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L-Carnitine Is Anti-thyroid

Discussion in 'Scientific Studies' started by haidut, Apr 16, 2014.

  1. OP
    haidut

    haidut Member

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    I prefer the NAC route too. Also, based on the studies I posted and their follow up once the glutathione was replenished in the elderly patients it remained high until they had an illness episode of some kind. So, it seems that you only need to do this once to replenish it and then it should last for a while. I did the full 2 weeks course as described in the study.
    For people who do not want to take isolated aminos - egg whites have both glycine and cysteine in large amounts. So drinking a 16oz container of egg whites a day can achieve about the same (a carton of liquid pasteurized egg whites that I can buy from Safeway, Whole Foods, or Harris Teeter is equivalent to about 12 eggs). Costs about $4 a carton, so drinking one a day for 2 weeks is affordable for most people.
     
  2. Javelina

    Javelina Member

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    [/quote]

    Low glutathione is pretty easily replenished by taking 10g of glycine and 10g of NAC for about 2 weeks. Here is the study:

    http://www.ncbi.nlm.nih.gov/pubmed/21795440

    [/quote]

    I looked at the study and they didn't say anything about using NAC, they used straight up cysteiene. I don't know if that's significantly different. Also FWIW, the stuff was administered intravenously, not orally.
     
  3. OP
    haidut

    haidut Member

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    Low glutathione is pretty easily replenished by taking 10g of glycine and 10g of NAC for about 2 weeks. Here is the study:

    http://www.ncbi.nlm.nih.gov/pubmed/21795440

    [/quote]

    I looked at the study and they didn't say anything about using NAC, they used straight up cysteiene. I don't know if that's significantly different. Also FWIW, the stuff was administered intravenously, not orally.[/quote]

    Javelina, I am not sure what study you are looking at but the study I posted has this language in the section "Metabolic study protocol":

    "...Only the elderly subjects received oral treatment of 14 d with 0.81 mmol cysteine · kg−1 · d−1 (as n-acetylcysteine) and 1.33 mmol glycine · kg−1 · d−1 after which they were restudied."

    So, the administration was indeed oral (not IV) and they used NAC. Am I missing something??

    Also, if you convert the mols to mg you will get a dosage of 100mg/kg of bodyweight for each amino acid. This translates to about 10g of each amino acid for a human weighing 100kg. Most humans would weigh less, but to compensate for inefficiency of absorption in oral administration and to make it simpler for people I just said 10g of each amino acid as that should have an effect on almost everyone.
     
  4. Such_Saturation

    Such_Saturation Member

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    Can't hype anything more than fish oil :mrgreen:
     
  5. NathanK

    NathanK Member

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    1. Thanks for the laughs for whomever called paleo darling carnitine thyroid kryptonite.

    2. I'm no scientist, but I think this study shows that if you were to supplement cysteine (They didn't use NAC) then lower dosage may be more effective or you could be primarily converting to sulphate. Does that sound right?

    http://www.ncbi.nlm.nih.gov/pubmed/1542000

    J Nutr. 1992 Mar;122(3):420-7.
    Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes.

    "...Low cysteine availability favored its utilization for glutathione; high cysteine availability favored its catabolism to sulfate and taurine. Under conditions of low cysteine availability (incubations with 0.2 mmol/L OTC), glutathione, sulfate and taurine production accounted for 90, 10 and 1%, respectively, of total metabolism. Under conditions of high cysteine availability (incubations with 1 mmol/L cysteine + bathocuproine disulfonate), glutathione, sulfate and taurine production accounted for 19, 47 and 34%, respectively, of total metabolism. Cysteine supplied as such and cysteine formed intracellularly from methionine were similarly partitioned. These studies demonstrate that methionine is not a superior substrate to cysteine for hepatic glutathione synthesis and that cysteine concentration (presumably intracellular cysteine concentration) has a major effect on the partitioning of cysteine sulfur to taurine in rat hepatocytes."
     
  6. sugarbabe

    sugarbabe Member

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    This reminds me of a supp I used to take called zinc l carnosine to supposedly heal gut lining. Is it similar to carnitine?
     
  7. aarfai

    aarfai Member

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  8. OP
    haidut

    haidut Member

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    No, that supplement is a complex of zinc and the amino acid l-carnosine. Casnorine is itself a complex of beta alanine and histidine, and is not related to carnitine except that both of them are found in meat. Zinc carnosine is a legit supplement for things like ulcers and dyspepsia. In Japan it is a prescription drug.
     
  9. Such_Saturation

    Such_Saturation Member

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    Where I live they give L-Acetylcarnitine for nerve issues :confused
     
  10. OP
    haidut

    haidut Member

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    Interesting, considering it can easily cause seizures in overexcited people.
     
  11. Such_Saturation

    Such_Saturation Member

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    That's probably what they consider a working nerve :ss
     
  12. johnwester130

    johnwester130 Member

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    It's incredibly anti metabolic

    although I have read lysine converts into carnitine

    "Coconut oil is unusually rich in short and medium chain fatty acids. Shorter chain length allows fatty acids to be metabolized without use of the carnitine transport system. Mildronate, which I discussed in an article on adaptogens, protects cells against stress partly by opposing the action of carnitine, and comparative studies showed that added carnitine had the opposite effect, promoting the oxidation of unsaturated fats during stress, and increasing oxidative damage to cells. I suspect that a degree of saturation of the oxidative apparatus by short-chain fatty acids has a similar effect--that is, that these very soluble and mobile short-chain saturated fats have priority for oxidation, because they don't require carnitine transport into the mitochondrion, and that this will tend to inhibit oxidation of the unstable, peroxidizable unsaturated fatty acids. "
     
  13. Thyroidhelp

    Thyroidhelp New Member

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    Hi Guys,

    I am one of those hashimotos (hypo) people who fell for the acetyl la carnitine benefits of extra energy, and I would like to know if there is a way to reduce carnitine in the body?

    It gave me heart palps, heart stopping for a couple of seconds, severe hypoglycemia, dizziness, severe fatigue, muscle weakness, twitching etc.

    Any help appreciated :)
     
  14. YuraCZ

    YuraCZ Member

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    "deficiencies can be caused by consuming raw egg whites over a period of months to years. Egg whites contain high levels of avidin, a protein that binds biotin strongly. When cooked, avidin is partially denatured and binding to biotin is reduced. However one study showed that 30-40% of the avidin activity was still present in the white after frying or boiling.[1] Hence excessive cooked egg white consumption could possibly cause biotin deficiency."
     
  15. OP
    haidut

    haidut Member

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  16. milk_lover

    milk_lover Member

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    According to this study (http://www.ncbi.nlm.nih.gov/pubmed/12493087), "excess dietary lysine depressed muscle creatinine concentration, but only in the presence of the lower concentrations of arginine and methionine." So does this mean lysine could possibly increase both triiodothyronine (T3) and thyroxine (T4) entry into the cell nuclei by depressing creatinine?
    The same study said, "as expected, kidney arginase activity increased as dietary lysine increased." Does this mean lysine is increasing arginase/arginine degradation by the kidney? How will that affect amonia?
     
  17. paymanz

    paymanz Member

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    Maybe those very ill patient are insulin resistant,due to FFA for example,and then carnitin at least help them beta oxidize better and make some energy.for short term they benefit...


    I wondering if it help to clean up blood from FFAs then at some point it can improve insulin sensitivity?

    This carnitin and good result with mildronate,also some studies show good result from carnitin supplement ,all of these are confusing.

    But for sure I would not try oral carnitin supplement(due to fermentation),probably never try other routes either!
     
  18. tankasnowgod

    tankasnowgod Member

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    Just a random thought on Carnitine supplementation......

    Most L-Carnitine sold is Carnitine Taurate or Carnipure, meaning it is bound with Taurine. Looking at Now brand L-Carnitine, 1 g of Carnitine comes from 1470mg of Carnitine Taurate. Soooo, is it possible the benefits people really see from Carnitine Supplementation are from Taurine? There are reported GI side effects at higher doses, and I know from personal experience that Taurine can cause the same sort of GI sides. Any thoughts? @haidut
     
  19. OP
    haidut

    haidut Member

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    It's definitely possible. Carnitine can also increase cortisol synthesis and initially that can make people feel quite good. Since it also excites the brain, that can also feel like a pick me up but in the long run people pay the price. There is no reason to use carnitine as supplement. Whatever needs people have can be easily met through food.
     
  20. catharsis

    catharsis New Member

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