L-carnitine In Red Meat: Bad?

Discussion in 'Articles & Scientific Studies' started by jyb, Apr 8, 2013.

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  1. jyb

    jyb Member

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  2. Giraffe

    Giraffe Member

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    Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

    "Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstrate here that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice. Omnivorous human subjects produced more TMAO than did vegans or vegetarians following ingestion of l-carnitine through a microbiota-dependent mechanism. The presence of specific bacterial taxa in human feces was associated with both plasma TMAO concentration and dietary status. Plasma l-carnitine levels in subjects undergoing cardiac evaluation (n = 2,595) predicted increased risks for both prevalent cardiovascular disease (CVD) and incident major adverse cardiac events (myocardial infarction, stroke or death), but only among subjects with concurrently high TMAO levels. Chronic dietary l-carnitine supplementation in mice altered cecal microbial composition, markedly enhanced synthesis of TMA and TMAO, and increased atherosclerosis, but this did not occur if intestinal microbiota was concurrently suppressed. In mice with an intact intestinal microbiota, dietary supplementation with TMAO or either carnitine or choline reduced in vivo reverse cholesterol transport. Intestinal microbiota may thus contribute to the well-established link between high levels of red meat consumption and CVD risk."
     
  3. treelady

    treelady Member

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    We keep a bottle of l-carnitine on hand to melt away those aches and pains after heavy labor. (Prob from lactic acid buildup.)
     
  4. Agent207

    Agent207 Member

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    I think Acetyl-L-Carnitine is much better. Maybe there be some trade-off, since almost nothing is absolutely good/bad. Even if the side of alcar is to promote fatty acid liberation, there are other aspects, as its benefit on the skin helping with lipofuscin removal. For a lean person who doesn't tend to accumulate much fat I don't see a problem either.

    Context is everything.
     
  5. paymanz

    paymanz Member

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    carnitine suppresses sugar metabolism, all white meats including sea foods contain much less canitine than red meat.also on good thing about goat milk is its low carnitine levels.

    Meldonium , is the drug i really like try it but its expensive and also not easily available.i dont know if there is any cheaper substitute for it?as effective?
     
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