Lamotrigine Improves ADHD Symptoms

Discussion in 'Pharmaceutical Drugs' started by DaveFoster, Jan 14, 2018 at 1:51 AM.

  1. DaveFoster

    DaveFoster Member

    Jul 23, 2015
    The drug lamotrigine lowers glutamate in the brain and can treat seizures, bipolar depression, OCD and certain personality disorders including BPD. This study underscores the role of excess glutamate in a wide range of neurological disorders including ADHD:

    "The mean ADHD test score of the 90 subjects was 17.0±1.8 at baseline. It was slightly reduced to 15.6±1.7 after lamotrigine monotherapy (P >0.01). Prior to treatment, a total of 31 patients (34.4%) met the diagnostic criteria for ADHD according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision, Of these 31 patients, 27 (87.1%) had significantly improved ADHD scores with lamotrigine monotherapy (28.0±1.6 reduced to 18.1±2.6, P<0.001). Among these 27 patients, 25 (92.6%) showed normalized electroencephalogram (EEG) and 26 (96.3%) achieved total freedom from seizures within 12 months of the initiation of lamotrigine monotherapy."

    SOURCE: Effects of lamotrigine on attention-deficit hyperactivity disorder in pediatric epilepsy patients

    Originally posted at the Foster Your Health blog: Lamotrigine Improves ADHD Symptoms