Kuinone - Liquid Vitamin K2 (MK-4)

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haidut

haidut

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I experience the same reaction.
Positives are : I got an productive kind of energy the first day. Another good thing is I look leaner and my skin looks super good. Libido is also up.
All after 2 days .
But i also experience bad mood ,irritable ,anxious ,depressed ,out of breath and sneezing often after I take Kuinone. If its irritating the gut those could be symptoms of high serotonin ?! But even taken topically it reaches the gut after some time , in a less concentrated way of course so I dont really know what to do . Would love to be able to take it .

Vitamin K can raise CO2 and that can lead to feeling of being out of breath. It can also raise GABA and that can have paradoxical effects such as irritability and bad mood, similar to allopregnanolone (a potent GABA agonist).
Allopregnanolone - Wikipedia
"...Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety, irritability, and aggression.[29][30][31] This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABAA receptor – moderate level increases (in the range of 1.5–2 nM/L total allopregnanolone, which are approximately equivalent to luteal phase levels) inhibit the activity of the receptor, while lower and higher concentration increases stimulate it.[29][30] This seems to be a common effect of many GABAAreceptor positive allosteric modulators.[26][31] In accordance, acute administration of low doses of micronized progesterone (which reliably elevates allopregnanolone levels) has been found to have negative effects on mood, while higher doses have a neutral effect.[32]"
 

Mauritio

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Vitamin K can raise CO2 and that can lead to feeling of being out of breath. It can also raise GABA and that can have paradoxical effects such as irritability and bad mood, similar to allopregnanolone (a potent GABA agonist).
Allopregnanolone - Wikipedia
"...Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety, irritability, and aggression.[29][30][31] This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABAA receptor – moderate level increases (in the range of 1.5–2 nM/L total allopregnanolone, which are approximately equivalent to luteal phase levels) inhibit the activity of the receptor, while lower and higher concentration increases stimulate it.[29][30] This seems to be a common effect of many GABAAreceptor positive allosteric modulators.[26][31] In accordance, acute administration of low doses of micronized progesterone (which reliably elevates allopregnanolone levels) has been found to have negative effects on mood, while higher doses have a neutral effect.[32]"
I never had a bad reaction to GABA , Phenibut (which is GABA that crosses the BBB) or 5adhp which ,as you know , gets converted mainly to allopregnenlone...
 

Arrade

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I never had a bad reaction to GABA , Phenibut (which is GABA that crosses the BBB) or 5adhp which ,as you know , gets converted mainly to allopregnenlone...
Could you be experiencing too low estrogen from the vitamin K?
I think that could lead to irritability and loss of empathy
 

Mauritio

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Could you be experiencing too low estrogen from the vitamin K?
I think that could lead to irritability and loss of empathy
Yeah i think along those lines... Either what you said or maybe if it detoxes estrogen faster than my liver can handle it creates a stress response ? Another reason to take it with Energin ,which is what I am going to do:
Switch to lower doses of K2 , up my oral Energin intake and take K2 only topically.
 

Miguel

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@haidut Here are the updated links that show the titles
Bone Health
Treatment of glucocorticoid-induced low bone mineral density in children: a systematic review. - PubMed - NCBI
Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. - PubMed - NCBI
Vitamin K2 improves femoral bone strength without altering bone mineral density in gastrectomized rats. - PubMed - NCBI
Vitamin K₂ therapy for postmenopausal osteoporosis. - PubMed - NCBI
Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. - PubMed - NCBI
Menatetrenone versus alfacalcidol in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, do... - PubMed - NCBI
Effects of vitamin K in postmenopausal women: mini review. - PubMed - NCBI
Menatetrenone for the treatment of osteoporosis. - PubMed - NCBI
Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone. - PubMed - NCBI
Amelioration of pregnancy-associated osteoporosis after treatment with vitamin K₂: a report of four patients. - PubMed - NCBI
Clinical results of alendronate monotherapy and combined therapy with menatetrenone (VitK₂) in postmenopausal RA patients. - PubMed - NCBI
Bridging the gap between osteoporosis and osteonecrosis of the jaw: preventing and treating BRONJ with MK4. - PubMed - NCBI
Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral de... - PubMed - NCBI
The prevention of hip fracture with menatetrenone and risedronate plus calcium supplementation in elderly patients with Alzheimer disease: a random... - PubMed - NCBI
Effect of vitamin K2 on cortical and cancellous bone mass and hepatic lipids in rats with combined methionine-choline deficiency. - PubMed - NCBI
Effect of GGCX gene polymorphism on the responses of serum undercarboxylated osteocalcin and bone turnover markers after treatment with vitamin K2 ... - PubMed - NCBI
Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats. - PubMed - NCBI
Vitamin K₂ alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level. - PubMed - NCBI
Effects of vitamin K2 on cortical and cancellous bone mass, cortical osteocyte and lacunar system, and porosity in sciatic neurectomized rats. - PubMed - NCBI
Vitamin K2 promotes bone healing in a rat femoral osteotomy model with or without glucocorticoid treatment. - PubMed - NCBI
Effects of combination treatment with alendronate and vitamin K(2) on bone mineral density and strength in ovariectomized mice. - PubMed - NCBI
Prevention of hip fractures by exposure to sunlight and pharmacotherapy in patients with Alzheimer's disease. - PubMed - NCBI
Vitamin K to prevent fractures in older women: systematic review and economic evaluation. - PubMed - NCBI
Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -indep... - PubMed - NCBI
Efficacy of menatetrenone (vitamin K2) against non-vertebral and hip fractures in patients with neurological diseases: meta-analysis of three rando... - PubMed - NCBI
Comparison of the effect of vitamin K(2) and risedronate on trabecular bone in glucocorticoid-treated rats: a bone histomorphometry study. - PubMed - NCBI
Collagen-related abnormalities, reduction in bone quality, and effects of menatetrenone in rats with a congenital ascorbic acid deficiency. - PubMed - NCBI
Prior treatment with vitamin K(2) significantly improves the efficacy of risedronate. - PubMed - NCBI
Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover in postmenopausal osteoporo... - PubMed - NCBI
Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North Am... - PubMed - NCBI
Randomized controlled study on the prevention of osteoporotic fractures (OF study): a phase IV clinical study of 15-mg menatetrenone capsules. - PubMed - NCBI
Vitamin K2, a gamma-carboxylating factor of gla-proteins, normalizes the bone crystal nucleation impaired by Mg-insufficiency. - PubMed - NCBI
[Treatment of primary osteoporosis with vitamin K2]. - PubMed - NCBI
[Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function]. - PubMed - NCBI
Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. - PubMed - NCBI
Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene. - PubMed - NCBI
Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. - PubMed - NCBI
Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis. - PubMed - NCBI
Beneficial effect of pretreatment and treatment continuation with risedronate and vitamin K2 on cancellous bone loss after ovariectomy in rats: a b... - PubMed - NCBI
Infrared analysis of bones in magnesium-deficient rats treated with vitamin K2. - PubMed - NCBI
[Active vitamin D and vitamin K as therapeutic agents for osteoporosis]. - PubMed - NCBI
[Diabetic osteopahty and vitamin K]. - PubMed - NCBI
[Therapeutic approaches for diabetic osteopahty]. - PubMed - NCBI
Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia. - PubMed - NCBI
Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats. - PubMed - NCBI
Comparative effects of vitamin K and vitamin D supplementation on calcium balance in young rats fed normal or low calcium diets. - PubMed - NCBI
[The interplay of magnesium and vitamin K2 on bone mineralization]. - PubMed - NCBI
[Vitamin K2 and bone quality]. - PubMed - NCBI
[Vitamin K2 (menatetrenone) and bone quality]. - PubMed - NCBI
Effects of vitamin K2 administration on calcium balance and bone mass in young rats fed normal or low calcium diet. - PubMed - NCBI
Menatetrenone rescues bone loss by improving osteoblast dysfunction in rats immobilized by sciatic neurectomy. - PubMed - NCBI
Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). - PubMed - NCBI
Effects of vitamin K2 (menatetrenone) and alendronate on bone mineral density and bone strength in rats fed a low-magnesium diet. - PubMed - NCBI
Histochemical evaluation for the biological effect of menatetrenone on metaphyseal trabeculae of ovariectomized rats. - PubMed - NCBI
Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels. - PubMed - NCBI
Vitamin K2 and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner. - PubMed - NCBI
Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. - PubMed - NCBI
Menatetrenone ameliorates reduction in bone mineral density and bone strength in sciatic neurectomized rats. - PubMed - NCBI
Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. - PubMed - NCBI
Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors. - PubMed - NCBI
High serum levels of menatetrenone in male patients with ossification of the posterior longitudinal ligament. - PubMed - NCBI
Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa. - PubMed - NCBI
Effect of vitamin K2 on cortical and cancellous bones in orchidectomized and/or sciatic neurectomized rats. - PubMed - NCBI
Vitamin K stimulates osteoblastogenesis and inhibits osteoclastogenesis in human bone marrow cell culture. - PubMed - NCBI
Effect of vitamin K2 on cortical and cancellous bones in orchidectomized young rats. - PubMed - NCBI
Pharmacodynamics of menatetrenone and effects on bone metabolism in continuous ambulatory peritoneal dialysis patients. - PubMed - NCBI
Vitamin K2 (menatetrenone) inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats. - PubMed - NCBI
Menatetrenone prevents osteoblast dysfunction in unilateral sciatic neurectomized rats. - PubMed - NCBI
[Effect of menatetrenone (V.K2) on bone mineral density and bone strength in Ca/Mg deficient rats]. - PubMed - NCBI
Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal women. - PubMed - NCBI
Maintenance of trabecular structure and bone volume by vitamin K(2) in mature rats with long-term tail suspension. - PubMed - NCBI
Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. - PubMed - NCBI
A comparison of alfacalcidol and menatetrenone for the treatment of bone loss in an ovariectomized rat model of osteoporosis. - PubMed - NCBI
Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver. - PubMed - NCBI
Effects of phenytoin and/or vitamin K2 (menatetrenone) on bone mineral density in the tibiae of growing rats. - PubMed - NCBI
Effects of vitamin K2 (menatetrenone) on calcium balance in ovariectomized rats. - PubMed - NCBI
Efficacy and safety of Menatetrenone-4 postmenopausal Thai women. - PubMed - NCBI
Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency. - PubMed - NCBI
Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: a comparison with t... - PubMed - NCBI
Effects of vitamin K on calcium and bone metabolism. - PubMed - NCBI
Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) tre... - PubMed - NCBI
Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis. - PubMed - NCBI
[Effects of vitamin K2 administration in the patients with severely motor and intellectual disabilities: assessment of bone metabolic marker and bo... - PubMed - NCBI
Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures. - PubMed - NCBI
Effect of vitamin K2 on three-dimensional trabecular microarchitecture in ovariectomized rats. - PubMed - NCBI
Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. - PubMed - NCBI
Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis. - PubMed - NCBI
Menatetrenone plus alfacalcidol treatment for bone problems in eight children with skeletal unloading. - PubMed - NCBI
[Vitamin K2 (menatetrenone) treatment increased bone strength in rats given low-calcium diets]. - PubMed - NCBI
Inhibitory effect of vitamin K2 (menatetrenone) on bone resorption in ovariectomized rats: a histomorphometric and dual energy X-ray absorptiometri... - PubMed - NCBI
Use of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolide. - PubMed - NCBI
A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-p... - PubMed - NCBI
[Effects of a vitamin K2 preparation in severely handicapped patients complicated by osteopenia]. - PubMed - NCBI
Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients. - PubMed - NCBI
Vitamin K2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro. - PubMed - NCBI
Vitamin K2 promotes 1alpha,25(OH)2 vitamin D3-induced mineralization in human periosteal osteoblasts. - PubMed - NCBI
The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain. - PubMed - NCBI
Effect of vitamin K2 (menatetrenone) on osteoclast-like cell formation in mouse bone marrow cultures. - PubMed - NCBI
[Influence of vitamin D3 on inhibitory effect of vitamin K2 on bone loss in ovariectomized rats]. - PubMed - NCBI
Effects of menatetrenone on the decrease in calcium balance induced by vitamin K-deficient diet and sodium loading in rats. - PubMed - NCBI
Effects of menatetrenone on prednisolone-induced bone loss in rats. - PubMed - NCBI
Effects of menatetrenone on bone loss induced by ovariectomy in rats. - PubMed - NCBI
Vitamin K2 modulates proliferation and function of osteoblastic cells in vitro. - PubMed - NCBI
 
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Miguel

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@haidut
Cardiovascular disease (CVD)
Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease. - PubMed - NCBI
Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. - PubMed - NCBI
Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. - PubMed - NCBI
Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. - PubMed - NCBI
Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. - PubMed - NCBI

Diabetes
Vitamin K₂ prevents hyperglycemia and cancellous osteopenia in rats with streptozotocin-induced type 1 diabetes. - PubMed - NCBI
Antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice. - PubMed - NCBI

Kidney Health
Vitamin K(2) improves renal function and increases femoral bone strength in rats with renal insufficiency. - PubMed - NCBI

Cancer
Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controll... - PubMed - NCBI
Role of vitamin K2 in preventing the recurrence of hepatocellular carcinoma after curative treatment: a meta-analysis of randomized controlled trials. - PubMed - NCBI
Chemoprevention of chemically-induced biliary carcinogenesis in hamsters by vitamin K2. - PubMed - NCBI
Effect of vitamin K2 on the development of hepatocellular carcinoma in type C cirrhosis. - PubMed - NCBI
Soluble VEGF receptor-2 may be a predictive marker of anti-angiogenic therapy with clinically available safe agents. - PubMed - NCBI
Vitamin analogues in chemoprevention of hepatocellular carcinoma after resection or ablation--a systematic review and meta-analysis. - PubMed - NCBI
Vitamin K2 augments 5-fluorouracil-induced growth inhibition of human hepatocellular carcinoma cells by inhibiting NF-κB activation. - PubMed - NCBI
Multicenter phase II trial of vitamin K(2) monotherapy and vitamin K(2) plus 1alpha-hydroxyvitamin D(3) combination therapy for low-risk myelodyspl... - PubMed - NCBI
Inhibition of matrix metalloproteinase expression by menatetrenone, a vitamin K2 analogue. - PubMed - NCBI
Vitamin K2 suppresses proliferation and motility of hepatocellular carcinoma cells by activating steroid and xenobiotic receptor. - PubMed - NCBI
Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma. - PubMed - NCBI
Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma. - PubMed - NCBI
Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nucle... - PubMed - NCBI
Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments. - PubMed - NCBI
Preventive effects of vitamin K on recurrent disease in patients with hepatocellular carcinoma arising from hepatitis C viral infection. - PubMed - NCBI
The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treat... - PubMed - NCBI
[Vitamin K2 therapy for myelodysplastic syndrome]. - PubMed - NCBI
Menatetrenone, a vitamin K2 analog, ameliorates cytopenia in patients with refractory anemia of myelodysplastic syndrome. - PubMed - NCBI
Vitamin K2 therapy for myelodysplastic syndromes (MDS) and post-MDS acute myeloid leukemia: information through a questionnaire survey of multi-cen... - PubMed - NCBI
Successful therapy of myelodysplastic syndrome with menatetrenone, a vitamin K2 analog. - PubMed - NCBI
Vitamin K2 combined with all-trans retinoic acid induced complete remission of relapsing acute promyelocytic leukaemia. - PubMed - NCBI
Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid. - PubMed - NCBI
https://www.glowm.com/pdf/Book-OvarianCancerTherapeutics-CC-BY-Ch13.pdf


Neurological Health
Vitamin K and brain function. - PubMed - NCBI
Vitamin K: a structural basis for the design of novel neuroprotective agents? - PubMed - NCBI
Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides. - PubMed - NCBI
Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes. - PubMed - NCBI
Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain. - PubMed - NCBI

Testosterone
Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. - PubMed - NCBI
Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis. - PubMed - NCBI

Estrogen
Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism. - PubMed - NCBI
 
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haidut

haidut

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@haidut
Cardiovascular disease (CVD)
Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease. - PubMed - NCBI
Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. - PubMed - NCBI
Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. - PubMed - NCBI
Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. - PubMed - NCBI
Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. - PubMed - NCBI

Diabetes
Vitamin K₂ prevents hyperglycemia and cancellous osteopenia in rats with streptozotocin-induced type 1 diabetes. - PubMed - NCBI
Antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice. - PubMed - NCBI

Kidney Health
Vitamin K(2) improves renal function and increases femoral bone strength in rats with renal insufficiency. - PubMed - NCBI

Cancer
Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controll... - PubMed - NCBI
Role of vitamin K2 in preventing the recurrence of hepatocellular carcinoma after curative treatment: a meta-analysis of randomized controlled trials. - PubMed - NCBI
Chemoprevention of chemically-induced biliary carcinogenesis in hamsters by vitamin K2. - PubMed - NCBI
Effect of vitamin K2 on the development of hepatocellular carcinoma in type C cirrhosis. - PubMed - NCBI
Soluble VEGF receptor-2 may be a predictive marker of anti-angiogenic therapy with clinically available safe agents. - PubMed - NCBI
Vitamin analogues in chemoprevention of hepatocellular carcinoma after resection or ablation--a systematic review and meta-analysis. - PubMed - NCBI
Vitamin K2 augments 5-fluorouracil-induced growth inhibition of human hepatocellular carcinoma cells by inhibiting NF-κB activation. - PubMed - NCBI
Multicenter phase II trial of vitamin K(2) monotherapy and vitamin K(2) plus 1alpha-hydroxyvitamin D(3) combination therapy for low-risk myelodyspl... - PubMed - NCBI
Inhibition of matrix metalloproteinase expression by menatetrenone, a vitamin K2 analogue. - PubMed - NCBI
Vitamin K2 suppresses proliferation and motility of hepatocellular carcinoma cells by activating steroid and xenobiotic receptor. - PubMed - NCBI
Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma. - PubMed - NCBI
Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma. - PubMed - NCBI
Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nucle... - PubMed - NCBI
Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments. - PubMed - NCBI
Preventive effects of vitamin K on recurrent disease in patients with hepatocellular carcinoma arising from hepatitis C viral infection. - PubMed - NCBI
The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treat... - PubMed - NCBI
[Vitamin K2 therapy for myelodysplastic syndrome]. - PubMed - NCBI
Menatetrenone, a vitamin K2 analog, ameliorates cytopenia in patients with refractory anemia of myelodysplastic syndrome. - PubMed - NCBI
Vitamin K2 therapy for myelodysplastic syndromes (MDS) and post-MDS acute myeloid leukemia: information through a questionnaire survey of multi-cen... - PubMed - NCBI
Successful therapy of myelodysplastic syndrome with menatetrenone, a vitamin K2 analog. - PubMed - NCBI
Vitamin K2 combined with all-trans retinoic acid induced complete remission of relapsing acute promyelocytic leukaemia. - PubMed - NCBI
Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid. - PubMed - NCBI
https://www.glowm.com/pdf/Book-OvarianCancerTherapeutics-CC-BY-Ch13.pdf


Neurological Health
Vitamin K and brain function. - PubMed - NCBI
Vitamin K: a structural basis for the design of novel neuroprotective agents? - PubMed - NCBI
Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides. - PubMed - NCBI
Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes. - PubMed - NCBI
Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain. - PubMed - NCBI

Testosterone
Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. - PubMed - NCBI
Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis. - PubMed - NCBI

Estrogen
Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism. - PubMed - NCBI

Great, thank you.
 
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Mauritio

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That


Great, thank you.
I dont know what you mean. But i have to tell you today i took 2x2 drops of Kuinone on scrotum and i felt super good! I guess it was the Energin that caused anxiety , i think thats more likely as I was able to reproduce the symptoms after not haven taken it for the whole day.
 
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haidut

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I dont know what you mean. But i have to tell you today i took 2x2 drops of Kuinone on scrotum and i felt super good! I guess it was the Energin that caused anxiety , i think thats more likely as I was able to reproduce the symptoms after not haven taken it for the whole day.

Sorry, the forum software automatically include a partial quote in my response to you. I edited my original post.
Glad to hear Kuinone is having this effect. It seems to be pretty consistent across most males who tried it.
 
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haidut

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it seems the new kuinone is using fema 2415 too now.

It is an add-on, not the only solvent. Only 1 batch, because we wanted to see if it increases transdermal absorption.
 
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haidut

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How are you measuring the degree to which it is/isn’t?

No way to measure this directly as there does not seem to be a blood test for MK-4. But there are a studies with other chemical like steroids and antihistamine showing ~30% increased absorption when FEMA 2415 is added compared to when just ethanol is used.
 

Muckl3

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Can this be used 1-2 times a week rather than everyday, like d3 can be dosed less. If so what dose would be good for 1-2 times a week just for general health?
 
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Can this be used 1-2 times a week rather than everyday, like d3 can be dosed less. If so what dose would be good for 1-2 times a week just for general health?

Peat said he used vitamin K once weekly. I think he takes 5mg-10mg once weekly together with 50,000 IU D3. Human studies show that as little as 0.9mg daily is enough for stimulation of bone anabolism, so I guess 6mg-7mg weekly sounds about right, matching what Peat is doing.
 

caliwom

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Peat said he used vitamin K once weekly. I think he takes 5mg-10mg once weekly together with 50,000 IU D3. Human studies show that as little as 0.9mg daily is enough for stimulation of bone anabolism, so I guess 6mg-7mg weekly sounds about right, matching what Peat is doing.


@haidut Does Peat take those amounts of D and K topically or orally?
 
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yerrag

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The other day I woke up to a lower blood pressure of 150/89, a large drop which I did not expect. The night before, I went to bed 196/125.

I took repeated measurements to make sure it wasn't instrument or human error.

I had been on a week of all fruits, and I broke the fruit fast the night before by eating a large slab of ribeye. For that week, the fruits were watermelon, melon, pineapple, papaya, and bananas. I was also taking the ff. supplements per day:

Niacinamide - 3 x 700 mg
Aspirin - 2 x 325 mg
B-Complex tablet - 1
Vitamin C powder - 4 x 1700mg
Baking Soda - 4 x 1000 mg (checking my urine pH to ensure I don't exceed safe levels)
Mag Glycinate - 3 x 133 mg elemental magnesium
Calcium Acetate - 2 x 500 mg elemental Ca
NAC - 1 x 600 mg
Selenomethionine - 1 x 200 mcg
Vitamin D - 1 x 5000 IU

The day before my blood pressure dropped, I also started to use:

2 x 2 drops of Tyromix (12 mcg T3; 24 mcg T4)
2 x 2 drops of StressNon (7 mg)
2 x 2 drops of Progestene (7 mg)
1 x 4 drops of TocoVit vitamin E (120 IU)
1 x 1 drop of Kuinone (1.5 mg)

That same day, I also lay down on a far infrared mat set to a high setting for 2 hours.

Like all things in life that are too good to be true, the lower blood pressure was only a fleeting precious moment. I'm now back to previous high blood pressure levels, even as I maintained the protocol.

What do you think made the biggest difference among the supplements/treatments? What triggered the lower blood pressure? Was there a mechanism where ACE was inhibited and therefore caused vasodilation that relaxed my blood vessels?

Some more information: LDH is slightly above range at 220, but my hsCRP and ESR readings are normal, hsCRP at 0.8 and ESR at 0. LDH was the only inflammatory marker that tests positive, which in itself doesn't conform to usual situations. My serum albumin is at 42 ( range 38 -47) and my urine has a slightly high level of albumin, which would be classified as CKD (chronic kidney disease) stage 1, although barely.

I suspect that because I have never taken hypertensive medication, it has enabled the body to produce uric acid at higher levels to counter ROS production by neutrophils (as neutrophils phagocytize periodontal bacteria from a hidden gum problem (recently resolved)). This has minimized the tissue destruction to a level that registers as LDH slightly above range, but the inflammatory burden is significantly reduced as evidenced by low hsCRP and ESR readings.

Since I believe the source of infection has been resolved, as evidenced by lowered neutrophils readings in my CBC, my high blood pressure reflects a certain inertia in place, where some blood vessels have forgotten to relax or dilate due to my long years of being in a hypertensive state (15+ years).

What I need now is to use some supplements to coax my blood vessels (in the kidneys) to relax.

In this regard, how much daily Vitamin K2 should I need? I seem to recall Ray Peat mentioning its use at a certain dosage but I can't find the information.
 

yerrag

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The other day I woke up to a lower blood pressure of 150/89, a large drop which I did not expect. The night before, I went to bed 196/125.

I took repeated measurements to make sure it wasn't instrument or human error.

I had been on a week of all fruits, and I broke the fruit fast the night before by eating a large slab of ribeye. For that week, the fruits were watermelon, melon, pineapple, papaya, and bananas. I was also taking the ff. supplements per day:

Niacinamide - 3 x 700 mg
Aspirin - 2 x 325 mg
B-Complex tablet - 1
Vitamin C powder - 4 x 1700mg
Baking Soda - 4 x 1000 mg (checking my urine pH to ensure I don't exceed safe levels)
Mag Glycinate - 3 x 133 mg elemental magnesium
Calcium Acetate - 2 x 500 mg elemental Ca
NAC - 1 x 600 mg
Selenomethionine - 1 x 200 mcg
Vitamin D - 1 x 5000 IU

The day before my blood pressure dropped, I also started to use:

2 x 2 drops of Tyromix (12 mcg T3; 24 mcg T4)
2 x 2 drops of StressNon (7 mg)
2 x 2 drops of Progestene (7 mg)
1 x 4 drops of TocoVit vitamin E (120 IU)
1 x 1 drop of Kuinone (1.5 mg)

That same day, I also lay down on a far infrared mat set to a high setting for 2 hours.

Like all things in life that are too good to be true, the lower blood pressure was only a fleeting precious moment. I'm now back to previous high blood pressure levels, even as I maintained the protocol.

What do you think made the biggest difference among the supplements/treatments? What triggered the lower blood pressure? Was there a mechanism where ACE was inhibited and therefore caused vasodilation that relaxed my blood vessels?

Some more information: LDH is slightly above range at 220, but my hsCRP and ESR readings are normal, hsCRP at 0.8 and ESR at 0. LDH was the only inflammatory marker that tests positive, which in itself doesn't conform to usual situations. My serum albumin is at 42 ( range 38 -47) and my urine has a slightly high level of albumin, which would be classified as CKD (chronic kidney disease) stage 1, although barely.

I suspect that because I have never taken hypertensive medication, it has enabled the body to produce uric acid at higher levels to counter ROS production by neutrophils (as neutrophils phagocytize periodontal bacteria from a hidden gum problem (recently resolved)). This has minimized the tissue destruction to a level that registers as LDH slightly above range, but the inflammatory burden is significantly reduced as evidenced by low hsCRP and ESR readings.

Since I believe the source of infection has been resolved, as evidenced by lowered neutrophils readings in my CBC, my high blood pressure reflects a certain inertia in place, where some blood vessels have forgotten to relax or dilate due to my long years of being in a hypertensive state (15+ years).

What I need now is to use some supplements to coax my blood vessels (in the kidneys) to relax.

In this regard, how much daily Vitamin K2 should I need? I seem to recall Ray Peat mentioning its use at a certain dosage but I can't find the information.

I think I'll go with 15 mg k2/day :

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yerrag

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I think I'll go with 15 mg k2/day :

Search
I rubbed 5 drops of Kuinone this afternoon, equiv to 7;5 mg of k2. Then had 1 hour of far infrared therapy on a mat that warms up with infrared heat.

Before : 195/117 blood pressure

After: 155/102 (3 hours later)

About a year ago, k2 didn't work for me. There was something else going on inside me that needed to be resolved before the effects of k2 could kick in. Since then, I had built up my body's electrolyte levels. Recently, a hidden periodontal condition was discovered and the condition was resolved. The chronic bacterial infection was a source of stress that likely contributed to the high blood pressure. My neutrophil levels, after years of steadily increasing from 54% to 74%, finally began to come down and at the last test, it went down to 64%. This somehow confirms that the chronic bacterial infection is gone, and that there's less need for neutrophils.

What seems to remain are the blood vessels (not sure if it's the renal artery or just the glomerular capillaries) in my kidneys used to 15 years of high blood pressure and probably becoming thick and inflexible. Vitamin K2 looks to be working to restore the suppleness of the blood vessels.

I also had benefited from therapeutic intakes of niacinamide, taken at a dose of 30 mg/kg. I'm not sure if the infrared mat helped, but I think it did.

I don't want to jump the gun yet. Much work remains to be done but I am hopeful that this chapter of battling high blood pressure will be the last.
 
EMF Mitigation - Flush Niacin - Big 5 Minerals

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