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Kuinone - Liquid, High-dose Vitamin K2 (MK-4) Supplement

Discussion in 'IdeaLabs' started by haidut, Jan 11, 2016.

  1. haidut

    haidut Member

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    Over the last year a number of people on the forum asked me to release a vitamin K2 supplement as an alternative to the popular (but expensive) Thorne K2 supplement. So, I finally got around to delivering on my promise. Kuinone is a liquid dietary supplement with menatetrenone (MK-4) dissolved in ethanol and SFA esters. If you are wondering what's up with the weird name, well it is a play on the fact that vitamin K is a naphthoquinone, or a type of (q)uinone just like the well-known CoQ10. So, I combined the K from vitamin K and the word quinone to form Kuinone. Hopefully, it is not too confusing to people what the word means.
    The fact that it is dissolved in SFA esters + ethanol mixture should dramatically improve topical absorption and allow a much lower daily dose to be used, which will make the bottle last much longer and thus further decrease the overall cost.
    Finally, while the bone benefits of vitamin K2 are known to many people on the forum, some of its "niche" effects are not widely known. So, I compiled a (long) list of references broken down by categories for the people who are interested in finding out more about this amazing substance.

    *******************************************************************************
    Kuinone is a dietary supplement containing vitamin K2 (MK-4) also known as menatetrenone. This product, while consisting entirely of food-grade ingredients, is sanctioned for external use only.

    Servings per container: about 720
    Serving size: 1 drop
    Each serving contains the following ingredients:

    Vitamin K2 (MK-4) - 1.5mg

    Other ingredients: SFA esters, ethanol
    *******************************************************************************

    References:

    General
    Highly recommended dose of MK4 for osteoporosis. - PubMed - NCBI
    Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy. - PubMed - NCBI
    Vitamin E and K interactions--a 50-year-old problem. - PubMed - NCBI
    Pleiotropic actions of vitamin K: protector of bone health and beyond? - PubMed - NCBI
    Exocrine pancreatic secretion of phospholipid, menaquinone-4, and caveolin-1 in vivo. - PubMed - NCBI
    Improvement of vitamin K status of breastfeeding infants with maternal supplement of vitamin K2 (MK40). - PubMed - NCBI
    Antinociceptive effect induced by intraperitoneal administration of vitamin K2 (menatetrenone) in ICR mice. - PubMed - NCBI
    Effect of dietary fat content on oral bioavailability of menatetrenone in humans. - PubMed - NCBI
    Effect of food composition on vitamin K absorption in human volunteers. - PubMed - NCBI
    Distribution of menaquinone-4, a therapeutic agent for osteoporosis, in bone and other tissues of rats. - PubMed - NCBI


    Bone Health
    Treatment of glucocorticoid-induced low bone mineral density in children: a systematic review. - PubMed - NCBI
    Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. - PubMed - NCBI
    Vitamin K2 improves femoral bone strength without altering bone mineral density in gastrectomized rats. - PubMed - NCBI
    Vitamin K₂ therapy for postmenopausal osteoporosis. - PubMed - NCBI
    Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. - PubMed - NCBI
    Menatetrenone versus alfacalcidol in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, do... - PubMed - NCBI
    Effects of vitamin K in postmenopausal women: mini review. - PubMed - NCBI
    Menatetrenone for the treatment of osteoporosis. - PubMed - NCBI
    Strategy for prevention of hip fractures in patients with Parkinson's disease. - PubMed - NCBI
    Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone. - PubMed - NCBI
    Amelioration of pregnancy-associated osteoporosis after treatment with vitamin K₂: a report of four patients. - PubMed - NCBI
    Clinical results of alendronate monotherapy and combined therapy with menatetrenone (VitK₂) in postmenopausal RA patients. - PubMed - NCBI
    Bridging the gap between osteoporosis and osteonecrosis of the jaw: preventing and treating BRONJ with MK4. - PubMed - NCBI
    Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral de... - PubMed - NCBI
    The prevention of hip fracture with menatetrenone and risedronate plus calcium supplementation in elderly patients with Alzheimer disease: a random... - PubMed - NCBI
    Effect of vitamin K2 on cortical and cancellous bone mass and hepatic lipids in rats with combined methionine-choline deficiency. - PubMed - NCBI
    Effect of GGCX gene polymorphism on the responses of serum undercarboxylated osteocalcin and bone turnover markers after treatment with vitamin K2 ... - PubMed - NCBI
    Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats. - PubMed - NCBI
    Vitamin K₂ alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level. - PubMed - NCBI
    Effects of vitamin K2 on cortical and cancellous bone mass, cortical osteocyte and lacunar system, and porosity in sciatic neurectomized rats. - PubMed - NCBI
    Vitamin K2 promotes bone healing in a rat femoral osteotomy model with or without glucocorticoid treatment. - PubMed - NCBI
    Effects of combination treatment with alendronate and vitamin K(2) on bone mineral density and strength in ovariectomized mice. - PubMed - NCBI
    Prevention of hip fractures by exposure to sunlight and pharmacotherapy in patients with Alzheimer's disease. - PubMed - NCBI
    Vitamin K to prevent fractures in older women: systematic review and economic evaluation. - PubMed - NCBI
    Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -indep... - PubMed - NCBI
    Efficacy of menatetrenone (vitamin K2) against non-vertebral and hip fractures in patients with neurological diseases: meta-analysis of three rando... - PubMed - NCBI
    Comparison of the effect of vitamin K(2) and risedronate on trabecular bone in glucocorticoid-treated rats: a bone histomorphometry study. - PubMed - NCBI
    Collagen-related abnormalities, reduction in bone quality, and effects of menatetrenone in rats with a congenital ascorbic acid deficiency. - PubMed - NCBI
    Prior treatment with vitamin K(2) significantly improves the efficacy of risedronate. - PubMed - NCBI
    Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover in postmenopausal osteoporo... - PubMed - NCBI
    Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North Am... - PubMed - NCBI
    Randomized controlled study on the prevention of osteoporotic fractures (OF study): a phase IV clinical study of 15-mg menatetrenone capsules. - PubMed - NCBI
    Vitamin K2, a gamma-carboxylating factor of gla-proteins, normalizes the bone crystal nucleation impaired by Mg-insufficiency. - PubMed - NCBI
    [Treatment of primary osteoporosis with vitamin K2]. - PubMed - NCBI
    [Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function]. - PubMed - NCBI
    Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. - PubMed - NCBI
    http://www.ncbi.nlm.nih.gov/pubmed/17875939
    http://www.ncbi.nlm.nih.gov/pubmed/17287908
    http://www.ncbi.nlm.nih.gov/pubmed/17274493
    http://www.ncbi.nlm.nih.gov/pubmed/17190100
    http://www.ncbi.nlm.nih.gov/pubmed/17187189
    http://www.ncbi.nlm.nih.gov/pubmed/16972672
    http://www.ncbi.nlm.nih.gov/pubmed/16883044
    http://www.ncbi.nlm.nih.gov/pubmed/16883037
    http://www.ncbi.nlm.nih.gov/pubmed/16594930
    http://www.ncbi.nlm.nih.gov/pubmed/16362462
    http://www.ncbi.nlm.nih.gov/pubmed/16261991
    http://www.ncbi.nlm.nih.gov/pubmed/15995297
    http://www.ncbi.nlm.nih.gov/pubmed/15995296
    http://www.ncbi.nlm.nih.gov/pubmed/15930719
    http://www.ncbi.nlm.nih.gov/pubmed/15886487
    http://www.ncbi.nlm.nih.gov/pubmed/15698851
    http://www.ncbi.nlm.nih.gov/pubmed/15664003
    http://www.ncbi.nlm.nih.gov/pubmed/15616893
    http://www.ncbi.nlm.nih.gov/pubmed/15542039
    http://www.ncbi.nlm.nih.gov/pubmed/15454094
    http://www.ncbi.nlm.nih.gov/pubmed/15003806
    http://www.ncbi.nlm.nih.gov/pubmed/14715241
    http://www.ncbi.nlm.nih.gov/pubmed/14712427
    http://www.ncbi.nlm.nih.gov/pubmed/14598912
    http://www.ncbi.nlm.nih.gov/pubmed/14529146
    http://www.ncbi.nlm.nih.gov/pubmed/14506958
    http://www.ncbi.nlm.nih.gov/pubmed/12923464
    http://www.ncbi.nlm.nih.gov/pubmed/12686368
    http://www.ncbi.nlm.nih.gov/pubmed/12674339
    http://www.ncbi.nlm.nih.gov/pubmed/12630919
    http://www.ncbi.nlm.nih.gov/pubmed/12568732
    http://www.ncbi.nlm.nih.gov/pubmed/12526283
    http://www.ncbi.nlm.nih.gov/pubmed/12477571
    http://www.ncbi.nlm.nih.gov/pubmed/12396032
    http://www.ncbi.nlm.nih.gov/pubmed/12271515
    http://www.ncbi.nlm.nih.gov/pubmed/12201222
    http://www.ncbi.nlm.nih.gov/pubmed/12115067
    http://www.ncbi.nlm.nih.gov/pubmed/12110423
    http://www.ncbi.nlm.nih.gov/pubmed/12073154
    http://www.ncbi.nlm.nih.gov/pubmed/12003435
    http://www.ncbi.nlm.nih.gov/pubmed/11895104
    http://www.ncbi.nlm.nih.gov/pubmed/11855678
    http://www.ncbi.nlm.nih.gov/pubmed/11853280
    http://www.ncbi.nlm.nih.gov/pubmed/11846334
    http://www.ncbi.nlm.nih.gov/pubmed/11793169
    http://www.ncbi.nlm.nih.gov/pubmed/11706280
    http://www.ncbi.nlm.nih.gov/pubmed/11403096
    http://www.ncbi.nlm.nih.gov/pubmed/11180916
    http://www.ncbi.nlm.nih.gov/pubmed/11144162
    http://www.ncbi.nlm.nih.gov/pubmed/11113387
    http://www.ncbi.nlm.nih.gov/pubmed/10977000
    http://www.ncbi.nlm.nih.gov/pubmed/10750566
    http://www.ncbi.nlm.nih.gov/pubmed/10652960
    http://www.ncbi.nlm.nih.gov/pubmed/10633277
    http://www.ncbi.nlm.nih.gov/pubmed/10621944
    http://www.ncbi.nlm.nih.gov/pubmed/10446758
    http://www.ncbi.nlm.nih.gov/pubmed/10443663
    http://www.ncbi.nlm.nih.gov/pubmed/10227010
    http://www.ncbi.nlm.nih.gov/pubmed/9844410
    http://www.ncbi.nlm.nih.gov/pubmed/9737352
    http://www.ncbi.nlm.nih.gov/pubmed/9076586
    http://www.ncbi.nlm.nih.gov/pubmed/8939773
    http://www.ncbi.nlm.nih.gov/pubmed/7756045
    http://www.ncbi.nlm.nih.gov/pubmed/7821350
    http://www.ncbi.nlm.nih.gov/pubmed/7927067
    http://www.ncbi.nlm.nih.gov/pubmed/8089928
    http://www.ncbi.nlm.nih.gov/pubmed/8155403
    http://www.ncbi.nlm.nih.gov/pubmed/8371513
    http://www.ncbi.nlm.nih.gov/pubmed/1530637

    Inflammation
    http://www.ncbi.nlm.nih.gov/pubmed/8240383
    http://www.ncbi.nlm.nih.gov/pubmed/8511981


    Cardiovascular disease (CVD)
    http://www.ncbi.nlm.nih.gov/pubmed/23344475
    http://www.ncbi.nlm.nih.gov/pubmed/18234293
    http://www.ncbi.nlm.nih.gov/pubmed/14654717
    http://www.ncbi.nlm.nih.gov/pubmed/9414028
    http://www.ncbi.nlm.nih.gov/pubmed/9247360

    Diabetes
    http://www.ncbi.nlm.nih.gov/pubmed/21136047
    http://www.ncbi.nlm.nih.gov/pubmed/11325029

    Kidney Health
    http://www.ncbi.nlm.nih.gov/pubmed/22080166

    Cancer
    http://www.ncbi.nlm.nih.gov/pubmed/23225445
    http://www.ncbi.nlm.nih.gov/pubmed/23191943
    http://www.ncbi.nlm.nih.gov/pubmed/21661384
    http://www.ncbi.nlm.nih.gov/pubmed/21410069
    http://www.ncbi.nlm.nih.gov/pubmed/22870131
    http://www.ncbi.nlm.nih.gov/pubmed/21163409
    http://www.ncbi.nlm.nih.gov/pubmed/21109972
    http://www.ncbi.nlm.nih.gov/pubmed/20569983
    http://www.ncbi.nlm.nih.gov/pubmed/19639210
    http://www.ncbi.nlm.nih.gov/pubmed/19550077
    http://www.ncbi.nlm.nih.gov/pubmed/19501932
    http://www.ncbi.nlm.nih.gov/pubmed/18251162
    http://www.ncbi.nlm.nih.gov/pubmed/17404108
    http://www.ncbi.nlm.nih.gov/pubmed/17399847
    http://www.ncbi.nlm.nih.gov/pubmed/17376044
    http://www.ncbi.nlm.nih.gov/pubmed/16400650
    http://www.ncbi.nlm.nih.gov/pubmed/11925874
    http://www.ncbi.nlm.nih.gov/pubmed/11807630
    http://www.ncbi.nlm.nih.gov/pubmed/10865985
    http://www.ncbi.nlm.nih.gov/pubmed/10641439
    http://www.ncbi.nlm.nih.gov/pubmed/9827941
    http://www.ncbi.nlm.nih.gov/pubmed/9177427
    https://www.glowm.com/pdf/Book-OvarianCancerTherapeutics-CC-BY-Ch13.pdf




    Neurological Health
    http://www.ncbi.nlm.nih.gov/pubmed/24108469
    http://www.ncbi.nlm.nih.gov/pubmed/23682563
    http://www.ncbi.nlm.nih.gov/pubmed/20092997
    http://www.ncbi.nlm.nih.gov/pubmed/19235890
    http://www.ncbi.nlm.nih.gov/pubmed/14704312

    Testosterone
    http://www.ncbi.nlm.nih.gov/pubmed/21914161
    http://www.ncbi.nlm.nih.gov/pubmed/21894328

    Estrogen
    http://www.ncbi.nlm.nih.gov/pubmed/15763078
     

    Attached Files:

  2. Tarmander

    Tarmander Member

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    Very nice. Would the place of topical application have different effects? I.e. Applying it to the jaw would give a "strengthening"/wider look?
     
  3. OP
    haidut

    haidut Member

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    I have not seen any studies on that, probably because not many scientists have thought of using vitamin K topically. However, I think that would be an interesting experiment. Another interesting one would be applying on the testicles or in that general area given the studies showing vitamin K directly stimulated testicle testosterone synthesis form precursors like pregnenolone and DHEA. So, a few drops of Pansterone and 1 drop of Kuinone may have an effect.
     
  4. milk_lover

    milk_lover Member

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    I placed an order and I can't wait for it to arrive :) I've been thinking of mk-4 all this time and I want to experiment with it. Thanks haidut!
     
  5. OP
    haidut

    haidut Member

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    Thanks for ordering. It will probably ship today. Please keep me posted on your results.
     
  6. milk_lover

    milk_lover Member

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    I will :)
     
  7. Tarmander

    Tarmander Member

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    Rub it on your balls dude and let us know
     
  8. milk_lover

    milk_lover Member

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    :lol: well that's a possibility! I have some ideas about mk-4, in the meantime I will go through the mk-4 posts on the site to educate myself more.
     
  9. Tarmander

    Tarmander Member

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    It is for SCIENCE man...reach for the stars
     
  10. Dan Wich

    Dan Wich Member

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    Congrats Haidut, this looks cool. I just wish you'd included a reference or two in your post :)
     
  11. hmac

    hmac Member

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    Amazing, thanks! Apologies if you have mentioned this elsewhere, but have you ever seen evidence to suggest depletion of other fat solubles by large doses of K2? I've heard this mentioned but never actually seen evidence for it.
     
  12. OP
    haidut

    haidut Member

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    I have seen evidence for large doses of vitamin E depleting vitamin K, not the other way around. But the dose of vitamin E was high and taken long term. It was equivalent to 2g for a human taken for 6 months. Not something very realistic, but the depletion of vitamin K by vitamin is thought to be the reason behind the negative effects in the clinical trials with vitamin E and prostate cancer.
    viewtopic.php?t=8569
     
  13. hmac

    hmac Member

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    Thanks, and I actually just saw that in the third study you have attached there is a possible mechanism for E's depletion of K but not the other way round.
     
  14. michael94

    michael94 Member

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    Haidut, have you posted before on the chemical similarities and implications between vitamin K and things like tetracycline? I know you mentioned it in one of the podcasts with Danny Roddy but I wanted to hear a bit more. If that's included in the references you posted I apologize but I did not find it.

    Edit: I looked a bit harder and found this from Haidut, it might be useful to others:

     
  15. zanolachino

    zanolachino Member

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    In terms of absorption, how would this MK-4 used transdermally compare with other MK-4 supplements taken orally (with adequate fat)?
     
  16. OP
    haidut

    haidut Member

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    Yeah you found it, and here is the quote form Peat:
    https://www.raypeatforum.com/forum/viewtopic.php?t=5151
    "...RP: There is a series that actually starts with vitamin K. It's a quinone structure that has been studied from about 1910 on as an anti-cancer, antiviral, energy-promoting, respiration-improving, anti-inflammatory, anti-fibrotic substance. For example, vitamin K is now used to strengthen bones, prevent osteoporosis and prevent calcification of arteries. That's a basic, vital function that does have tremendous range of functions. The emodin in cascara is a three-ring substance and the tetracycline is a four-ring substance, but they are all quinones that are intensified by adding the extra ring. So from vitamin K all the way up to tetracycline, it's a similar biological effect. It sounds too good to be true, to be able to stimulate respiration, be anti-inflammatory, germicidal, anti-cancer and so on."

    viewtopic.php?t=5419
    "...RP: If you put vitamin K and emodin and lapacho in a row and tetracycline (the antibiotic which is an anti-inflammatory), they're essentially the same structure with a different number of rings. But it's like each one is an analog of the other and each one has properties overlapping with those of the other — anti-inflammatory, anti-cancer, anti-stress."
     
  17. OP
    haidut

    haidut Member

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    It may have higher bioavailability and longer half-life.
     
  18. FredSonoma

    FredSonoma Member

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    Would Vitamin K have the same kind of beneficial effects on the intestines if taken topically rather than orally?
     
  19. OP
    haidut

    haidut Member

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    Noted, Dan. I am just responding to some comments I got through email that I am not including *enough* references in my supplements threads :shock:
    So... I thought this time I'd better address these concerns.
     
  20. honeybee

    honeybee Member

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    Haidut -if I'm using k2 for cleaning up a fatty liver how would the transdermal route work? I thought applying on skin bypassed the liver. Thx.
     
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