Licorice root fights CoViD19

Motif

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863127

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I made a little excerpt summary of the original paper the first article is about.

Glycyrrhizin effectively neutralizes SARS-CoV-2 in vitro by inhibiting the viral main protease

L. van de Sand, M. Bormann, M. Alt, L. Schipper, C.S. Heilingloh, D. Todt, U. Dittmer, C. Elsner, O. Witzke, A. Krawczyk

Glycyrrhizin effectively neutralizes SARS-CoV-2 in vitro by inhibiting the viral main protease

"We demonstrated that glycyrrhizin, the primary active ingredient of the licorice root, potently neutralizes SARS-CoV-2 by inhibiting the viral main protease...

In the present study, we investigated aqueous licorice root extract for its neutralizing activity against SARS-CoV-2 in vitro... The neutralization capacity of licorice root extract was determined in cell culture by endpoint dilution.... The aqueous licorice root extract showed neutralizing effects even at a subtoxic concentration of 2 mg/ml, (Figure 1A and B). This concentration is lower than the normal consuming dilution e.g. in tea (12.5 mg/ml).

Based on our results with the aqueous licorice root extract, we investigated the antiviral activity of glycyrrhizin acid against a clinical SARS-CoV-2 isolate and subsequently examined the underlying mechanism of viral neutralization.

The neutralizing activity of glycyrrhizin against a clinical SARS-CoV-2 isolate was investigated in cell culture... The neutralization capacity of glycyrrhizin was determined by endpoint dilution. The antiviral activity against SARS-CoV-2 was analysed under pre- and post-entry conditions... Complete virus neutralization was achieved at subtoxic concentrations of 0.5 mg/ml under pre- and 1 mg/ml under post-entry conditions...

The initial finding was supported by quantifying the SARS-CoV-2 RNA from the supernatants of SARS-CoV-2 infected cells treated with glycyrrhizin... Glycyrrhizin treatment significantly reduced the genomic SARS-CoV-2 RNA levels...

Next, we investigated the underlying mechanism how glycyrrhizin may interfere with the virus replication... we focused on the SARS-CoV-2 main protease (Mpro) as a potential target for glycyrrhizin. Mpro is essential for processing the viral polyproteins that are translated from the viral RNA and thus, for virus replication. Glycyrrhizin was suggested as a possible inhibitor of Mpro by in silico analysis, but this hypothesis has never been experimentally proven... Here we provide evidence that glycyrrhizin potently inhibits Mpro activity in vitro... Glycyrrhizin completely inhibited Mpro activity at a concentration of 2000 µM (1.6 mg/ml) and reduced its activity by 70.3% at a concentration of 30 µM (0.024 mg/ml)."
 
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Motif

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I googled it because somebody said early use of it and gargling it might prevent that much of the virus enters the cells or something like that.
 

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