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Lamotrigine Improves ADHD Symptoms

Discussion in 'Pharmaceutical Drugs' started by DaveFoster, Jan 14, 2018.

  1. DaveFoster

    DaveFoster Member

    Joined:
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    The drug lamotrigine lowers glutamate in the brain and can treat seizures, bipolar depression, OCD and certain personality disorders including BPD. This study underscores the role of excess glutamate in a wide range of neurological disorders including ADHD:

    "The mean ADHD test score of the 90 subjects was 17.0±1.8 at baseline. It was slightly reduced to 15.6±1.7 after lamotrigine monotherapy (P >0.01). Prior to treatment, a total of 31 patients (34.4%) met the diagnostic criteria for ADHD according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision, Of these 31 patients, 27 (87.1%) had significantly improved ADHD scores with lamotrigine monotherapy (28.0±1.6 reduced to 18.1±2.6, P<0.001). Among these 27 patients, 25 (92.6%) showed normalized electroencephalogram (EEG) and 26 (96.3%) achieved total freedom from seizures within 12 months of the initiation of lamotrigine monotherapy."

    SOURCE: Effects of lamotrigine on attention-deficit hyperactivity disorder in pediatric epilepsy patients

    Originally posted at the Foster Your Health blog: Lamotrigine Improves ADHD Symptoms
     
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