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Lapodin - Dietary Supplement With Beta-lapachone And Emodin

Discussion in 'IdeaLabs' started by haidut, Jan 29, 2016.

  1. dd99

    dd99 Member

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    Thanks for the new product. Am I right in thinking Lapodin would be effective against colds and flu, the way Oxidal is, but without the potential MAO effects?
     
  2. OP
    haidut

    haidut Member

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    The links I posted on both substances have an entire section on the antiinflammatory properties and mechanisms. If you go through these it would be very informative. At a high level, both cascara and lapacho extracts inhibit the COX and LOX enzymes, iNOS, estrogen, and prolactin.
    As far as absorption, I get the same effects on temperature from a single topical dose that I get from 3 daily doses taken morning/noon/evening. Not sure what that means for absorption but I think it is much higher topically than orally. Also, both quinones are known to be poorly absorbed orally and this is the reason behind the laxative effects of emodin.
     
  3. OP
    haidut

    haidut Member

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    Yes, that's what the research indicates. But I think it would be even more effective when combined with Oxidal or other methylene blue products.
     
  4. OP
    haidut

    haidut Member

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    The more direct studies I have seen on this were with taurine, since taurine is also both anti-fibrotic and also improves digestion, which is compromised in people with cystic fibrosis. That being said, both emodin and beta lapachone have some of the same mechanisms of action and have reversed fibrosis of the heart/liver in studies. So, they should help. Other powerful anti-fibrotic substances are theanine, glycine, and caffeine.
     
  5. OP
    haidut

    haidut Member

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    It's not the combo per se but the topical application that should reduce the laxative effect. The laxative effects is due mainly do the poor absorbability of the anthraquinones so that they are able to reach the colon and exert anti-inflammatory effect mostly there. However, their systemic effect also contributes and with topical application it should be primarily the systemic effect that manifests itself.
     
  6. OP
    haidut

    haidut Member

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    A very high quality cascara bark usually has about 8% emodin by weight and very high quality lapacho bark is usually about 4% beta lapachone.
     
  7. Cheesecake

    Cheesecake Member

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    So @haidut to clarify, if a person was using cascara primarily FOR its laxative effects (if bowel movements were infrequent) then would Lapodin still be helpful in this regard? Or do you think taking cascara (or any laxative-producing substance) for this reason is not to be encouraged?
     
  8. OP
    haidut

    haidut Member

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    Lapodin would still be helpful due to the higher doses of emodin it provides than what one would ingest from typical cascara supplement even in multi-gram doses per day. So, even taken topically it should have a colon-shrinking effect if the colon if inflamed and absorbing too much water but the effects would be more systemic than local colonic effect.
     
  9. Cheesecake

    Cheesecake Member

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    Ok great to know. Thanks
     
  10. allblues

    allblues Member

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    Feedback time;
    I've had some heavy cortisol/adrenaline going for a few days after a very stressful event, muscles weak, heart pounding, feeling my pulse where i normally dont (back of my hands, and elsewhere), relaxation impossible.
    Tried to kill it with salt, sugar, etc, but nothing could make me calm down.
    For some reason didnt try Lapodin until today - but boy am i glad i did!

    10 min after applying 3-4 drops on each forearm my body is relaxing. Heartbeat is settling down, pulse no longer thumping all over. Thank god.

    I've also had the same calming effect before from a few drops of Kuinone topically.

    Thank you @haidut for a seriously helpful product :)
     
  11. OP
    haidut

    haidut Member

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    Awesome! Thank you for sharing.
     
  12. honeybee

    honeybee Member

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    Feedback: 1 week of using topically-ramping up from 5, 10 to 24 drops per day (24 is the suggested dosage). Now taking 15 drops am and 5-10drops pm.

    Very relaxed feeling within 10-20 minutes-greatly improved dropping off to sleep and staying asleep. Plus plus -so this is helping with stress hormones (cortisol perhaps adrenalin)

    I'm using in combination with 2 drops (from a 1 ounce diluted) methylene blue in the am to assist with estrogen and prolactin reduction. I noticed immediate (next day and ongoing daily) improvement with these dominance symptoms. This is what I originally purchased it for and Im very happy with these results.

    When I use it after b-fast, it kills my appetite for lunch and seems to suppress it throughout the rest of the day-this was unexpected. Im not sure why this is happening.

    Increase in # of bowel movements but nothing drastic or extreme.

    The only issue I have (and its not a big deal but worth a mention) is that the little bottle seems to clog with some of the dark material near the tip. If I'm not careful it will clog and then suddenly unclog and gets all over the place. Shaking the bottle helps a bit but I've had to use a sterilized needle tip to push the matter down into the bottle and then shake.
    This is a very dark colored product-dark brown-but it does not stain the skin. The brown color absorbs completely into skin within a couple of minutes.

    Overall very pleased with this product. I'll report back. Unless it stops working, I want to keep using it for the effective reduction of estrogen and prolactin symptoms.
     
  13. Kasper

    Kasper Member

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    Anyone that used this some kind of mouth wash?

    I was wondering if that could be a use case, as emodin seems to help with caries.
     
  14. OP
    haidut

    haidut Member

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    Perfect, thanks for the feedback! The sediment issue should be resolved in the latest batch as we started filtering the liquid before pouring into the bottles. May I ask then you bought your Lapodin?
     
  15. honeybee

    honeybee Member

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    @haidut I bought it no more than 2-3 weeks ago.
     
  16. OP
    haidut

    haidut Member

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    OK, let me look into that. I just checked the current batch and I don't see any large particle sediment in it. I can send you a replacement bottle if you'd like.
     
  17. honeybee

    honeybee Member

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    @haidut thank you I think I'm fine with my bottle. I just thought it worth a mention and a little warning to others To avoid accidental spills/waste of product and potential staining.
    Your offer does say a lot about you standing behind your products and increases my estimation of and trust in your brand. I appreciate that.
     
  18. postman

    postman Member

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    Is there a maximum safe dose? First time I took it I accidentally took 40 drops and I felt a more beneficial effect
     
  19. OP
    haidut

    haidut Member

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    I don't know that there is a maximum beneficial dose but in higher doses it may think the blood, as both emodin and beta-lapachone have this effect. It is probably due to the estrogen antagonism. So, some vitamin K may be warranted with higher doses, but I don't know how much and in what ratio to the emodin/lapachone. The dose in Lapodin is based on things Peat has written about emodin an Cascara in the past and an email I exchanged with him on beta-lapachone. Taking 2-3 doses daily may give you doses similar to the ones with animals for diabetes, cortisol, cancer, dementia, etc. But it is those higher doses that may need extra vitamin K.
     
  20. DaveFoster

    DaveFoster Member

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    Just placed an order for Lapodin. Looking forward to trying your product, and I'll make a log and report any benefits.
     
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