Lactic Acid as a Stroke Protectant

[ysdj]

Lactate Supply from Astrocytes to Neurons and its Role in Ischemic Stroke-induced Neurodegeneration

• Lactate in the brain is involved in nerve function and nerve cell survival.
• Stroke stimulation induces MCT4 expression and enhances lactate production.
• Lactate production from astrocytes may contribute to stroke prevention.

Brain Protection after Anoxic Brain Injury: Is Lactate Supplementation Helpful?

...Indeed, lactate does not require adenosine triphosphate (ATP) to be oxidated and it could therefore serve as an alternative substrate in condition of depleted energy reserves, i.e., reperfusion injury, even in presence of adequate tissue oxygen delivery. Lactate enriched solutions were studied in recent years in healthy subjects, acute heart failure, and severe traumatic brain injured patients, showing possible benefits that extend beyond the role as alternative energetic substrates.

Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia

We concluded that intra-ischemically-accumulated lactate is utilized aerobically as the main energy substrate immediately postischemia. Blockade of lactate transport into neurons prevents its utilization and, consequently, exacerbates delayed ischemic neuronal damage.

Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain

Exogenous supplemental lactate can be utilized aerobically as a preferential energy substrate by the injured human brain, with sparing of cerebral glucose. Increased availability of cerebral extracellular pyruvate and glucose, coupled with a reduction of brain glutamate and ICP, suggests that hypertonic lactate therapy has beneficial cerebral metabolic and hemodynamic effects after TBI.

 

[mostlylurking]

Lactate Supply from Astrocytes to Neurons and its Role in Ischemic Stroke-induced Neurodegeneration



Brain Protection after Anoxic Brain Injury: Is Lactate Supplementation Helpful?



Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia



Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain

Difference Between Lactate and Lactic Acid | Compare the Difference Between Similar Terms

Lactate vs Lactic Acid Lactic acid and lactate are conjugate acid and base of each other. Chemically, their difference is in having and not having hy

www.differencebetween.com

 

[ysdj]

Difference Between Lactate and Lactic Acid | Compare the Difference Between Similar Terms

Lactate vs Lactic Acid Lactic acid and lactate are conjugate acid and base of each other. Chemically, their difference is in having and not having hy

www.differencebetween.com

Lactic acid does not usually exist alone, so lactic acid usually refers to lactate here.

 

[mostlylurking]

Lactic acid does not usually exist alone, so lactic acid usually refers to lactate here.

This thread is extolling the virtues of Lactic Acid in its title, Lactic Acid As A Stroke Protectant. Having nearly died from lactic acidosis and knowing how dangerous lactic acid is I thought it might be a good idea to point out that lactate and lactic acid are NOT one and the same.