I figured this would be the most chemistry-oriented forum to post in... Apparently, studies are showing that some break-down components of K are what are causing its antidepressant effects:
Metabolism of ketamine to (2R,6R)-HNK is necessary and sufficient to exert antidepressant actions. : NMDAR inhibition-independent antidepressant actions of ketamine metabolites : Nature : Nature Research
I see these available for purchase, but I'm wondering if you've any points for experimenters in terms of:
--dosage
--source
--specific antagonist
--other mechanisms the study might have missed
Metabolism of ketamine to (2R,6R)-HNK is necessary and sufficient to exert antidepressant actions. : NMDAR inhibition-independent antidepressant actions of ketamine metabolites : Nature : Nature Research
I see these available for purchase, but I'm wondering if you've any points for experimenters in terms of:
--dosage
--source
--specific antagonist
--other mechanisms the study might have missed
