Adrenaline
Member
- Joined
- Sep 9, 2019
- Messages
- 96
Lidocaine inhibits noradrenaline release and shortens action potential durations.
That's a great combination because heart failure patients have high noradrenaline levels and (generally) prolonged cardiac action potential.
Propranolol and lidocaine inhibit neural norepinephrine release in hearts with increased extracellular potassium and ischemia. - PubMed - NCBI
CONCLUSIONS: These data indicate that propranolol and lidocaine inhibit neural norepinephrine release via a Na+ channel-blocking mechanism that is synergistic with changes induced by ischemia, primarily raised extracellular K+. This mechanism may contribute to the anti-ischemic and antiarrhythmic properties of both agents in acute myocardial ischemia
That's a great combination because heart failure patients have high noradrenaline levels and (generally) prolonged cardiac action potential.
Propranolol and lidocaine inhibit neural norepinephrine release in hearts with increased extracellular potassium and ischemia. - PubMed - NCBI
CONCLUSIONS: These data indicate that propranolol and lidocaine inhibit neural norepinephrine release via a Na+ channel-blocking mechanism that is synergistic with changes induced by ischemia, primarily raised extracellular K+. This mechanism may contribute to the anti-ischemic and antiarrhythmic properties of both agents in acute myocardial ischemia