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Lisuride - Liquid Lisuride (maleate) For Lab/R&D

Discussion in 'IdeaLabs' started by haidut, Aug 5, 2016.

  1. OP
    haidut

    haidut Member

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    I have never seen DAWS reported as an issue with lisuride and given it is effective even at 25mcg - 50mcg doses I think it is one of the safest options out there. But still, it should be used sparingly, like all drugs.
     
  2. Dhair

    Dhair Member

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    Great. Any comments on what would cause the tiredness? Is lowering of stress hormones possible? I have seen it discussed in this thread, but I haven't seen you mention what might be causing it.
     
  3. OP
    haidut

    haidut Member

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    I don't know for sure but it is a common side effects for all dopamine agonists. It seems to dissipate with prolonged use.
     
  4. Joeyd

    Joeyd Member

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    this just sounds like micro dosing lsd lol
     
  5. Ron J

    Ron J Member

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    @haidut
    Do you think lisuride may help with arterial hardening or loss of vasoreactivity?
     
  6. Joeyd

    Joeyd Member

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    what about lisuride and aspirin?
     
  7. Joeyd

    Joeyd Member

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    why is that bad for men?
     
  8. Joeyd

    Joeyd Member

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    My rat had the exact same experience. 4 drops orally at 5pm. Felt extremely lethargic but didn't sleep till 4am. Woke up at 8am and rat doesn't feel tired, after only 4 hours sleep! Rat also very constipated but I think that's a good thing as it means low Serotonin.
     
  9. Joeyd

    Joeyd Member

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    Have people found that their rats respond better to transdermal application than oral?
     
  10. Joeyd

    Joeyd Member

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    yes i think my rat might be losing weight on this also. bonus!
     
  11. OP
    haidut

    haidut Member

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    The hardening is usually caused by cortisol and aldosterone. Anti-serotonin drugs are known to lower both of these, so in theory they should help and cyproheptadine has already been shown directly to help with that.
    Cortisol And Aldosterone Cause Vascular Calcification
    Cyproheptadine Prevents / Reverses Soft Tissue Calcification

    Vasoreactivity is almost entirely driven by serotonin and anti-serotonin drugs are commonly used in clinical studies to study the effect of excess serotonin on blood vessels.
     
  12. PhilParma

    PhilParma Member

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    A 200mcg daily dose does not increase my rat's libido to any discernible degree. Meanwhile, a single 1.25mg bromocriptine significantly increases my rat's libido. Any thoughts as to why? Is increasing lisuride dose over 200mcg a poor idea?
     
  13. tomisonbottom

    tomisonbottom Member

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    Would ALT, AST and albumin be the best tests to establish liver function?
     
  14. tomisonbottom

    tomisonbottom Member

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    Did you up it?

    How do you think Lisuride compares to bromo for side effects?
     
  15. PhilParma

    PhilParma Member

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    Lisuride has not been increased past 200 mcg. I haven't researched thoroughly enough to feel comfortable dosing my rat beyond that. I love him dearly and don't want to do him any harm. Noticeable effects have been slightly heightened perception; e.g., music sounds better, colors more vibrant. Perhaps a more motivated mindset, but it's all very subtle.

    With Bromo there is nasal/sinus congestion/tightness; a compulsion to breathe out of the mouth rather than the nose. Tightness around the cranium generally. Faint headache. Significantly increased libido. Again, perhaps more motivation and focus.

    As far as I can tell.
     
  16. tomisonbottom

    tomisonbottom Member

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    Thanks....I noticed exactly the same side effects with bromo as well; the mouth breathing, slight headache and congestion
     
  17. OP
    haidut

    haidut Member

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    ALT, ALP, AST, GGT, albumin, globulin, bilirubin, PT, PTT, and a full iron/copper panel should give decent information.
     
  18. bdawg

    bdawg Member

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    @haidut - thought I owe you some feedback after testing it out on the rat

    background - mild to moderate ADHD, currently supplement large doses of coffee, theanine and taurine to counteract this so should be theoretically near 'normal' now. Grandfather succumbed to parkinsons related complications
    dose - 5 drops sublingual and then 2 drops sublingual 5 hours later
    effect: this ***t is legitimate, substances generally do not make rat feel different - immediate brain blood-pressure related headache - this continued for the whole day and got worse with the additional 2 drops - quite a strong feeling for rat suggesting a large impact - was quite unpleasant overall despite not being very painful

    Rat was home alone, so was not in a stimulating environment. What was immediately apparent:

    Libido surge - mental though not physical, reduced refractory period probably due to prolactin suppression and no change in premature ejaculation - probably near the highest libido rat has experienced ever
    Focus on self - reduced empathy or need for others, didn't feel like dealing with other peoples problems including fiance - just didn't care and felt like rat had no time for it
    Reduced urge to partake in dopaminergic activities - for rat this is usually socialising, gaming, reading fiction or drinking - theory is that dopamine levels were already high hence reduced urge to seek it
    Extremely high focus - went on a pubmed research binge for 4 hours straight with energy levels not dropping - just kept going. This level of concentration is unusual for rat
    Food cravings and higher taste perception - food tasted great and had a very strong craving for a specific type of food - food cravings are very rare for rat, rat is not a foodie so its definitely the lisuride
    Flat effect - Mujuro mentioned this, rat felt no anxiety or depression, just a flat feeling
    Sleep - extremely unusual tiredness suddenly kicked in around 7pm (usually rat goes for a nap between 2 and 5pm) - could not physically stay up so napped for 20 minutes. then stayed up until 2am
    Biological half-life - 12 hours + - feel that it is mostly removed from the system after waking up this morning - sleep was fine

    I would have liked to test it out on the rats workout and also in social situations to see if it has any beneficial effects - might try a much lower dose for those, probably 1 drop

    Right now I'd only use it on the rat for study/work as the main benefit was concentration, though needs to be appropriately dosed to avoid a headache

    Good product anyway - would be very medicinal for people with certain conditions
     
  19. OP
    haidut

    haidut Member

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    ALT, AST, ASP, GGT, PT, PTT, albumin, globulin, bilirubin are the ones that usually give a good idea of liver health.
     
  20. OP
    haidut

    haidut Member

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    Wow, great feedback! Thanks so much for sharing. I think the increase in taste (and maybe smell??), as well as focus and libido are the most widely acknowledged signs of higher dopamine (or lower serotonin). The tiredness is also well-documented with dopamine agonists. I personally experience the same effects from just 100mcg lisuride and cannot really take more without getting the more unpleasant side effects like headache and nausea. Did you get nausea?
     
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