Ray Peat Interview KMUD August 20, 2021

rr1

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Starts at 4:00 minutes
 

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Lejeboca

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Dr. Peat mentions that iron catalyses lipid (auto)oxidation especially under stress when much PUFAs are released and red blood cells break faster.
As a followup. I digged out a packed study that shows that ceruloplasmin and associated with it copper inhibit lipid oxidation, contributing to serum's anti-oxidatnt properties if the blood is not loaded with ferrous and ferric salts and ascorbic acid.

The inhibition of lipid autoxidation by human caeruloplasmin.

Abstract: 1. Purified caeruloplasmin was shown to inhibit lipid autoxidation induced by ascorbic acid or inorganic iron in the following systems: (a) an emulsion of linolenic acid in water; (b) an untreated ox brain homogenate in phosphate buffer; (c) a similar homogenate whose susceptibility to autoxidation had been abolished by dialysis or by heating and then restored by the above pro-oxidants. 2. The optimum conditions for this antioxidant activity were studied. 3. Caeruloplasmin did not inhibit autoxidation by u.v. irradiation in dialysed or preheated homogenates. 4. The apoprotein (without copper) had no antioxidant activity, whereas CuSO4 alone was much less effective as an antioxidant. 5. Iron-free transferrin also had some antioxidant activity.

EDIT on interesting effect of table salt: "An increasing NaCl concentration between 50 and 300mM caused a near-linear decline in autoxidation in the control
homogenates from 10 to 8.4nmol of malonyldialdehyde/ml and a near-linear increase in the antioxidant activity of caeruloplasmin (1 g/litre) from 51 to 60 %"
 
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