Itching: Is It Your Kidneys?

Giraffe

Member
Joined
Jun 20, 2015
Messages
3,024
Peat said that too little calcium and vitamin D and too much phosphate lead to kidney degeneration, and supplementing those "in many cases will correct the whatever the liver and kidney problem is." [source]

I found a couple of studies that link itching (and a couple of other skin and nail abnormalities) to either kidney disease or low vitamin D levels. Sure there are other possible causes, but since it is so easy to correct low vitamin D levels and to increase calcium intake/decrease phosphorus intake, it's worth a try.

Idiopathic itch, rash, and urticaria/angioedema merit serum vitamin D evaluation: a descriptive case series.

Low vitamin D levels were defined as <32 ng/mL. People were treated with oral supplementation of vitamin D.
With vitamin D treatment 70% (40/57) had complete resolution of symptoms. Mean 25[OH]D for vitamin D responsive patients (16.8 ng/mL) was significantly lower than for vitamin D non-responsive treated patients (20.9 ng/mL, P = 0.02 by unpaired t-Test). Resolution of cutaneous symptoms with vitamin D supplementation occurred in a mean of 4.2 weeks. Symptom recurrence was seen in subsequent months only if vitamin D insufficiency recurred.


Skin and serum levels of calcium, phosphorus and vitamin D3 in uremic pruritus patients before and after broad band ultraviolet B (UVB) phototherapy

Here UVB phototherapy was used.
The study was carried out on 18 uremic patients having uremic pruritus and 9 healthy volunteers who served as controls. [...] Disappearance of itching occurred in all patients following UVB phototherapy.


Skin and nail abnormalities are found in most patients with chronic kidney disease.

Cutaneous abnormalities in patients with end stage renal failure on chronic hemodialysis. A study of 458 patients.
A total of 394/458 (86%) patients had cutaneous abnormalities. These included pruritus (56.6% of patients), paleness (60.7%), xerosis (52.8%), hyperpigmentation or hypopigmentation (38.4%), venous dilation near the fistula (22.2%), eczema in the fistula area (14.8%), half-and-half nails (13.5%), onychodystrophy (6.1%), subungual hemorrhage (4.5%), leukonychia (4.5%), stomatitis (5.6%), xerostomia (3.2%), gingivitis (2.4%), uremic breath (2.1%), and skin calcificatins (0.4%). Nephrogenic fibrosing dermopathy was not detected in any of our patients.
 

Daft

Member
Joined
May 1, 2016
Messages
74
I believe subclinical cholestasis, blocking of the bile duct, was a suspected cause in a study I read about "Pruritus with unknown origin". They found elevated TBSA levels. Sorry I can't find the study
 

michael94

Member
Joined
Oct 11, 2015
Messages
2,143
I believe subclinical cholestasis, blocking of the bile duct, was a suspected cause in a study I read about "Pruritus with unknown origin". They found elevated TBSA levels. Sorry I can't find the study
Yes. Kidneys suffer tremendously when bile is fully or partially blocked from leaving the liver. Cholestasis is not some unique case... it is a ubiquitous artifact of all health problems.

I wrote a bit about this a long time ago when I knew much less, but there is still some useful information in this post.
https://raypeatforum.com/community/...onstipation-antifungals-and-probiotics.12707/
 

EIRE24

Member
Joined
Apr 9, 2015
Messages
1,779
Peat said that too little calcium and vitamin D and too much phosphate lead to kidney degeneration, and supplementing those "in many cases will correct the whatever the liver and kidney problem is." [source]

I found a couple of studies that link itching (and a couple of other skin and nail abnormalities) to either kidney disease or low vitamin D levels. Sure there are other possible causes, but since it is so easy to correct low vitamin D levels and to increase calcium intake/decrease phosphorus intake, it's worth a try.

Idiopathic itch, rash, and urticaria/angioedema merit serum vitamin D evaluation: a descriptive case series.

Low vitamin D levels were defined as <32 ng/mL. People were treated with oral supplementation of vitamin D.



Skin and serum levels of calcium, phosphorus and vitamin D3 in uremic pruritus patients before and after broad band ultraviolet B (UVB) phototherapy

Here UVB phototherapy was used.



Skin and nail abnormalities are found in most patients with chronic kidney disease.

Cutaneous abnormalities in patients with end stage renal failure on chronic hemodialysis. A study of 458 patients.
That's strange. I suffer from bad kidney function and also acne. I wonder if these two things are linked?
 

EIRE24

Member
Joined
Apr 9, 2015
Messages
1,779

Giraffe

Member
Thread starter
Joined
Jun 20, 2015
Messages
3,024
I believe subclinical cholestasis, blocking of the bile duct, was a suspected cause in a study I read about "Pruritus with unknown origin". They found elevated TBSA levels. Sorry I can't find the study
Yes. Kidneys suffer tremendously when bile is fully or partially blocked from leaving the liver.


Low Serum Vitamin D Level Is Associated With Intrahepatic Cholestasis of Pregnancy
Conclusion: Our study suggests that low levels of 25(OH) Vit D3 were associated with ICP disease and its severity. However, further larger studies are needed to evaluate the effect of Vit D in the pathogenesis and outcome of the disease.
So vitamin D is low in people with cholestatis. It seems that there is no study that asked if vitamin D supplementation helps with cholestatis, but there are studies that found that vitamin D helps with pruritus (a symptom of cholestatis).
 
Similar threads
Thread starter Title Forum Replies Date
Mr Joe Skin Itching (Stress, Heat, Sun) Skin 0
Doludolu Feet Fingers Slight Redness, Itching, Joint Mild Pain - CAUSES? Symptoms, Causes 0
T Every Morning I Have A Histamine Reaction - Itching All Over - Before I've Eaten Or Done Anything Ask For Help or Advice 11
B What Have You Guys Tried To Stop Scalp Itching? Hair & Nails 45
J Itching From The Sun Ask For Help or Advice 0
T Self-diagnosing: If I Start Itching A Little After Eating X, Should I Eliminate It? Cortisol, Serotonin, Histamine 1
G T3 And Itching Thyroid and Hormones 0
G T3 And Itching Supplements, Pharmaceutical Drugs 0
M Why Does Malic Acid Get Rid Of My Scalp Itching? Ask For Help or Advice 6
M Success In Treating Chronic Urticaria + Itching + Dermotographia Testimonials 3
P Pruritus (itching) And Anxiety Ask For Help or Advice 8
haidut Itching May Be Driven By Serotonin Scientific Studies 24
E Potatoes And Itching Ask For Help or Advice 20
D Itching and burning Ask For Help or Advice 8
B Aspirin And Kidneys Supplements 7
T Regeneration Of The Kidneys - Something That Is Still Unresolved In Medicine Ask For Help or Advice 53
AlphaCog Neanderthals Had Enlarged Liver And Kidneys From Meat-Heavy Diet Discussing Dietary Models 55
M What Helps Kidneys To Filter Better? Ask For Help or Advice 50
Momado965 Offal Kidneys And Adrenals Diet 11
P Magnesium Bicarbonate Burdens My Kidneys And Urinary Bladder Magnesium 21
N Is Drinking More Fluids Really Benefitial For Helping Kidneys? Ask For Help or Advice 1
biggirlkisss Lituam Being Hard On Kidneys How True Is That? Ask For Help or Advice 1
Diokine Cigarette Smoking And The Kidneys Health 1
D Adrenals Direct Impact on Kidneys...? Ask For Help or Advice 4

Similar threads

Top