List Of MAO Inhibiting Supplements?

[Sospian]

I take a lot of supplements for a variety of reasons, from supplementing micronutrients to increasing testosterone and ATP.

Unfortunately I also suffer from mild autism to which going gluten free and supplementing L. Reuteri have been absolutely game-changers.

With that in mind, last year I stupidly took large doses of St John's Wort daily as it seemed to alleviate my brain fog. I'm talking about up to 3g a day, alongside 2g of Ashwaghanda.

Since then I've been experiencing many symptoms of high serotonin that have amplified a particular part of my autism. Things no longer seem clear to me.

To put it into perspective, things feel unfocused as if I should be wearing glasses; problem being that there's nothing wrong with my eyesight.

Anyway, after checking out Han's Men Elite page on lowering serotonin, one thing hit me.

I'm more than certain that some of the supplements I'm taking contain MAO inhibitors, preventing my body's ability to brain down excess serotonin.


Does anyone have a list of MAOI supplements as I think it would be helpful for anyone including myself in avoiding excess serotonin, which could be deadly.

Thanks

 

[Estradiol]

Selegiline inhibits MAO-B and it should be used in low doses.

Memantine inhibits both A and B.

 

[Frankdee20]

I take a lot of supplements for a variety of reasons, from supplementing micronutrients to increasing testosterone and ATP.

Unfortunately I also suffer from mild autism to which going gluten free and supplementing L. Reuteri have been absolutely game-changers.

With that in mind, last year I stupidly took large doses of St John's Wort daily as it seemed to alleviate my brain fog. I'm talking about up to 3g a day, alongside 2g of Ashwaghanda.

Since then I've been experiencing many symptoms of high serotonin that have amplified a particular part of my autism. Things no longer seem clear to me.

To put it into perspective, things feel unfocused as if I should be wearing glasses; problem being that there's nothing wrong with my eyesight.

Anyway, after checking out Han's Men Elite page on lowering serotonin, one thing hit me.

I'm more than certain that some of the supplements I'm taking contain MAO inhibitors, preventing my body's ability to brain down excess serotonin.


Does anyone have a list of MAOI supplements as I think it would be helpful for anyone including myself in avoiding excess serotonin, which could be deadly.

Thanks

Saint Johns Wort definitely has an MAOI mechanism, so does Syrian Rue, so does Passionflower, so does Rhodiola

 

[boris]

Methylene Blue

 

[fever257]

Cyproheptadine is widely regarded as one the best anti-serotonin drugs out there. It requires a prescription in the United States though.

 

[golder]

Selegiline inhibits MAO-B and it should be used in low doses.

Memantine inhibits both A and B.

Presumably, it would be better to just use Memantine/Adamantine then, seeing as it offers more comprehensive inhibtition of MAO than Selegiline? What instancesdo you think it would be more worthwhile to use Selegiline only?

 

[Perry Staltic]

S-adenosyl-L-methionine, curcumin, ginseng, nutmeg, turmeric, melatonin , St. John’s wort

Table 2

Detecting and Managing Serotonin Syndrome - Psychiatry Advisor

When combined with other serotonergic agents, selective serotonin reuptake inhibitors can lead to a potentially fatal condition called serotonin syndrome, the incidence of which is likely underestimated.

www.psychiatryadvisor.com

 

[PeskyPeater]

Like SSRI Ashwaganda decreases the serotonin feedback system called 5-ht1a. -link , with no or less activating that 5ht1a system the serotonin levels don't go down.

You can see that when control mice get a 5-HT1A agonist, their serotonin levels decrease, the 5-HT1A agonist is promoting feedback and the raphe is ceasing serotonin production. But in the 5-HT1A knockout and the ones getting the small interfering RNA, serotonin levels stayed normal. There's no feedback to give, no 5-HT1A receptors to give it. - source

So increasing its [5-ht1a autoreceptor] expression or sensitivity could maybe be helpful to alleviate high serotonin symptoms.
I know that ginger is a partial 5ht1a agonist -edit- but it's vacoconstrictive . And blue lotus extract increases 5ht1a.
In traditional chinese med there is also Gou Teng that is partial 5ht1a agonist that could modulate that system.

-Cheers

 

[maillol]

I think you mean you want MAO increasing substances, not inhibitors, if you want to increase the breakdown of serotonin. Riboflavin does this as it is the cofactor for the enzyme. Be careful as it increases both MAO-A and MAO-B so it will also degrade dopamine. It always makes me depressed.

 

[aliml]

List of MAOIs​

Nonselective MAO-A and MAO-B inhibitors​

• Naturally occurring sources

Natural occuring source	Chemical
Banisteriopsis caapi (ayahuasca, caapi or yagé)	(−)-epicatechin[35]	MAO-B
Banisteriopsis caapi (ayahuasca, caapi or yagé)	(−)-procyanidins[35]	MAO-B
Banisteriopsis caapi (ayahuasca, caapi or yagé)	Harmaline[35]	RIMA
Banisteriopsis caapi (ayahuasca, caapi or yagé)	Harmine[35]	MAO-A, MAO-B
Black pepper (Piper nigrum)	Piperine[36]	MAO-A, MAO-B
Cannabis, Cannabis extract		MAO-A, MAO-B[37]
Cocoa bean (from Theobroma cacao)	Caffeine[38]	MAO-A, MAO-B[39]
Cocoa bean (from Theobroma cacao)	Catechin[40][41]	MAO-B[42]
Cocoa bean (from Theobroma cacao)	Epicatechin[43][41]	MAO-B[42]
Cocoa bean (from Theobroma cacao)	Tetrahydro-beta-carbolines[44]
Coffee (Coffea arabica, Coffea canephora)	Caffeine	MAO-A, MAO-B[39]
Coffee (Coffea arabica, Coffea canephora)	Harman[45]	MAO-A, MAO-B[46]
Coffee (Coffea arabica, Coffea canephora)	Norharman[45]	MAO-A, MAO-B[47]
Liquorice/licorice (Glycyrrhiza Glabra)	Isoliquiritigenin[17]	MAO-A, MAO-B
Liquorice/licorice (Glycyrrhiza Glabra)	Liquiritigenin[17]	MAO-A, MAO-B
Long pepper (Piper longum)	Piperine[36]	MAO-A, MAO-B
Nutmeg (Myristica fragrans)	Kaempferol[48]	MAO-A
Nutmeg (Myristica fragrans)	Myristicin	MAO-A, MAO-B?[49]
Nutmeg (Myristica fragrans)	Quercetin[50]	MAO-A
Passionflower (Passiflora incarnata), weak MAOI	Apigenin	MAO-A
Passionflower (Passiflora incarnata), weak MAOI	Harmine	MAO-A, MAO-B
Passionflower (Passiflora incarnata), weak MAOI	Kaempferol	MAO-A
Passionflower (Passiflora incarnata), weak MAOI	Quercetin	MAO-A
Rhodiola rosea		MAO-A, MAO-B[51]
Syrian rue (Peganum harmala)	Harmaline	RIMA
Syrian rue (Peganum harmala)	Harman	MAO-A, MAO-B[46]
Syrian rue (Peganum harmala)	Harmine	MAO-A, MAO-B
Tobacco	1,2,3,4-tetrahydro-b-carboline (THbC)[37]	MAO-A, MAO-B
Tobacco	1,2,3,4-tetrahydroisoquinoline[37]	MAO-A, MAO-B
Tobacco	Harman[52]	MAO-A, MAO-B[46]
Tobacco	Norharman[52]	MAO-A, MAO-B[47]

• Psychedelics
  • AET[53]
  • AMT[53]
• Pharmaceuticals
  • Hydrazine (antidepressant)
    • Isocarboxazid (Marplan)
    • Nialamide (Niamid)
    • Phenelzine (Nardil, Nardelzine)
    • Hydracarbazine
  • Non-hydrazines
    • Tranylcypromine (Parnate, Jatrosom)

Selective MAO-A inhibitors​

For safer MAO-A inhibitors, see RIMA.

• Naturally occurring sources
  • Betel nut (Areca catechu): MAO-A inhibitor.[54][37]
  • Yohimbe (Pausinystalia johimbe): Yohimbine[55]
• Psychedelics
  • 2C-T-2 (suspected, weak)[56]
  • 2C-T-7 (suspected, strong)[56]
  • Bromo-DragonFLY (suspected, very strong)[57]
• Pharmaceuticals
  • Bifemelane (Alnert, Celeport) (available in Japan)
  • Isocarboxazid (common brand name Marplan)
  • Phenelzine (common brand name Nardil)
  • Pirlindole (Pirazidol) (available in Russia)
  • Tranylcypromine (common brand name Parnate)

Selective MAO-B inhibitors​

• Naturally occurring sources
  • Kava (Piper methysticum): Yangonin. Kava pyrones: The order of potency was desmethoxyyangonin > (+/-)-methysticin > yangonin > (+/-)-dihydromethysticin > (+/-)- dihydrokavain > (+/-)-kavain.[58]
  • Olives (Olea europaea), fresh, olive leaf extract: The selective MAO-B inhibitor hydroxytyrosol.[59]
• Pharmaceuticals
  • Rasagiline (Azilect)
  • Selegiline (Deprenyl, Eldepryl, Emsam, Zelapar)
  • Safinamide (Xadago)

Unknown selectivity​

• Psychedelics
  • 5-MeO-AET
  • 5-MeO-AMT
  • 5-Fluoro-AMT
• Stimulants
  • 4-MTA
  • 5-IT
  • PMA
  • PMMA
  • PMEA
  • 4-HO-DTBT

Research​

• Naturally occurring sources
  • Mimosa tenuiflora: As there have been no MAO inhibitors detected in M. tenuiflora, there is ongoing interest into how yurema exerts its visionary effects.[60]

MAOI

Monoamine oxidase inhibitors (also known as MAOIs) are a class of drugs which inhibit the activity of the monoamine oxidase enzyme family. They have a long history of use as medications prescribed for the treatment of depression and are particularly effective in treating atypical depression.[1]...

psychonautwiki.org

 

[PeskyPeater]

nice list!
Only, it's not clear if these effects are in vitro or in vivo. I think rhodiola had in vitro MOA inhibition but not in vivo.

btw, psychonautwiki is a cool very useful website especially when dealing with drugs, medicin or recreative :)

 

[PeskyPeater]

I take a lot of supplements for a variety of reasons, from supplementing micronutrients to increasing testosterone and ATP.

Unfortunately I also suffer from mild autism to which going gluten free and supplementing L. Reuteri have been absolutely game-changers.

With that in mind, last year I stupidly took large doses of St John's Wort daily as it seemed to alleviate my brain fog. I'm talking about up to 3g a day, alongside 2g of Ashwaghanda.

Since then I've been experiencing many symptoms of high serotonin that have amplified a particular part of my autism. Things no longer seem clear to me.

To put it into perspective, things feel unfocused as if I should be wearing glasses; problem being that there's nothing wrong with my eyesight.

Anyway, after checking out Han's Men Elite page on lowering serotonin, one thing hit me.

I'm more than certain that some of the supplements I'm taking contain MAO inhibitors, preventing my body's ability to brain down excess serotonin.


Does anyone have a list of MAOI supplements as I think it would be helpful for anyone including myself in avoiding excess serotonin, which could be deadly.

Thanks

What stands out: Ashwagandha has similar effects to SSRI, it desensitizes the 5HT1a feedback system.

I think when MOA-A cause trouble especially in the brain, it could well be there is a genetic expression of SERT Serotonin transporter allele short, meaning having not much transporters, a low expression.
So then you can imagine, having a short SERT allele and using MOA-A, it induces excessive amounts of serotonin with weird effects.

 

[PeskyPeater]

SSRI induced serotonin transporter degradation - now reversible

In my thread you can find way's to resolve serotonin issues of the brain, check it out

 

[Elie]

nice list!
Only, it's not clear if these effects are in vitro or in vivo. I think rhodiola had in vitro MOA inhibition but not in vivo.

btw, psychonautwiki is a cool very useful website especially when dealing with drugs, medicin or recreative :)

Hi PeskyPeater
Do you have a link or reference for in vivo evaluation of Rhodiola's MOA inhibitory action (or lack of)?

 

[PeskyPeater]

Hi PeskyPeater
Do you have a link or reference for in vivo evaluation of Rhodiola's MOA inhibitory action (or lack of)?

nope, was long time ago sorry