Lamotrigine Improves ADHD Symptoms

DaveFoster

Member
Joined
Jul 23, 2015
Messages
5,027
Location
Portland, Oregon
The drug lamotrigine lowers glutamate in the brain and can treat seizures, bipolar depression, OCD and certain personality disorders including BPD. This study underscores the role of excess glutamate in a wide range of neurological disorders including ADHD:

"The mean ADHD test score of the 90 subjects was 17.0±1.8 at baseline. It was slightly reduced to 15.6±1.7 after lamotrigine monotherapy (P >0.01). Prior to treatment, a total of 31 patients (34.4%) met the diagnostic criteria for ADHD according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision, Of these 31 patients, 27 (87.1%) had significantly improved ADHD scores with lamotrigine monotherapy (28.0±1.6 reduced to 18.1±2.6, P<0.001). Among these 27 patients, 25 (92.6%) showed normalized electroencephalogram (EEG) and 26 (96.3%) achieved total freedom from seizures within 12 months of the initiation of lamotrigine monotherapy."

SOURCE: Effects of lamotrigine on attention-deficit hyperactivity disorder in pediatric epilepsy patients

Originally posted at the Foster Your Health blog: Lamotrigine Improves ADHD Symptoms
 
Last edited:

Daniil

Member
Joined
Feb 13, 2021
Messages
870
Location
Moscow
interestingly that caffeine is effective for ADHD, but it is pro-glutamate

 

Frankdee20

Member
Joined
Jul 13, 2017
Messages
3,772
Location
Sun Coast, USA
A lot of people think attention problems come from low dopamine, but guarantee you that someone with low GABA and high Glutamate will do horrible on Amphetamine or Ritalin... You have to have a balance between GABA and the excitatory neurotransmitters, otherwise your attention will be very rigid, and you can’t shift focus
 

No_Energy

Member
Joined
Dec 16, 2017
Messages
241
How's it going @DaveFoster? Have you had the chance to test it?.
Usually used for Bipolar, but it seems to have many uses - off label, including depression. Anyone else on the forum with experience with Lamotrigine that they could share? effects, side effects..
 

Frankdee20

Member
Joined
Jul 13, 2017
Messages
3,772
Location
Sun Coast, USA
How's it going @DaveFoster? Have you had the chance to test it?.
Usually used for Bipolar, but it seems to have many uses - off label, including depression. Anyone else on the forum with experience with Lamotrigine that they could share? effects, side effects..
It has been linked to Steven’s Johnson syndrome
 

Similar threads

Back
Top Bottom