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Kuinone - Liquid Vitamin K2 (MK-4)

Discussion in 'IdeaLabs' started by haidut, Jan 11, 2016.

  1. Amazoniac

    Amazoniac Member

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    Zeus, I don't know how the body adapts to such doses over time and if it's something desirable to do often, but I know that those are enough to reach very high blood levels in relation to what's common for diet. This is it:


    Now compare 1/2 lb. of spinach (1 mg of K1) and 25 g of butter with 1 mg of M and K and Hyphen and Four and 5 g of butter:


    The ng equivalence for pmol is lower but it's in the orders of magnetisms higher there.
    It's better to spread the dose either way. Too little fat in a meal doesn't seem to be an issue for supplements. Turrine and taumeric can also be consumed along.
     
  2. Amazoniac

    Amazoniac Member

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    Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women

    "A single dose of MK-4 (420 μg; 945 nmol) or MK-7 (420 μg; 647 nmol) was administered to each subject within 10 min after ingesting a breakfast containing 13–17 g of fat."

    Fig 1.
    [​IMG]
    "Each point represents the mean ± SEM [standard error] of 5 subjects at 0, 2, 4, 6, 10, 24, 48 and 72 h. ■=MK-4; ○=MK-7"
    :confused2 They were after K in one vs K2 in other?
     
  3. Kayo

    Kayo Member

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    @haidut
    Is this solution is a universal solvent that anything on your skin will be transported into your blood along with it? Such as dmso? Should I be careful of something harmful transferring to my blood aside from the k2 that may be on my hands or skin?
     
  4. managing

    managing Member

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    How does oral supplement of K2 affect the liver? The reason I ask is I took this orally instead of topically a couple of times over the weekend. Got a moderately strong headache and very fast bowels. Not diarrhea at all, but very fast. Like 4 one day and 5 times the next. I felt particularly good the first day. Second day is when the headache came.

    Or perhaps it was something else.
     
  5. Krollic

    Krollic Member

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    Enjoying the product @haidut :]
    Teeth feels super smooth and I'm feeling good. I'm taking about 3 drops x 3 times a day.

    Do you reckon there is any benefit to me supplementing mk7? It's not present in my diet
     
  6. kayumochi

    kayumochi Member

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    6-7 drops of Kuinone (orally) prevents any bruising from aspirin.
     
  7. managing

    managing Member

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    Tried again and no headache. But a distinct ache in the medial umbilical ligament (connects belly button to bladder).

    The energy and focus from taking it orally once or twice a day is amazing. Just trying to figure out of these side effects are transient or cause for concern.

    Anybody?
     
  8. Owen B

    Owen B Member

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    What specifically did Weston Price mean by "the Western diet"?
     
  9. Obi-wan

    Obi-wan Member

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    Our modern Standard American Diet (SAD) diet of white sugar, white flour, processed food
     
  10. Ron J

    Ron J Member

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    @haidut
    Does CoQ10 interfere with MK4 absorption?
    Edit: I looked it up in drug interactions, just making sure.
     
  11. OP
    haidut

    haidut Member

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    I don't think MK-7 has anything to offer that MK-4 does not, and MK-4 is the actual vitamin our bodies use for osteocalcin carboxylation and electron transfer in the ETC.
     
  12. OP
    haidut

    haidut Member

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    Excellent, thanks for sharing! How much aspirin did you find it can buffer the bleeding risk from?
     
  13. OP
    haidut

    haidut Member

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    No, I don't think it does and even if it did MK-4 can substitute for CoQ10 for its electron transport duties. That's why Peat says vitamin K is better when people ask him about supplementing with CoQ10.
     
  14. OP
    haidut

    haidut Member

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    The concern about DMSO getting harmful pathogens into the blood of probably overblown because it would depend on molar mass and most pathogens have mass in the kD range that is beyond what can be properly absorbed. That being said, The ethanol in the solution we use should have a decent antiseptic effect and reduce risk even further. I don't think it would draw much other junk with itself through the skin but leaning the skin beforehand is probably not a bad idea since it should improve absorption by removing sebum and waxes.
     
  15. Obi-wan

    Obi-wan Member

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    I am experimenting with a new application technique for Kuinone. 4 drops on my spin tooth brush after toothpaste brushing...
     
  16. kayumochi

    kayumochi Member

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    I have never taken more than 500 mg but can begin bruising at doses as low as 81 mg.
     
  17. Phyllus

    Phyllus New Member

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    Wonderig if anyone here knows how much k2- mk4 to dose a 27 lb dog that was recently diagnosed with anal gland adenocarcinoma and hypercalcemia. He is 11 years old. Thanks.
     
  18. OP
    haidut

    haidut Member

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    I would ask a vet but from a few published tables on animal/human conversion between dog and humans it seems like the human dose needs to be multiples by 2. So, the commonly used dose for humans in clinical cancer trials is 1mg/kg, which means 2mg/kg for a dog.
     
  19. kayumochi

    kayumochi Member

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    Have been taking Kuinone orally for a 1+ and didn't know there was a formulation that contained camphor until this week ... what a surprise when those drops hit the back of my throat :)
     
  20. raypeatclips

    raypeatclips Member

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    Does your bottle say camphor on it?
     
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