Let's Talk About Nocturnal Penile Tumescence

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vulture

vulture

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If NPT (night erections) are good then it is unlikely that nerve damage is present and any ED issues are probably psychological. After all, nocturnal erections are a proof that nothing is wrong "down there" physiologically, so what remains is the stress response in people with highly active parasympathetic system. The latter can cause a variety of symptoms like sweaty palms, social anxiety, stuttering, and of course ED. For those people, anticholinergic chemicals like cypro or Benadryl may help. Peat spoke about this in one recent in interview, making a connection between ED and premature ejaculation, and overactive parasympathetic system. He also suggested vitamin B6 may help too.
Don’t you mean sympathetic? I was also considering that: there was a device supposed to measure parasympathetic vs sympathetic balance on CNS that was brought to my office and stated I was too much on the sympathetic side.
Fight or flight system seems pretty far from sex and erections (stressed vs relaxed).
 

haidut

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Don’t you mean sympathetic? I was also considering that: there was a device supposed to measure parasympathetic vs sympathetic balance on CNS that was brought to my office and stated I was too much on the sympathetic side.
Fight or flight system seems pretty far from sex and erections (stressed vs relaxed).

No, I meant parasympathetic. Anti-adrenaline (anti-sympathetic) drugs like beta blockers are well known to produce ED. If you Google "beta blocker ED" you will see tons of studies on the topic.
 
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I disagree that if nighttime erections are happening, ED has to be psychological.

There are many types of erections. And it is true that the penis is capable of an erection if it becomes erect at night. But there are physiological problems that can prevent erections for sex. Brain scans reveal that some men have very few neurons firing in sexual brain areas. Their erections may happen more at the spinal chord level and not in the brain.

I think poor masturbati0n habits and porn use can cause this, but it seems physical, not psychological.
 
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This is my experience as well. Until late last year my test was in the dumps and I hadn't gotten morning wood for around 3 or more years. Fast forward to now , I am much healthier and morning erections are almost painful lol. My test levels are also dramatically improved, there's totally a correlation. Funny you mention oysters, I can't eat them anymore but when I started supplementing Zinc to assure a good copper ratio was the first time I noticed my morning erections to be improved. Although too much of it has suppressed them in the past (along with every other supplement) so I mostly just represent all nutrients with diet now.

what happens if you eat them
 

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I disagree that if nighttime erections are happening, ED has to be psychological.

There are many types of erections. And it is true that the penis is capable of an erection if it becomes erect at night. But there are physiological problems that can prevent erections for sex. Brain scans reveal that some men have very few neurons firing in sexual brain areas. Their erections may happen more at the spinal chord level and not in the brain.

I think poor masturbati0n habits and porn use can cause this, but it seems physical, not psychological.

What would be the physiological problem preventing erections on demand while allowing them to occur spontaneously?
 
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What would be the physiological problem preventing erections on demand while allowing them to occur spontaneously?

II think it's that the brain simply isn't receiving signals from the penile nerves. There is a loss of sensitivity that can occur with age, or with porn/masturbation. And the loss of sensitivity applies to erections during consciousness. It can be 90% loss, which is not uncommon.

The "chord" erections can be stopped by this also, but often they can continue when the brain isn't getting much of a signal from the penis, during or before sex, so a man can't get an erection when conscious, but will get nighttime erections.

So if a man isn't getting night time erections, and can't get an erection while conscious, the penile fibrosis can be implicated. Especially when low T has been a factor for a long time. This happens a lot for men who go into a downward spiral of prostate inflammation, low T, and often prostate surgery and intentional androgen deprivation "therapy."

If a man is getting nighttime erections, he may be suffering from this physiological loss of sensitivity and that may stop him from getting erections while conscious.

I have studies somewhere backing this all up, more or less.
 
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II think it's that the brain simply isn't receiving signals from the penile nerves. There is a loss of sensitivity that can occur with age, or with porn/masturbation. And the loss of sensitivity applies to erections during consciousness. It can be 90% loss, which is not uncommon.

The "chord" erections can be stopped by this also, but often they can continue when the brain isn't getting much of a signal from the penis, during or before sex, so a man can't get an erection when conscious, but will get nighttime erections.

So if a man isn't getting night time erections, and can't get an erection while conscious, the penile fibrosis can be implicated. Especially when low T has been a factor for a long time. This happens a lot for men who go into a downward spiral of prostate inflammation, low T, and often prostate surgery and intentional androgen deprivation "therapy."

If a man is getting nighttime erections, he may be suffering from this physiological loss of sensitivity and that may stop him from getting erections while conscious.

I have studies somewhere backing this all up, more or less.
Is there a way to increase sensitivity again?
I remember when taking proviron that I felt more sensible and pleasant sensations on the glans
 
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Is there a way to increase sensitivity again?
I remember when taking proviron that I felt more sensible and pleasant sensations on the glans

sensitivity can increase and decrease all the time. But to create lasting sensitivity I think sexual habits need to be changed.
 

Jon

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Lol this is probably too much for this forum but jelqing can prevent fibrosis if one is un able to get erections. It may even reverse ed. Plus it has the added benefit of enlarging your member lol extreme caution and a conservative approach is advised, you can and will hurt yourself if you try to do too much from the biggining and it's not fun.
 

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Aleeri

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If NPT (night erections) are good then it is unlikely that nerve damage is present and any ED issues are probably psychological. After all, nocturnal erections are a proof that nothing is wrong "down there" physiologically, so what remains is the stress response in people with highly active parasympathetic system. The latter can cause a variety of symptoms like sweaty palms, social anxiety, stuttering, and of course ED. For those people, anticholinergic chemicals like cypro or Benadryl may help. Peat spoke about this in one recent in interview, making a connection between ED and premature ejaculation, and overactive parasympathetic system. He also suggested vitamin B6 may help too.

@haidut do you have any more information or tips what can be done concerning this? For example, link to the interview Peat spoke about this?

I have exactly these issues. I have very strong nightly erections, high androgen levels and my estrogen is balanced as well. I do not really suffer from ED but my erections are not very good at times and take a long time to get going. I also have mild premature ejaculation, it is difficult for me to get erections going and when I do it's too easy for me to finish.

I think it has to do with overactive sympathetic since I easily stress and have some mild degree of social anxiety.

I tried Cypro before and it definitely makes me feel "normal" nervous system wise, normalizes stress. But even at 0.5mg it really wipes me out and makes me very unproductive and unmotivated. I could not keep taking it because my work suffers.

I've been recommended Agomelatine by Joe over at Selfhacked.com that I should try to decrease my 5-HT2C receptors since I seem to have genetics that upregulate these, have not tried it though. Is this relevant? I know they are serotonin receptors.
 

Aleeri

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Trying to make sense of this from my experience...

Lisuride = much improved sexual functioning (libido, erections, morning wood etc) for first week or two...tapered off a bit after that but still good.

To the comment above, lisuride also gave me MUCH improved bowel movements, and I thought they were already fine. Could be a connection.

Oxidal = lowered sexual functioning by all the same parameters above. I assumed it was because nitric oxide was lowered by oxidal, but that doesn’t line up with what you’ve said here.

Interesting, I asked about Oxidal and erections in the Oxidal thread, there is a rat study that shows reduced erectile quality from MB.

I've been very curious about trying Lisuride but concerned about it's safety longterm.
 

haidut

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Interesting, I asked about Oxidal and erections in the Oxidal thread, there is a rat study that shows reduced erectile quality from MB.

I've been very curious about trying Lisuride but concerned about it's safety longterm.

As far as I can remember, the dose of methylene blue used in these studies to hinder erection was high. I think it was in the 20mg-30mg range as a single dose, which is not something most people use.
 

haidut

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@haidut do you have any more information or tips what can be done concerning this? For example, link to the interview Peat spoke about this?

I have exactly these issues. I have very strong nightly erections, high androgen levels and my estrogen is balanced as well. I do not really suffer from ED but my erections are not very good at times and take a long time to get going. I also have mild premature ejaculation, it is difficult for me to get erections going and when I do it's too easy for me to finish.

I think it has to do with overactive sympathetic since I easily stress and have some mild degree of social anxiety.

I tried Cypro before and it definitely makes me feel "normal" nervous system wise, normalizes stress. But even at 0.5mg it really wipes me out and makes me very unproductive and unmotivated. I could not keep taking it because my work suffers.

I've been recommended Agomelatine by Joe over at Selfhacked.com that I should try to decrease my 5-HT2C receptors since I seem to have genetics that upregulate these, have not tried it though. Is this relevant? I know they are serotonin receptors.

Peat said that even low dose vitamin B6 or low dose chemicals like Benadryl, cypro, or doxylamine have been known to help with premature ejaculation by regulating the (para)sympathetic tone.
 

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If erectile response to VES is not completely androgen dependent, then what are the most critical elements needed to cause such erectile response and spontaneous erections? Dopamine?

That would be my guess, and also enough CO2 since that is the preferred vasodilator in a state of good health. NO is only used in emergency situations.
 

ddjd

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A few agents that inhibit TGF-Beta are Taurine, Zinc, Milk Thistle, Emodin, Olive Oil, Vitamin D, Ginger, anything that is dopaminergic/anti-serotonin as 5-HT2 increases TGF-Beta, CO2 as hypoxia increases it, anti-estrogenic substances and probably any decalcifying agents like Magnesium and K2. Liver damage increases TGF-Beta. Avoiding cigarette smoke oxidation, endotoxins, excess alcohol, stress
I couldn't find any studies on zinc, milk thistle, Emodin etc. Where did you read about this
 

Aleeri

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That would be my guess, and also enough CO2 since that is the preferred vasodilator in a state of good health. NO is only used in emergency situations.

I have some lower COMT enzyme genetics making me run especially high on dopamine, I have crazy focus all the time such as easily able to spend 10-12 hours stretch sessions doing research or work without breaks no problem. I am hypersensitive to COMT inhibitors such as green tea. Too much social stimulus tend to overstimulate me (more dopamine) etc.

The thing is that having lots of Dopamine has not given me spontaneously, high-quality erections or an especially high libido, all forms of dopamine boosters I've tried such as L-Dopa, Ginseng, Caffeine, Theanine, Cistanche, Catuaba, Muira Puama, Shilajit, Amphetamine, Ritalin doesn't have any effect in this regard for me. Amphetamine makes me sick.

The only thing that had any slight effect from above would be maybe Coffee but it did not improve erections, only small libido increase.

Also strange enough Tongkat Ali quite strongly improves both my erection hardness, libido and mild PME, although it causes side effects of aggression, restlessness and insomnia.
I also have to use much lower dosage than recommended. But even before using Tongkat Ali I have top range Total T, mid-range bioavailable T and Free T, normal estrogen levels, so however it does this it does not seem to be hormone related.

I am at a complete loss why the classic testosterone or dopamine does not influence my sexual function at all, this is practically what everybody writes about online concerning male sexual function.

Is it really so simple that it is an overactive sympathetic nervous system thing? Lack of GABA?

I've tried Theanine, Glycine, GABA, megadose Camomille, they did not help.

What about CO2, what are the signs of low CO2? I lift weights twice a week and also practice Kendo twice a week, so I definitely don't feel like I have a blood flow problem, and neither do I feel like I am overtraining.
 

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