Tristan Loscha
Member
- Joined
- Dec 18, 2018
- Messages
- 2,206
@Hans
They state that they were firm on Diet-control and mandated to consume
Diet according to a "menu plan"."To monitor dietary compliance, 24-h urine collections were
made at the beginning of the study (NSD)."(short term,these urine analyses are dependable imo,only around 5 percent
difference between intake and output).
"Dietary cards were recorded
throughout the study period."
But still not in a recorded controlled environment,but the effects were large.
Study design and protocol. The study was conducted
as a double-blind, randomized, crossover trial over
five consecutive weeks. All subjects entered the study on
their NSD (phase 1), after which they were randomly assigned
to either an HSD or an LSD for 2 wk (phase 2).
Thereafter, they followed a 1-wk washout period (phase 3)
on their NSD and then switched to the alternative diet for 2
wk (phase 4). All subjects were required to consume a base
diet of 1500 mg·d1 (65 mmol·L1·d1) of sodium and
approximately 2250 mg·d1 (64 mmol·L1·d1) of chloride,
which was provided by a menu plan, whether on the
LSD or HSD. For the HSD, the base diet was supplemented
with 10 1-g salt capsules per day comprising 4000 mg·d1
(174 mmolL1d1) of sodium, and approximately 6000
mg·d1 of chloride (169 mmol·L1·d1). For the LSD, the
base diet was supplemented in the same manner, but with
placebo (sucrose) tablets.
At the initial screening test on the NSD and at the end of
each 2-wk treatment phase, pulmonary function (PF) and
DLCO was assessed pre- and postexercise (PF: 1, 5, 20, 45,
75, 90, 105, and 120 min; DLCO: 10 and 25 min) (Fig. 1).
The screening test was conducted to screen all subjects for
the presence of EIA, as indicated by a more than 10%
decrease in postexercise FEV1 compared with preexercise
values. Each subject underwent collection of induced sputum
48 h before exercise to establish baseline values on the
respective dietary salt regimen, and at 1, 6, and 24 h after
each exercise challenge (Fig. 1). Twenty-four hours before
each exercise challenge at the end of each 2-wk treatment
period, subjects reported to the laboratory to have their
plasma volume measured using the Evans blue (EB) dilution
method (Fig. 1). Blood pressure measurements, using brachial
artery sphygmomanometry, were taken at the beginning
of the study and every third day of the treatment period.
Blood pressure was also measured pre- and postexercise. To
monitor dietary compliance, 24-h urine collections were
made at the beginning of the study (NSD), at the end of each
2-wk treatment period, and at the end of the washout period
(Fig. 1). Body mass was determined before exercise at
screening and at the end of each treatment period. At the end
of the 1-wk washout period, all subjects reported to the
laboratory to void additional urine and undergo further pre and
postexercise PFT, to verify that urinary electrolyte
balance and the degree of exercise-induced airway narrowing
had returned to baseline levels established at the beginning
of the study (NSD) (Fig. 1). Dietary cards were recorded
throughout the study period. In addition, all subjects
were asked to record bronchodilator use during each 2-wk
treatment period.
They state that they were firm on Diet-control and mandated to consume
Diet according to a "menu plan"."To monitor dietary compliance, 24-h urine collections were
made at the beginning of the study (NSD)."(short term,these urine analyses are dependable imo,only around 5 percent
difference between intake and output).
"Dietary cards were recorded
throughout the study period."
But still not in a recorded controlled environment,but the effects were large.
Study design and protocol. The study was conducted
as a double-blind, randomized, crossover trial over
five consecutive weeks. All subjects entered the study on
their NSD (phase 1), after which they were randomly assigned
to either an HSD or an LSD for 2 wk (phase 2).
Thereafter, they followed a 1-wk washout period (phase 3)
on their NSD and then switched to the alternative diet for 2
wk (phase 4). All subjects were required to consume a base
diet of 1500 mg·d1 (65 mmol·L1·d1) of sodium and
approximately 2250 mg·d1 (64 mmol·L1·d1) of chloride,
which was provided by a menu plan, whether on the
LSD or HSD. For the HSD, the base diet was supplemented
with 10 1-g salt capsules per day comprising 4000 mg·d1
(174 mmolL1d1) of sodium, and approximately 6000
mg·d1 of chloride (169 mmol·L1·d1). For the LSD, the
base diet was supplemented in the same manner, but with
placebo (sucrose) tablets.
At the initial screening test on the NSD and at the end of
each 2-wk treatment phase, pulmonary function (PF) and
DLCO was assessed pre- and postexercise (PF: 1, 5, 20, 45,
75, 90, 105, and 120 min; DLCO: 10 and 25 min) (Fig. 1).
The screening test was conducted to screen all subjects for
the presence of EIA, as indicated by a more than 10%
decrease in postexercise FEV1 compared with preexercise
values. Each subject underwent collection of induced sputum
48 h before exercise to establish baseline values on the
respective dietary salt regimen, and at 1, 6, and 24 h after
each exercise challenge (Fig. 1). Twenty-four hours before
each exercise challenge at the end of each 2-wk treatment
period, subjects reported to the laboratory to have their
plasma volume measured using the Evans blue (EB) dilution
method (Fig. 1). Blood pressure measurements, using brachial
artery sphygmomanometry, were taken at the beginning
of the study and every third day of the treatment period.
Blood pressure was also measured pre- and postexercise. To
monitor dietary compliance, 24-h urine collections were
made at the beginning of the study (NSD), at the end of each
2-wk treatment period, and at the end of the washout period
(Fig. 1). Body mass was determined before exercise at
screening and at the end of each treatment period. At the end
of the 1-wk washout period, all subjects reported to the
laboratory to void additional urine and undergo further pre and
postexercise PFT, to verify that urinary electrolyte
balance and the degree of exercise-induced airway narrowing
had returned to baseline levels established at the beginning
of the study (NSD) (Fig. 1). Dietary cards were recorded
throughout the study period. In addition, all subjects
were asked to record bronchodilator use during each 2-wk
treatment period.
