shepherdgirl

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@managing
AFAIK cascara is not adsorbent and can help metabolism via quinones. However, if taken orally, cascara can have a laxative effect. That is why i would try not to take it with meds or supps. Sorry to hijack this thread!
 

Spokey

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I'm not sure if this is Lanosterol, or the fact I've been hitting the thyroid a bit more regularly, but...

A few years ago I was in a car accident and had some whiplash. I got most of the function of my neck and shoulders back, but I never managed to get entirely pain free or fluid movement there. Recently these areas started really hurting but also freeing up. The frozen shoulder I experienced has become a lot looser and more mobile, I'm more aware of the position of my neck, which when I move I can hear the crinkling of synovial garbage that's been there for quite some time. A lot of the discomfort is gone. I'm aware that hypothyroidism is associated with a lot of joint issues, but I've taken thyroid before and not got these results, so I think it's at least in part the lanosterol.

Is anyone else experiencing changes in joint mobility from this stuff?
 

aarfai

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I'm not sure if this is Lanosterol, or the fact I've been hitting the thyroid a bit more regularly, but...

A few years ago I was in a car accident and had some whiplash. I got most of the function of my neck and shoulders back, but I never managed to get entirely pain free or fluid movement there. Recently these areas started really hurting but also freeing up. The frozen shoulder I experienced has become a lot looser and more mobile, I'm more aware of the position of my neck, which when I move I can hear the crinkling of synovial garbage that's been there for quite some time. A lot of the discomfort is gone. I'm aware that hypothyroidism is associated with a lot of joint issues, but I've taken thyroid before and not got these results, so I think it's at least in part the lanosterol.

Is anyone else experiencing changes in joint mobility from this stuff?
How much Lanosterol and thyroid are you taking?
 

Spokey

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10mg lanosterol, and between two and three drops of tyromix with my morning and evening meals.
 

BrianF

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I guess most people on the forum who have heard of lanosterol know it in the context of treating cataracts.
Lanosterol - Wikipedia

There is a company out there who used to sell lanosterol as eye drops and it is insanely expensive - $100 for a meager 10mg lanosterol.
Anyways, lanosterol is actually a very interesting molecule in its own right and its benefits go way beyond eye health, even though the mechanism of action for cataracts suggests where else it may be beneficial. The primary effect of lanosterol are related to reversing protein aggregation in the eyes and in brain (ALS, Alzheimer, Huntington, CTE, TBI), protecting dopamiergic neurons (Parkinson), inhibiting cortisol synthesis, uncoupling metabolism, protecting from viral (flu) and bacterial (tetanus) infections, anti-endotoxin (TLR4), and has been studied as a cancer prevention chemical. There is some preliminary research that lanosterol may retard and even reverse lipofuscin accumulation but the evidence on that is still very sparse. Most of the studies found that the optimal concentration of lanosterol is in the range 5uM - 10uM for most experiments, except for Huntington disease where 1uM was enough.
If the protein aggregation in the brain can indeed be reversed then lanosterol can be very interesting for the NFL community, military and other professions where TBI/CTE is common.
So, in light of these interesting properties of lanosterol I decided to release it as a supplement.


The units listed on the label are just for measurement purposes. They do not indicate suggested or optimal dose. Please note that similar to the products sold by companies like BluePeptides, this product is for lab/research use only. The product can be ordered from the link below:
www.idealabsdc.com/lab

*******************************************************************************
Lanosterol is the primary precursor of cholesterol (and thus steroids) of animals and fungi. It has been shown to possess a number of beneficial health effects including reversing protein aggregation in neurodegenerative diseases, pro-metabolic (uncoupler), anti-inflammatory, anti-endotoxin, anti-glucocorticoid, anti-viral, anti-mutagenic, antimicrobial, anti-cancer, anxiolytic, antidepressant, and generally anti-aging.


Drops per container: about 240
Each drop contains the following ingredients:

Lanosterol: 1mg

Other ingredients: tocopherols, MCT
*******************************************************************************

References:


Neurodegenerative conditions
Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases. - PubMed - NCBI
"...Accumulation of misfolded or aberrant proteins in neuronal cells is linked with neurodegeneration and other pathologies. Which molecular mechanisms fail and cause inappropriate folding of proteins and what is their relationship to cellular toxicity is not well known. How does it happen and what are the probable therapeutic or molecular approaches to counter them are also not clear. Here, we demonstrate that treatment of lanosterol diminishes aberrant proteotoxic aggregation and mitigates their cytotoxicity via induced expression of co-chaperone CHIP and elevated autophagy. The addition of lanosterol not only reduces aggregation of mutant bonafide misfolded proteins but also effectively prevents accumulation of various mutant disease-prone proteotoxic proteins. Finally, we observed that lanosterol mitigates cytotoxicity in cells, mediated by different stress-inducing agents. Taken together, our present results suggest that upregulation of cellular molecular chaperones, primarily using small molecules, can probably offer an efficient therapeutic approach in the future against misfolding of different disease-causing proteins and neurodegenerative disorders."

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington's disease. - PubMed - NCBI
Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. - PubMed - NCBI

Eye health
Lanosterol reverses protein aggregation in cataracts. - PubMed - NCBI

Anti-glucocorticoid (11b-HSD1 inhibitor)
Endogenous inhibitors of 11 beta-OHSD: existence and possible significance. - PubMed - NCBI

Endotoxin protection
Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages. - PubMed - NCBI

Fertility
Effect of lanosterol on the in vitro maturation in semi-defined culture system of prepubertal ewe oocytes. - PubMed - NCBI
Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos. - PubMed - NCBI
Effects of lanosterol on in vitro maturation of porcine oocytes. - PubMed - NCBI
Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial follicle pool in mouse fetal ovary. - PubMed - NCBI

Metabolism/uncoupling
Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. - PubMed - NCBI
"...As expected, treatment of neurons with 200 nM m-chlorophenylhydrazone (CCCP), a known uncoupler of oxidative phosphorylation, induced an immediate and sharp reduction of the mitochondrial membrane potential (∼25% within 30 s; Figure 6a). Under these same experimental conditions, exogenous addition of lanosterol reduced the membrane potential by ∼20% over 15 min, whereas PC and cholesterol had no significant effect (Figure 6b)."

Antimicrobial, antiparasitic, antiviral
Influenza viral membrane fusion is sensitive to sterol concentration but surprisingly robust to sterol chemical identity. - PubMed - NCBI
[Effect of the administration of lanosterol on the rat exposed to an injection of tetanus toxin]. - PubMed - NCBI
[Attenuation of the effects of tetanus toxin in mice after absorption of lanosterol]. - PubMed - NCBI
[Decrease of mortality in the rat after administration of lanosterol during an epidemic bronchopulmonary infection]. - PubMed - NCBI

Anti-proliferative
Influence of lanosterol and chicken embryonal extract upon the course of 3,4-benzpyrene induced skin carcinogenesis in mice. - PubMed - NCBI
Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis. - PubMed - NCBI

Pro-dopamine
Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. - PubMed - NCBI

So something that reversed protein aggregation in neurodegenerative diseases could possibly be good news for people who suffer from Alzheimer's or some other type of dementia related conditions - theoretically speaking of course - on a purely theoretical basis you understand?
 
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haidut

haidut

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So something that reversed protein aggregation in neurodegenerative diseases could possibly be good news for people who suffer from Alzheimer's or some other type of dementia related conditions - theoretically speaking of course - on a purely theoretical basis you understand?

I mentioned this in the very post you quoted. Look at the 5th line from the top.
 

managing

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Seems like this thread has stalled out. I just started trying this out. Want to wait until I have more experience before I respond on that.

What dosage (and how) are people using?
 
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haidut

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Seems like this thread has stalled out. I just started trying this out. Want to wait until I have more experience before I respond on that.

What dosage (and how) are people using?

Most people who reported using lanosterol seem to be sticking to the 5mg - 8mg amount daily. It seems to have a sedating and thermogenic effects on those amounts.
 

managing

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Most people who reported using lanosterol seem to be sticking to the 5mg - 8mg amount daily. It seems to have a sedating and thermogenic effects on those amounts.
I'm ready for at least a preliminary report.

I started with one drop at night. I liked that, so I added a drop in the morning. I found that it was mildly sedating in the morning. Not groggy, just that feeling of needing a cup of coffee.

So I started 2 drops at night. I liked that. So I switched to 3 drops at night. I am liking that but will stick with it for a week or so before I up it again.

So, what do I like? I have to say, I haven't seen any thermogenic effects. I am going to bed shortly afterwards and it has been colder at night. So maybe I sleep through it.

Or, maybe like thyroid, if it lowers cortisol, while having other thermogenic qualities, you can still get a net reduction in temp. I haven't had labs, but I would have to say anecdotally that it has had a significant impact on cortisol. I'm feeling colder. While many on here strive to feel warmer, I strive to feel colder (appropriate to climate). Along with that has come calmer, clearer headed, more energy, more endurance. I would also say quite clearly symptoms of higher T (voice, muscle, sexual). That may be secondary to reduced cortisol rather than a primary effect. So don't know if others are going to see that or not.

Ongoing experiment. If I get to 5mg or experience anything else interesting, I'll let you know.

@haidut would you say this is the strongest anti-cortisol of your products?
 
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haidut

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I'm ready for at least a preliminary report.

I started with one drop at night. I liked that, so I added a drop in the morning. I found that it was mildly sedating in the morning. Not groggy, just that feeling of needing a cup of coffee.

So I started 2 drops at night. I liked that. So I switched to 3 drops at night. I am liking that but will stick with it for a week or so before I up it again.

So, what do I like? I have to say, I haven't seen any thermogenic effects. I am going to bed shortly afterwards and it has been colder at night. So maybe I sleep through it.

Or, maybe like thyroid, if it lowers cortisol, while having other thermogenic qualities, you can still get a net reduction in temp. I haven't had labs, but I would have to say anecdotally that it has had a significant impact on cortisol. I'm feeling colder. While many on here strive to feel warmer, I strive to feel colder (appropriate to climate). Along with that has come calmer, clearer headed, more energy, more endurance. I would also say quite clearly symptoms of higher T (voice, muscle, sexual). That may be secondary to reduced cortisol rather than a primary effect. So don't know if others are going to see that or not.

Ongoing experiment. If I get to 5mg or experience anything else interesting, I'll let you know.

@haidut would you say this is the strongest anti-cortisol of your products?

Nope, not the strongest. I think Lapodin, Progestene, Cyproheptadine and Diamant would be up there.
Thanks for the feedback though! Some people reported nootropic effect. Let me know if you notice improved memory, cognition and creativity.
 

managing

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Nope, not the strongest. I think Lapodin, Progestene, Cyproheptadine and Diamant would be up there.
Thanks for the feedback though! Some people reported nootropic effect. Let me know if you notice improved memory, cognition and creativity.
Most definitely. "Calmer, clearer headed, more energy" are partly my way of experiencing nootropic effects. Creativity is pretty subjective, but I have found that I have renewed enthusiasm for my work and am trying to solve problems that weren't stimulating me to act before.
 

johnsmith

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Subject got a bad concussion one year ago and still has post concussion symptoms, so thought this product was made for him.

Took 5 drops around eye and temple, and 4 drops orally. Noticed what seemed to be a lifting of brain fog within 12 minutes. Temperature went up .4 degrees, and felt slightly sleepy off and on. Also there was a cessation of anger and racing thoughts, felt more connected to his environment. He had second thoughts of his recent visual art expressions of hatred and thought they might be hurtful. This is not normal.

Subject has been writing reviews for Idealabs products for the past half hour, and has now been on substance for over an hour. Seems to have good focus, writing product reviews normally isn't a common activity for subject, lol.
 

managing

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Subject got a bad concussion one year ago and still has post concussion symptoms, so thought this product was made for him.

Took 5 drops around eye and temple, and 4 drops orally. Noticed what seemed to be a lifting of brain fog within 12 minutes. Temperature went up .4 degrees, and felt slightly sleepy off and on. Also there was a cessation of anger and racing thoughts, felt more connected to his environment. He had second thoughts of his recent visual art expressions of hatred and thought they might be hurtful. This is not normal.

Subject has been writing reviews for Idealabs products for the past half hour, and has now been on substance for over an hour. Seems to have good focus, writing product reviews normally isn't a common activity for subject, lol.
Good for you!

I will caution that 9 drops is a large dose. Just alerting you to keep awareness of side effects. I have no clue if its too large or not.

It definitely has a mild sedative effect for me too. Not in a "knock you out" kind of way. Just in a "I'm ready to go to bed and sleep nicely for 8 hours" kind of way. I'm finding that taking once/day (bedtime) is just fine for me with no noticeable curtailment of benefits 23.5 hrs later.
 

managing

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Transdermal. Contrary to @aarfai I would say it has significantly enhanced my sleep.

I am now on 4 drops. I can't tell whether I like 4 better than 3 yet. Only weird thing I've seen is shortly after applying to my forearms, I'll get tingling and a muscle spasm somewhere on that arm. It only last for a few minutes.
 

managing

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Is there anything about Lanosterol that would enhance thyroid production? Since I started applying, I've been getting an "overstimulated" feeling from Thyroid (Tyromix) sometimes.
 
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haidut

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Is there anything about Lanosterol that would enhance thyroid production? Since I started applying, I've been getting an "overstimulated" feeling from Thyroid (Tyromix) sometimes.

It is an uncoupler of metabolism, as mentioned in the original thread. Thyroid is also an uncoupler. So, combined they may have even stronger effects and raise pulse, temp to an uncomfortable level. So, maybe best to use separately or use lower doses when used together. The latter should be a good thing as bottles would last longer and risk of side effects is lower with smaller doses.
 
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