoided @haidut?
    I would like to up the dose, but I'm afraid of the subject getting DAWS. My two main concerns with lisuride is potential exacerbation of mental illness (depression/anxiety) and withdrawal syndrome.
    @haidut Have you seen any research/literature on risks of DAWS in HED going up to 200 mcg? Or would you expect a much higher dosage to give a rat permanent withdrawal symptoms?
     
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