Mauritio
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- Feb 26, 2018
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A trait of highly successful people is to choose a bigger long-term reward over a smaller short-term reward. The ability control your emotions and impulses.
A process known as delayed gratification.
The study explains the issue, instant gratification, like this: "...the preference for an immediate small reinforcer (SR) over a delayed large reinforcer (LR)."
If you simply follow your impulses in our modern society, you probably end up beeing addicted to one of the common short term pleasure seeking things, like social media , porn or TV. A vicious cycle leading to a continuous narrowing of the things/devices/activieties, that bring you pleasure, through the downregulation of the dopamine receptors. Which in turn causes a continuously smaller dopamine peak from the same activity.
In one word: addiction.
Anyway... controlling your impulses is important.
This study shows that lisuride leads to rats making less impulsive choices.
On the other hand administration of a 5HT-2a agonist increased impulsivity, which was blocked by giving a 5HT2a receptor antagonist (ketanserin).
In light of this study it makes sense how anti-serotonin chemicals like cyproheptadine, lisuride or ketanserin help people treat addictions ,since they help them not making the bad impulsive choice, whatever that may be.
Human equivalent doses of lisuride were between 1-7mg so they are relatively easily achievable by supplementation.
Would be interesting to know if people tend to indulge in instant gratification things less when taking lisuride.
"DOI (0.5 and 1.0 mg/kg) increased impulsive decision-making, and the effects of DOI (1.0 mg/kg) were blocked by the 5-HT2A receptor antagonist ketanserin (1.0 mg/kg) rather than the 5-HT2C receptor antagonist SB-242084 (1.0 mg/kg). Contrarily, lisuride (0.1, 0.3, and 0.5 mg/kg) decreased impulsive decision-making. The effects of lisuride (0.3 mg/kg) were not antagonized by ketanserin (1.0 mg/kg), selective 5-HT1A antagonist WAY-100635 (1.0 mg/kg), or selective dopamine D4 receptor antagonist L-745870 (1.0 mg/kg) but were attenuated by the selective dopamine D2/D3 receptor antagonist tiapride (40 mg/kg)."
- Contrasting effects of DOI and lisuride on impulsive decision-making in delay discounting task - PubMed
A process known as delayed gratification.
The study explains the issue, instant gratification, like this: "...the preference for an immediate small reinforcer (SR) over a delayed large reinforcer (LR)."
If you simply follow your impulses in our modern society, you probably end up beeing addicted to one of the common short term pleasure seeking things, like social media , porn or TV. A vicious cycle leading to a continuous narrowing of the things/devices/activieties, that bring you pleasure, through the downregulation of the dopamine receptors. Which in turn causes a continuously smaller dopamine peak from the same activity.
In one word: addiction.
Anyway... controlling your impulses is important.
This study shows that lisuride leads to rats making less impulsive choices.
On the other hand administration of a 5HT-2a agonist increased impulsivity, which was blocked by giving a 5HT2a receptor antagonist (ketanserin).
In light of this study it makes sense how anti-serotonin chemicals like cyproheptadine, lisuride or ketanserin help people treat addictions ,since they help them not making the bad impulsive choice, whatever that may be.
Human equivalent doses of lisuride were between 1-7mg so they are relatively easily achievable by supplementation.
Would be interesting to know if people tend to indulge in instant gratification things less when taking lisuride.
"DOI (0.5 and 1.0 mg/kg) increased impulsive decision-making, and the effects of DOI (1.0 mg/kg) were blocked by the 5-HT2A receptor antagonist ketanserin (1.0 mg/kg) rather than the 5-HT2C receptor antagonist SB-242084 (1.0 mg/kg). Contrarily, lisuride (0.1, 0.3, and 0.5 mg/kg) decreased impulsive decision-making. The effects of lisuride (0.3 mg/kg) were not antagonized by ketanserin (1.0 mg/kg), selective 5-HT1A antagonist WAY-100635 (1.0 mg/kg), or selective dopamine D4 receptor antagonist L-745870 (1.0 mg/kg) but were attenuated by the selective dopamine D2/D3 receptor antagonist tiapride (40 mg/kg)."
- Contrasting effects of DOI and lisuride on impulsive decision-making in delay discounting task - PubMed
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