Kuinone - Liquid, High-dose Vitamin K2 (MK-4) Supplement

Discussion in 'IdeaLabs' started by haidut, Jan 11, 2016.

  1. Tarmander

    Tarmander Member

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    If you addressed this somewhere else I apologize, but what would be your best bet on the conversion of this topical form to oral? The 1.5mg from one drop already feels about as strong as the 5mg pill I was testing.
     
  2. OP
    haidut

    haidut Member

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    I am about to post some studies on steroids showing if dissolve them in DMSO you get 3 - 10 times better bioavailability. So, at a minimum, I expect 1 drop of Kuinone to be about equal to 4mg - 5mg Thorne or other products, which matches well your guess and experience.
     
  3. Tarmander

    Tarmander Member

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    Thank you!
     
  4. narouz

    narouz Member

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    I guess this might be why I'm having a hard time getting a handle on
    how to dose your NDT in DMSO, haidut.
    If it increases bioavailability 10 fold....
     
  5. OP
    haidut

    haidut Member

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  6. narouz

    narouz Member

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  7. johnwester130

    johnwester130 Member

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    How does this compare to mk7 ?

    Also, will DMSO increase the half life ?

    and do you believe in a calcification of the skull bones, that may cause hair loss ?
     
  8. tara

    tara Member

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    Unless Peat is right, and it needs to be digested by the gut to be useful.
    From Cantstoppeating:
     
  9. Tarmander

    Tarmander Member

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    Hey Haidut. When I started taking this topical k, I also changed a few other things around, and noticed some thinning and receding hair. I am trying to nail down exactly what is doing it. Any chance the K might be a factor? Reduced calcium in the blood raising prolactin or something? Also been doing more salt, little less protein, more sun, less topical DHEA and preg (haven't felt I've needed it with this K), and a few other things. Can't figure it out.
     
  10. OP
    haidut

    haidut Member

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    As I have said many times on the forum, I prefer vitamin K2 (MK-4). Most of the research on MK-7 is suspect and sponsored by companies producing it. There is a reason only MK-4 is approved as osteoporosis drug in Japan, Korea, Vietnam, etc.
    As far as the half-life, anything that absorbs through the skin tends to have longer half life due to the lower impact of hepatic metabolism. I encourage people to do blood tests to confirm effects and half-life.
     
  11. OP
    haidut

    haidut Member

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    All I can say is that not all NDT's are created equal.
     
  12. dadon

    dadon Member

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    Hey,
    So I´ve been using Kuinone for a few days now. Most of the days I applied it topically (1-2 Drops) and once orally (one drop).

    I´ve noticed that it reduced my white tongue, there seems to be less built-up on my teeth (which I´ve destroyed 2 years ago due to making a lot of mistake eating this "peat" way and neglecting hygiene) and my gums appear less red which is a good sign. Those are the effects I was hoping for when I bought it.

    I´m still sceptical about the DMSO. As others have mentioned previously it may sting and cause skin rashes (yesterday after applying it to the crook of my arm the skin got really inflamed). But when the drops hit the skin it feels like they interact with the skin pretty quickly. Let´s hope it is safe enough for daily use.

    My issue (that I have mentioned to haidut in an e-mail) is that Kuinone leaves a yellow residue on the skin (and I mean REALLY yellow almost as I´d have dipped it in color). The same also happens with the energin supp. Is there any way to determine how much of those supplements is absorbed? Haidut has mentioned absorption rates of up to 80%, but judging from the intensity of the color they seem to just stick to the skin.
     
  13. cpaqf1

    cpaqf1 Member

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    I already emailed him about it, here was his response:

    Yes, it is normal to stain as all quinones do the same. CoQ10 also stains as does emodin and the other quinones. The full absorption takes up to a day, but about 80% of the vitamin absorbs within the first hour. Our product Energin also stains but people have confirmed by blood tests that virtually all of it absorbs through the skin.
     
  14. dadon

    dadon Member

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    I got a similar Reply from him. Then he referred me to this thread, so I don´t want to bother him anymore. Do you know how long it took for the energin to absorb through the skin? When I took it orally it didn´t do much (although I might have got more cold). Yesterday I put some on my wrists and it made me tired quickly (relaxed in a good way).
     
  15. OP
    haidut

    haidut Member

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    Thanks for the feedback on Kuinone!
    There is study posted in the Energin thread that says up to 90% of the B vitamins it looked at are absorbed within the first hour and then there is a "long-tail" of absorbing the other 10%-20% over the next 24 hours.
    Methylene blue applied topically has a very similar effect on skin coloring and also on absorption kinetics. Most of it absorbs within the first 2 hours and then the remiander can take up to several days to absorb. Google "methylene blue topical absorption" for more info.
     
  16. whit

    whit Member

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    I had the same thing happen with the staining. When I cover it with estoban then some stressnon the color fades away quite quickly. Its likely carrying the rest through.
    Give it a try and see if you get the same effect.
     
  17. whit

    whit Member

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    We also use coconut oil to dilute a little as well.
     
  18. X160

    X160 Member

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    Feedback: This product has made tremendous difference to my dental heath. My gums used to bleed every-time I used to brush and I used to get a lot of plaque too. All these issues are gone now.
    I also notice a subtle rise in libido.
     
  19. whit

    whit Member

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    Haidut, is there any particular protocol you've come across to cleaning the skin before application of topicals?
    I've been looking but haven't seen anything on it.
    Thanks.
     
  20. Miggie

    Miggie Member

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    What is your dosage and how long have you been using it?

    I'm going to order a few bottles of this as well soon and then try 30mg a day to see if my jaw will grow wider.
     
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