1. **NEW Mini Body Light** MBL1 - Orange & Red Light Therapy Mini Body Light
    CLICK HERE!
    Dismiss Notice
  2. Cholesterol Powder
    CLICK HERE!
    Dismiss Notice
  3. Pau D'arco Bark
    CLICK HERE!
    Dismiss Notice
  4. Metabasoap - Handcrafted Soap
    CLICK HERE!
    Dismiss Notice
  5. Cocoa Butter - Organic & Fair Trade Certified
    CLICK HERE!
    Dismiss Notice
  6. Charcoal Soap - For Deep Cleansing
    CLICK HERE!
    Dismiss Notice
  7. Orange & Red Light Therapy Device - LGS1
    CLICK HERE!
    Dismiss Notice
  8. Cascara Sagrada Powder From Farmalabor In Italy
    CLICK HERE!
    Dismiss Notice

Kuinone - Liquid Vitamin K2 (MK-4)

Discussion in 'IdeaLabs' started by haidut, Jan 11, 2016.

  1. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    14,487
    Gender:
    Male
    Location:
    USA / Europe
    Vitamin K can raise CO2 and that can lead to feeling of being out of breath. It can also raise GABA and that can have paradoxical effects such as irritability and bad mood, similar to allopregnanolone (a potent GABA agonist).
    Allopregnanolone - Wikipedia
    "...Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety, irritability, and aggression.[29][30][31] This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABAA receptor – moderate level increases (in the range of 1.5–2 nM/L total allopregnanolone, which are approximately equivalent to luteal phase levels) inhibit the activity of the receptor, while lower and higher concentration increases stimulate it.[29][30] This seems to be a common effect of many GABAAreceptor positive allosteric modulators.[26][31] In accordance, acute administration of low doses of micronized progesterone (which reliably elevates allopregnanolone levels) has been found to have negative effects on mood, while higher doses have a neutral effect.[32]"
     
  2. Mauritio

    Mauritio Member

    Joined:
    Feb 26, 2018
    Messages:
    296
    Gender:
    Male
    I never had a bad reaction to GABA , Phenibut (which is GABA that crosses the BBB) or 5adhp which ,as you know , gets converted mainly to allopregnenlone...
     
  3. Arrade

    Arrade Member

    Joined:
    Apr 29, 2018
    Messages:
    1,496
    Gender:
    Male
    Could you be experiencing too low estrogen from the vitamin K?
    I think that could lead to irritability and loss of empathy
     
  4. Mauritio

    Mauritio Member

    Joined:
    Feb 26, 2018
    Messages:
    296
    Gender:
    Male
    Yeah i think along those lines... Either what you said or maybe if it detoxes estrogen faster than my liver can handle it creates a stress response ? Another reason to take it with Energin ,which is what I am going to do:
    Switch to lower doses of K2 , up my oral Energin intake and take K2 only topically.
     
  5. Miguel

    Miguel Member

    Joined:
    Dec 29, 2013
    Messages:
    20
    @haidut Here are the updated links that show the titles
    Bone Health
    Treatment of glucocorticoid-induced low bone mineral density in children: a systematic review. - PubMed - NCBI
    Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. - PubMed - NCBI
    Vitamin K2 improves femoral bone strength without altering bone mineral density in gastrectomized rats. - PubMed - NCBI
    Vitamin K₂ therapy for postmenopausal osteoporosis. - PubMed - NCBI
    Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. - PubMed - NCBI
    Menatetrenone versus alfacalcidol in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, do... - PubMed - NCBI
    Effects of vitamin K in postmenopausal women: mini review. - PubMed - NCBI
    Menatetrenone for the treatment of osteoporosis. - PubMed - NCBI
    Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone. - PubMed - NCBI
    Amelioration of pregnancy-associated osteoporosis after treatment with vitamin K₂: a report of four patients. - PubMed - NCBI
    Clinical results of alendronate monotherapy and combined therapy with menatetrenone (VitK₂) in postmenopausal RA patients. - PubMed - NCBI
    Bridging the gap between osteoporosis and osteonecrosis of the jaw: preventing and treating BRONJ with MK4. - PubMed - NCBI
    Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral de... - PubMed - NCBI
    The prevention of hip fracture with menatetrenone and risedronate plus calcium supplementation in elderly patients with Alzheimer disease: a random... - PubMed - NCBI
    Effect of vitamin K2 on cortical and cancellous bone mass and hepatic lipids in rats with combined methionine-choline deficiency. - PubMed - NCBI
    Effect of GGCX gene polymorphism on the responses of serum undercarboxylated osteocalcin and bone turnover markers after treatment with vitamin K2 ... - PubMed - NCBI
    Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats. - PubMed - NCBI
    Vitamin K₂ alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level. - PubMed - NCBI
    Effects of vitamin K2 on cortical and cancellous bone mass, cortical osteocyte and lacunar system, and porosity in sciatic neurectomized rats. - PubMed - NCBI
    Vitamin K2 promotes bone healing in a rat femoral osteotomy model with or without glucocorticoid treatment. - PubMed - NCBI
    Effects of combination treatment with alendronate and vitamin K(2) on bone mineral density and strength in ovariectomized mice. - PubMed - NCBI
    Prevention of hip fractures by exposure to sunlight and pharmacotherapy in patients with Alzheimer's disease. - PubMed - NCBI
    Vitamin K to prevent fractures in older women: systematic review and economic evaluation. - PubMed - NCBI
    Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -indep... - PubMed - NCBI
    Efficacy of menatetrenone (vitamin K2) against non-vertebral and hip fractures in patients with neurological diseases: meta-analysis of three rando... - PubMed - NCBI
    Comparison of the effect of vitamin K(2) and risedronate on trabecular bone in glucocorticoid-treated rats: a bone histomorphometry study. - PubMed - NCBI
    Collagen-related abnormalities, reduction in bone quality, and effects of menatetrenone in rats with a congenital ascorbic acid deficiency. - PubMed - NCBI
    Prior treatment with vitamin K(2) significantly improves the efficacy of risedronate. - PubMed - NCBI
    Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover in postmenopausal osteoporo... - PubMed - NCBI
    Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North Am... - PubMed - NCBI
    Randomized controlled study on the prevention of osteoporotic fractures (OF study): a phase IV clinical study of 15-mg menatetrenone capsules. - PubMed - NCBI
    Vitamin K2, a gamma-carboxylating factor of gla-proteins, normalizes the bone crystal nucleation impaired by Mg-insufficiency. - PubMed - NCBI
    [Treatment of primary osteoporosis with vitamin K2]. - PubMed - NCBI
    [Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function]. - PubMed - NCBI
    Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. - PubMed - NCBI
    Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene. - PubMed - NCBI
    Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. - PubMed - NCBI
    Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis. - PubMed - NCBI
    Beneficial effect of pretreatment and treatment continuation with risedronate and vitamin K2 on cancellous bone loss after ovariectomy in rats: a b... - PubMed - NCBI
    Infrared analysis of bones in magnesium-deficient rats treated with vitamin K2. - PubMed - NCBI
    [Active vitamin D and vitamin K as therapeutic agents for osteoporosis]. - PubMed - NCBI
    [Diabetic osteopahty and vitamin K]. - PubMed - NCBI
    [Therapeutic approaches for diabetic osteopahty]. - PubMed - NCBI
    Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia. - PubMed - NCBI
    Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats. - PubMed - NCBI
    Comparative effects of vitamin K and vitamin D supplementation on calcium balance in young rats fed normal or low calcium diets. - PubMed - NCBI
    [The interplay of magnesium and vitamin K2 on bone mineralization]. - PubMed - NCBI
    [Vitamin K2 and bone quality]. - PubMed - NCBI
    [Vitamin K2 (menatetrenone) and bone quality]. - PubMed - NCBI
    Effects of vitamin K2 administration on calcium balance and bone mass in young rats fed normal or low calcium diet. - PubMed - NCBI
    Menatetrenone rescues bone loss by improving osteoblast dysfunction in rats immobilized by sciatic neurectomy. - PubMed - NCBI
    Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). - PubMed - NCBI
    Effects of vitamin K2 (menatetrenone) and alendronate on bone mineral density and bone strength in rats fed a low-magnesium diet. - PubMed - NCBI
    Histochemical evaluation for the biological effect of menatetrenone on metaphyseal trabeculae of ovariectomized rats. - PubMed - NCBI
    Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels. - PubMed - NCBI
    Vitamin K2 and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner. - PubMed - NCBI
    Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. - PubMed - NCBI
    Menatetrenone ameliorates reduction in bone mineral density and bone strength in sciatic neurectomized rats. - PubMed - NCBI
    Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. - PubMed - NCBI
    Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors. - PubMed - NCBI
    High serum levels of menatetrenone in male patients with ossification of the posterior longitudinal ligament. - PubMed - NCBI
    Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa. - PubMed - NCBI
    Effect of vitamin K2 on cortical and cancellous bones in orchidectomized and/or sciatic neurectomized rats. - PubMed - NCBI
    Vitamin K stimulates osteoblastogenesis and inhibits osteoclastogenesis in human bone marrow cell culture. - PubMed - NCBI
    Effect of vitamin K2 on cortical and cancellous bones in orchidectomized young rats. - PubMed - NCBI
    Pharmacodynamics of menatetrenone and effects on bone metabolism in continuous ambulatory peritoneal dialysis patients. - PubMed - NCBI
    Vitamin K2 (menatetrenone) inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats. - PubMed - NCBI
    Menatetrenone prevents osteoblast dysfunction in unilateral sciatic neurectomized rats. - PubMed - NCBI
    [Effect of menatetrenone (V.K2) on bone mineral density and bone strength in Ca/Mg deficient rats]. - PubMed - NCBI
    Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal women. - PubMed - NCBI
    Maintenance of trabecular structure and bone volume by vitamin K(2) in mature rats with long-term tail suspension. - PubMed - NCBI
    Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. - PubMed - NCBI
    A comparison of alfacalcidol and menatetrenone for the treatment of bone loss in an ovariectomized rat model of osteoporosis. - PubMed - NCBI
    Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver. - PubMed - NCBI
    Effects of phenytoin and/or vitamin K2 (menatetrenone) on bone mineral density in the tibiae of growing rats. - PubMed - NCBI
    Effects of vitamin K2 (menatetrenone) on calcium balance in ovariectomized rats. - PubMed - NCBI
    Efficacy and safety of Menatetrenone-4 postmenopausal Thai women. - PubMed - NCBI
    Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency. - PubMed - NCBI
    Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: a comparison with t... - PubMed - NCBI
    Effects of vitamin K on calcium and bone metabolism. - PubMed - NCBI
    Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) tre... - PubMed - NCBI
    Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis. - PubMed - NCBI
    [Effects of vitamin K2 administration in the patients with severely motor and intellectual disabilities: assessment of bone metabolic marker and bo... - PubMed - NCBI
    Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures. - PubMed - NCBI
    Effect of vitamin K2 on three-dimensional trabecular microarchitecture in ovariectomized rats. - PubMed - NCBI
    Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. - PubMed - NCBI
    Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis. - PubMed - NCBI
    Menatetrenone plus alfacalcidol treatment for bone problems in eight children with skeletal unloading. - PubMed - NCBI
    [Vitamin K2 (menatetrenone) treatment increased bone strength in rats given low-calcium diets]. - PubMed - NCBI
    Inhibitory effect of vitamin K2 (menatetrenone) on bone resorption in ovariectomized rats: a histomorphometric and dual energy X-ray absorptiometri... - PubMed - NCBI
    Use of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolide. - PubMed - NCBI
    A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-p... - PubMed - NCBI
    [Effects of a vitamin K2 preparation in severely handicapped patients complicated by osteopenia]. - PubMed - NCBI
    Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients. - PubMed - NCBI
    Vitamin K2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro. - PubMed - NCBI
    Vitamin K2 promotes 1alpha,25(OH)2 vitamin D3-induced mineralization in human periosteal osteoblasts. - PubMed - NCBI
    The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain. - PubMed - NCBI
    Effect of vitamin K2 (menatetrenone) on osteoclast-like cell formation in mouse bone marrow cultures. - PubMed - NCBI
    [Influence of vitamin D3 on inhibitory effect of vitamin K2 on bone loss in ovariectomized rats]. - PubMed - NCBI
    Effects of menatetrenone on the decrease in calcium balance induced by vitamin K-deficient diet and sodium loading in rats. - PubMed - NCBI
    Effects of menatetrenone on prednisolone-induced bone loss in rats. - PubMed - NCBI
    Effects of menatetrenone on bone loss induced by ovariectomy in rats. - PubMed - NCBI
    Vitamin K2 modulates proliferation and function of osteoblastic cells in vitro. - PubMed - NCBI
     
  6. Miguel

    Miguel Member

    Joined:
    Dec 29, 2013
    Messages:
    20
    @haidut
    Cardiovascular disease (CVD)
    Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease. - PubMed - NCBI
    Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. - PubMed - NCBI
    Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. - PubMed - NCBI
    Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. - PubMed - NCBI
    Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. - PubMed - NCBI

    Diabetes
    Vitamin K₂ prevents hyperglycemia and cancellous osteopenia in rats with streptozotocin-induced type 1 diabetes. - PubMed - NCBI
    Antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice. - PubMed - NCBI

    Kidney Health
    Vitamin K(2) improves renal function and increases femoral bone strength in rats with renal insufficiency. - PubMed - NCBI

    Cancer
    Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controll... - PubMed - NCBI
    Role of vitamin K2 in preventing the recurrence of hepatocellular carcinoma after curative treatment: a meta-analysis of randomized controlled trials. - PubMed - NCBI
    Chemoprevention of chemically-induced biliary carcinogenesis in hamsters by vitamin K2. - PubMed - NCBI
    Effect of vitamin K2 on the development of hepatocellular carcinoma in type C cirrhosis. - PubMed - NCBI
    Soluble VEGF receptor-2 may be a predictive marker of anti-angiogenic therapy with clinically available safe agents. - PubMed - NCBI
    Vitamin analogues in chemoprevention of hepatocellular carcinoma after resection or ablation--a systematic review and meta-analysis. - PubMed - NCBI
    Vitamin K2 augments 5-fluorouracil-induced growth inhibition of human hepatocellular carcinoma cells by inhibiting NF-κB activation. - PubMed - NCBI
    Multicenter phase II trial of vitamin K(2) monotherapy and vitamin K(2) plus 1alpha-hydroxyvitamin D(3) combination therapy for low-risk myelodyspl... - PubMed - NCBI
    Inhibition of matrix metalloproteinase expression by menatetrenone, a vitamin K2 analogue. - PubMed - NCBI
    Vitamin K2 suppresses proliferation and motility of hepatocellular carcinoma cells by activating steroid and xenobiotic receptor. - PubMed - NCBI
    Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma. - PubMed - NCBI
    Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma. - PubMed - NCBI
    Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nucle... - PubMed - NCBI
    Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments. - PubMed - NCBI
    Preventive effects of vitamin K on recurrent disease in patients with hepatocellular carcinoma arising from hepatitis C viral infection. - PubMed - NCBI
    The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treat... - PubMed - NCBI
    [Vitamin K2 therapy for myelodysplastic syndrome]. - PubMed - NCBI
    Menatetrenone, a vitamin K2 analog, ameliorates cytopenia in patients with refractory anemia of myelodysplastic syndrome. - PubMed - NCBI
    Vitamin K2 therapy for myelodysplastic syndromes (MDS) and post-MDS acute myeloid leukemia: information through a questionnaire survey of multi-cen... - PubMed - NCBI
    Successful therapy of myelodysplastic syndrome with menatetrenone, a vitamin K2 analog. - PubMed - NCBI
    Vitamin K2 combined with all-trans retinoic acid induced complete remission of relapsing acute promyelocytic leukaemia. - PubMed - NCBI
    Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid. - PubMed - NCBI
    https://www.glowm.com/pdf/Book-OvarianCancerTherapeutics-CC-BY-Ch13.pdf


    Neurological Health
    Vitamin K and brain function. - PubMed - NCBI
    Vitamin K: a structural basis for the design of novel neuroprotective agents? - PubMed - NCBI
    Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides. - PubMed - NCBI
    Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes. - PubMed - NCBI
    Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain. - PubMed - NCBI

    Testosterone
    Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. - PubMed - NCBI
    Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis. - PubMed - NCBI

    Estrogen
    Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism. - PubMed - NCBI
     
  7. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    14,487
    Gender:
    Male
    Location:
    USA / Europe
    Great, thank you.
     
  8. Mauritio

    Mauritio Member

    Joined:
    Feb 26, 2018
    Messages:
    296
    Gender:
    Male
    I dont know what you mean. But i have to tell you today i took 2x2 drops of Kuinone on scrotum and i felt super good! I guess it was the Energin that caused anxiety , i think thats more likely as I was able to reproduce the symptoms after not haven taken it for the whole day.
     
  9. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    14,487
    Gender:
    Male
    Location:
    USA / Europe
    Sorry, the forum software automatically include a partial quote in my response to you. I edited my original post.
    Glad to hear Kuinone is having this effect. It seems to be pretty consistent across most males who tried it.
     
  10. mercutio

    mercutio Member

    Joined:
    May 18, 2017
    Messages:
    25
    Gender:
    Male
    it seems the new kuinone is using fema 2415 too now.
     
  11. mercutio

    mercutio Member

    Joined:
    May 18, 2017
    Messages:
    25
    Gender:
    Male
    it seems the new kuinone is using fema 2415 too now.
     
  12. mercutio

    mercutio Member

    Joined:
    May 18, 2017
    Messages:
    25
    Gender:
    Male
  13. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    14,487
    Gender:
    Male
    Location:
    USA / Europe
    It is an add-on, not the only solvent. Only 1 batch, because we wanted to see if it increases transdermal absorption.
     
  14. James b

    James b Member

    Joined:
    May 10, 2018
    Messages:
    48
    Gender:
    Male
    How are you measuring the degree to which it is/isn’t?
     
  15. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    14,487
    Gender:
    Male
    Location:
    USA / Europe
    No way to measure this directly as there does not seem to be a blood test for MK-4. But there are a studies with other chemical like steroids and antihistamine showing ~30% increased absorption when FEMA 2415 is added compared to when just ethanol is used.
     
Loading...