Kuinone - Liquid Vitamin K2 (MK-4)

[DesertRat]

Can one put it directly on teeth or gums? Would it help strengthen the teeth to prevent cavities or heal from damage to roots from dental drills?

Looking forward to trying it as Thorne is running out.

 

[DesertRat]

I wrote to Peat about my recent electric sensitivity when I discovered taking aspirin makes it worse. He said that low K can lead to increased sensitivities.

I've been taking 10 drops a day of Thorne K2 to 450 mg aspirin, but I get the increased sensitivity to 100 mg.

 

[haidut]

post 118916 Haidut -if I'm using k2 for cleaning up a fatty liver how would the transdermal route work? I thought applying on skin bypassed the liver. Thx.

It bypasses first pass metabolism, but not second pass. Second pass metabolism is the drug coming back to the liver from the blood circulation. So, the liver will get some no matter what. The good thing about the topical administration is that vitamin K will achieve much higher concentration in the blood and allow the organs that really need it (bones, brain) to get a decent dose and not just the liver.
Btw, Peat takes all of his fat soluble vitamins topically.

 

[haidut]

post 118927 Can one put it directly on teeth or gums? Would it help strengthen the teeth to prevent cavities or heal from damage to roots from dental drills?

Looking forward to trying it as Thorne is running out.

You can put it on gums, even though it is not meant for such use. As far as whether it would help with cavities, this is an effectiveness question which I am not legally allowed to answer.

 

[InChristAlone]

lol at the references!!!

This is great Haidut thank-you!

 

[haidut]

post 119005 lol at the references!!!

This is great Haidut thank-you!

Well, I think many people don't realize how versatile a substance vitamin K is and how beneficial for health it is. Hopefully, when doctors see this mountain of references they'll change their mind about vitamin K being nothing more than a blood coagulation factor.

 

[scarlettsmum]

Great! Especially as only 1 drop is needed.

 

[haidut]

post 119223 Great! Especially as only 1 drop is needed.

Yep, that's the goal really. Kuinone is cheaper than Thorne in terms of $$/mg of vitamin K and it should also last people much longer than Thorne's supplement. I am not interested in people buying from me every month. I am interested in people improving their health.

 

[scarlettsmum]

post 119228

post 119223 Great! Especially as only 1 drop is needed.

Yep, that's the goal really. Kuinone is cheaper than Thorne in terms of $$/mg of vitamin K and it should also last people much longer than Thorne's supplement. I am not interested in people buying from me every month. I am interested in people improving their health.

That's why we love you, Haidut! :))

 

[honeybee]

post 118943

post 118916 Haidut -if I'm using k2 for cleaning up a fatty liver how would the transdermal route work? I thought applying on skin bypassed the liver. Thx.

It bypasses first pass metabolism, but not second pass. Second pass metabolism is the drug coming back to the liver from the blood circulation. So, the liver will get some no matter what. The good thing about the topical administration is that vitamin K will achieve much higher concentration in the blood and allow the organs that really need it (bones, brain) to get a decent dose and not just the liver.
Btw, Peat takes all of his fat soluble vitamins topically.

post 118943

post 118916 Haidut -if I'm using k2 for cleaning up a fatty liver how would the transdermal route work? I thought applying on skin bypassed the liver. Thx.

Thank you!
I am working my way through my bottle of throne's k2 and seeing good results re: cleaning fatty liver. Ill have to give your's a try.

 

[johnwester130]

isn't this fat soluble ?

 

[haidut]

post 119278 isn't this fat soluble ?

Yes, it is fat soluble but it is also soluble in DMSO.

 

[Koveras]

Does anyone have access to the full study here?

Thank you

http://www.ncbi.nlm.nih.gov/pubmed/19894328

 

[haidut]

post 119536 Does anyone have access to the full study here?

Thank you

http://www.ncbi.nlm.nih.gov/pubmed/19894328

I don't have a copy but I emailed the author long time ago and he responded that the abstract has a typo. It is not 45mg three times a day for a total of 135mg. It is 15mg three times a day. However, he said that for cancer therapy the 45mg three times a day is a viable approach. He mentioned leukemia and prostate cancer as two examples. Very similar to the 100mg - 150mg dose of the vitamin K cousin doxycycline used for cancer treatment in the other studies I have posted.

 

[onioneyedox]

I don't know if this is plausible, but I have noticed smoother skin lately. Actually, It caught my eye the very first morning after using Kuinone (topically, few drops) that skin of back of my hand was sort of glowing. Now when I inspect my skin it seems smoother, not the "big" wrinkles, but the very "micro structure", for example, around biceps/shoulder (area of where skin has seemed sort of weak). And face too seems glowing more (not shining). Now, I have been using vitamin k before, thorne and others, but never have noticed such effect (if at all), so I'm not sure if it just something that has started to happen now, as I have been improving slowly over the years, and I just somehow happened to notice it now. Or maybe my oral route is somehow compromised, I don't know, your other topical supps seems to be rather good too. Or maybe it is the solvent DMSO, as I used one bottle of EstroBan last year, but didn't notice much effect. Certainly starting to think them as a gold standard of supplements.

 

[tristan1234]

Congrats Haidut, this looks cool. I just wish you'd included a reference or two in your post :)

Hey Dan, any chance you could run your little titling trick on the references?

 

[Dan W]

Hey Dan, any chance you could run your little titling trick on the references?

Yep, but let me check with the mods. Maybe if they just edit and resubmit Haidut's post it'll be transformed by the new auto-link-titling feature.

 

[Dan W]

"Title-ified" references:

General

• Highly recommended dose of MK4 for osteoporosis.
• Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy.
• Vitamin E and K interactions--a 50-year-old problem.
• Pleiotropic actions of vitamin K: protector of bone health and beyond?
• Exocrine pancreatic secretion of phospholipid, menaquinone-4, and caveolin-1 in vivo.
• Improvement of vitamin K status of breastfeeding infants with maternal supplement of vitamin K2 (MK40).
• Antinociceptive effect induced by intraperitoneal administration of vitamin K2 (menatetrenone) in ICR mice.
• Effect of dietary fat content on oral bioavailability of menatetrenone in humans.
• Effect of food composition on vitamin K absorption in human volunteers.
• Distribution of menaquinone-4, a therapeutic agent for osteoporosis, in bone and other tissues of rats.

Bone Health

• Treatment of glucocorticoid-induced low bone mineral density in children: a systematic review.
• Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study.
• Vitamin K2 improves femoral bone strength without altering bone mineral density in gastrectomized rats.
• Vitamin K₂ therapy for postmenopausal osteoporosis.
• Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair.
• Menatetrenone versus alfacalcidol in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, do...
• Effects of vitamin K in postmenopausal women: mini review.
• Menatetrenone for the treatment of osteoporosis.
• Strategy for prevention of hip fractures in patients with Parkinson's disease.
• Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone.
• Amelioration of pregnancy-associated osteoporosis after treatment with vitamin K₂: a report of four patients.
• Clinical results of alendronate monotherapy and combined therapy with menatetrenone (VitK in postmenopausal RA patients.
• Bridging the gap between osteoporosis and osteonecrosis of the jaw: preventing and treating BRONJ with MK4.
• Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral de...
• The prevention of hip fracture with menatetrenone and risedronate plus calcium supplementation in elderly patients with Alzheimer disease: a random...
• Effect of vitamin K2 on cortical and cancellous bone mass and hepatic lipids in rats with combined methionine-choline deficiency.
• Effect of GGCX gene polymorphism on the responses of serum undercarboxylated osteocalcin and bone turnover markers after treatment with vitamin K2 ...
• Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats.
• Vitamin K₂ alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level.
• Effects of vitamin K2 on cortical and cancellous bone mass, cortical osteocyte and lacunar system, and porosity in sciatic neurectomized rats.
• Vitamin K2 promotes bone healing in a rat femoral osteotomy model with or without glucocorticoid treatment.
• Effects of combination treatment with alendronate and vitamin K(2) on bone mineral density and strength in ovariectomized mice.
• Prevention of hip fractures by exposure to sunlight and pharmacotherapy in patients with Alzheimer's disease.
• Vitamin K to prevent fractures in older women: systematic review and economic evaluation.
• Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -indep...
• Efficacy of menatetrenone (vitamin K2) against non-vertebral and hip fractures in patients with neurological diseases: meta-analysis of three rando...
• Comparison of the effect of vitamin K(2) and risedronate on trabecular bone in glucocorticoid-treated rats: a bone histomorphometry study.
• Collagen-related abnormalities, reduction in bone quality, and effects of menatetrenone in rats with a congenital ascorbic acid deficiency.
• Prior treatment with vitamin K(2) significantly improves the efficacy of risedronate.
• Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover in postmenopausal osteoporo...
• Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North Am...
• Randomized controlled study on the prevention of osteoporotic fractures (OF study): a phase IV clinical study of 15-mg menatetrenone capsules.
• Vitamin K2, a gamma-carboxylating factor of gla-proteins, normalizes the bone crystal nucleation impaired by Mg-insufficiency.
• [Treatment of primary osteoporosis with vitamin K2].
• [Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function].
• Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells.
• Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene.
• Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women.
• Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis.
• Beneficial effect of pretreatment and treatment continuation with risedronate and vitamin K2 on cancellous bone loss after ovariectomy in rats: a b...
• Infrared analysis of bones in magnesium-deficient rats treated with vitamin K2.
• [Active vitamin D and vitamin K as therapeutic agents for osteoporosis].
• [Diabetic osteopahty and vitamin K].
• [Therapeutic approaches for diabetic osteopahty].
• Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia.
• Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats.
• Comparative effects of vitamin K and vitamin D supplementation on calcium balance in young rats fed normal or low calcium diets.
• [The interplay of magnesium and vitamin K2 on bone mineralization].
• [Vitamin K2 and bone quality].
• [Vitamin K2 (menatetrenone) and bone quality].
• Effects of vitamin K2 administration on calcium balance and bone mass in young rats fed normal or low calcium diet.
• Menatetrenone rescues bone loss by improving osteoblast dysfunction in rats immobilized by sciatic neurectomy.
• Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer's disease.
• Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG).
• Effects of vitamin K2 (menatetrenone) and alendronate on bone mineral density and bone strength in rats fed a low-magnesium diet.
• Histochemical evaluation for the biological effect of menatetrenone on metaphyseal trabeculae of ovariectomized rats.
• Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels.
• Vitamin K2 and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner.
• Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine.
• Menatetrenone ameliorates reduction in bone mineral density and bone strength in sciatic neurectomized rats.
• Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis.
• Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors.
• High serum levels of menatetrenone in male patients with ossification of the posterior longitudinal ligament.
• Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa.
• Effect of vitamin K2 on cortical and cancellous bones in orchidectomized and/or sciatic neurectomized rats.
• Vitamin K stimulates osteoblastogenesis and inhibits osteoclastogenesis in human bone marrow cell culture.
• Effect of vitamin K2 on cortical and cancellous bones in orchidectomized young rats.
• Pharmacodynamics of menatetrenone and effects on bone metabolism in continuous ambulatory peritoneal dialysis patients.
• Vitamin K2 (menatetrenone) inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats.
• Menatetrenone prevents osteoblast dysfunction in unilateral sciatic neurectomized rats.
• [Effect of menatetrenone (V.K2) on bone mineral density and bone strength in Ca/Mg deficient rats].
• Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal women.
• Maintenance of trabecular structure and bone volume by vitamin K(2) in mature rats with long-term tail suspension.
• Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency.
• A comparison of alfacalcidol and menatetrenone for the treatment of bone loss in an ovariectomized rat model of osteoporosis.
• Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver.
• Effects of phenytoin and/or vitamin K2 (menatetrenone) on bone mineral density in the tibiae of growing rats.
• Effects of vitamin K2 (menatetrenone) on calcium balance in ovariectomized rats.
• Efficacy and safety of Menatetrenone-4 postmenopausal Thai women.
• Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency.
• Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: a comparison with t...
• Effects of vitamin K on calcium and bone metabolism.
• Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) tre...
• Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
• [Effects of vitamin K2 administration in the patients with severely motor and intellectual disabilities: assessment of bone metabolic marker and bo...
• Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures.
• Effect of vitamin K2 on three-dimensional trabecular microarchitecture in ovariectomized rats.
• Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.
• Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis.
• Menatetrenone plus alfacalcidol treatment for bone problems in eight children with skeletal unloading.
• [Vitamin K2 (menatetrenone) treatment increased bone strength in rats given low-calcium diets].
• Inhibitory effect of vitamin K2 (menatetrenone) on bone resorption in ovariectomized rats: a histomorphometric and dual energy X-ray absorptiometri...
• Use of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolide.
• A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-p...
• [Effects of a vitamin K2 preparation in severely handicapped patients complicated by osteopenia].
• Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients.
• Vitamin K2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro.
• Vitamin K2 promotes 1alpha,25(OH)2 vitamin D3-induced mineralization in human periosteal osteoblasts.
• The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain.
• Effect of vitamin K2 (menatetrenone) on osteoclast-like cell formation in mouse bone marrow cultures.
• [Influence of vitamin D3 on inhibitory effect of vitamin K2 on bone loss in ovariectomized rats].
• Effects of menatetrenone on the decrease in calcium balance induced by vitamin K-deficient diet and sodium loading in rats.
• Effects of menatetrenone on prednisolone-induced bone loss in rats.
• Effects of menatetrenone on bone loss induced by ovariectomy in rats.
• Vitamin K2 modulates proliferation and function of osteoblastic cells in vitro.

Inflammation

• Vitamin K2 (menatetrenone) inhibits prostaglandin synthesis in cultured human osteoblast-like periosteal cells by inhibiting prostaglandin H syntha...
• Menatetrenone inhibits bone resorption partly through inhibition of PGE2 synthesis in vitro.

Cardiovascular disease (CVD)

• Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease.
• Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification.
• Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats.
• Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits.
• Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains.

Diabetes

• Vitamin K₂ prevents hyperglycemia and cancellous osteopenia in rats with streptozotocin-induced type 1 diabetes.
• Antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice.

Kidney Health

• Vitamin K(2) improves renal function and increases femoral bone strength in rats with renal insufficiency.

Cancer

• Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controll...
• Role of vitamin K2 in preventing the recurrence of hepatocellular carcinoma after curative treatment: a meta-analysis of randomized controlled trials.
• Chemoprevention of chemically-induced biliary carcinogenesis in hamsters by vitamin K2.
• Effect of vitamin K2 on the development of hepatocellular carcinoma in type C cirrhosis.
• Soluble VEGF receptor-2 may be a predictive marker of anti-angiogenic therapy with clinically available safe agents.
• Vitamin analogues in chemoprevention of hepatocellular carcinoma after resection or ablation--a systematic review and meta-analysis.
• Vitamin K2 augments 5-fluorouracil-induced growth inhibition of human hepatocellular carcinoma cells by inhibiting NF-κB activation.
• Multicenter phase II trial of vitamin K(2) monotherapy and vitamin K(2) plus 1alpha-hydroxyvitamin D(3) combination therapy for low-risk myelodyspl...
• Inhibition of matrix metalloproteinase expression by menatetrenone, a vitamin K2 analogue.
• Vitamin K2 suppresses proliferation and motility of hepatocellular carcinoma cells by activating steroid and xenobiotic receptor.
• Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma.
• Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma.
• Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nucle...
• Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments.
• Preventive effects of vitamin K on recurrent disease in patients with hepatocellular carcinoma arising from hepatitis C viral infection.
• The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treat...
• [Vitamin K2 therapy for myelodysplastic syndrome].
• Menatetrenone, a vitamin K2 analog, ameliorates cytopenia in patients with refractory anemia of myelodysplastic syndrome.
• Vitamin K2 therapy for myelodysplastic syndromes (MDS) and post-MDS acute myeloid leukemia: information through a questionnaire survey of multi-cen...
• Successful therapy of myelodysplastic syndrome with menatetrenone, a vitamin K2 analog.
• Vitamin K2 combined with all-trans retinoic acid induced complete remission of relapsing acute promyelocytic leukaemia.
• Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid.

Neurological Health

• Vitamin K and brain function.
• Vitamin K: a structural basis for the design of novel neuroprotective agents?
• Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides.
• Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes.
• Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain.

Testosterone

• Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells.
• Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis.

Estrogen

• Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism.

 

[Tarmander]

I wanted to give some feedback on this product.

I have been using it for a little over a week, maybe two. I put one drop on my chest/stomach area at night before sleep and let it absorb before going to bed ( definitely can get yellow on your sheets if you aren't careful).

I have a pill form of k2 that was 5mg. I would take it in the morning and feel tired for a few hours, then I wouldn't be able to sleep at night. So I resigned myself to just taking what was in estroban and no extra K2.

So when I got this topical K2, I decided to try it at night due to the drowsiness I usually experience on it.

I have had an overwhelmingly positive experience. I have been sleeping much better, often all the way through the night. I have also seemingly had a huge boost in testosterone, although I don't have labs to show that. Libido has really skyrocketed though.

Also a lingering cough that would develop if I drank too much milk is pretty much gone, no mucus or phlegm cough up in the morning.

The one draw back is that it does produce some drowsiness the next day, from what I am assuming is a lowering of stress hormones. A couple times I have woken up at night to hit the bathroom and practically felt dizzy and disoriented.

I think this is a great product and probably one of the best values simply for how much you get and how little you need. I am going to try an up the dose to two drops here when I can afford to take the next day off. If anyone is having a tough time taking k2, I suggest trying it before bed.

 

[haidut]

I wanted to give some feedback on this product.

I have been using it for a little over a week, maybe two. I put one drop on my chest/stomach area at night before sleep and let it absorb before going to bed ( definitely can get yellow on your sheets if you aren't careful).

I have a pill form of k2 that was 5mg. I would take it in the morning and feel tired for a few hours, then I wouldn't be able to sleep at night. So I resigned myself to just taking what was in estroban and no extra K2.

So when I got this topical K2, I decided to try it at night due to the drowsiness I usually experience on it.

I have had an overwhelmingly positive experience. I have been sleeping much better, often all the way through the night. I have also seemingly had a huge boost in testosterone, although I don't have labs to show that. Libido has really skyrocketed though.

Also a lingering cough that would develop if I drank too much milk is pretty much gone, no mucus or phlegm cough up in the morning.

The one draw back is that it does produce some drowsiness the next day, from what I am assuming is a lowering of stress hormones. A couple times I have woken up at night to hit the bathroom and practically felt dizzy and disoriented.

I think this is a great product and probably one of the best values simply for how much you get and how little you need. I am going to try an up the dose to two drops here when I can afford to take the next day off. If anyone is having a tough time taking k2, I suggest trying it before bed.

Thank you for the excellent feedback! I also experience drowsiness from things that improve metabolism and those include T3, methylene blue, beta-lapachone, emodin, and of course vitamin K2. For that reason, if I take any of these I do it at night.