Ivermectin

Jing

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Would this be safe to take?
 

Sefton10

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Sefton10

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David PS

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Perry Staltic

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Level 14: Action on allosteric modulation of P2X4 receptor

P2X receptors are the channels selective to cation, are gated by extracellular ATP [61] and mediate several functions in health and disease [62]. From the seven subunits of P2X receptors, P2X4 is most sensitive to ivermectin. Positive allosteric modulation of P2X4 by ivermectin enhances ATP-mediated secretion of CXCL5 (proinflammatory chemokine). CXCL5 is a chemo-attractant molecule expressed in inflammatory cells in different tissues and modulates neutrophil chemotaxis and chemokine scavenging

Panax ginseng apparently has the same effect

We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allosteric modulators on P2X receptors. ATP-induced responses were measured in stable cell lines overexpressing human P2X4 using a YOPRO-1 dye uptake assay, intracellular calcium measurements, and whole-cell patch-clamp recordings. Ginsenosides CK and Rd were demonstrated to enhance ATP responses at P2X4 by ∼twofold, similar to potentiation by the known positive modulator ivermectin.

 
EMF Mitigation - Flush Niacin - Big 5 Minerals

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