Amazoniac
Member
The following link is from a Trevor Marshall page shared by @LLight. Given the conditions, I was expecting something worse:
- Normal vitamin D levels can be maintained despite rigorous photoprotection: Six years' experience with xeroderma pigmentosum
- Normal vitamin D levels can be maintained despite rigorous photoprotection: Six years' experience with xeroderma pigmentosum
"Eight patients with XP were studied (four males and four females; mean age at beginning of the study, 27 years [range, 14-49 years]). They were all the participants in a study of the use of oral isotretinoin for skin cancer prevention.[7] They did not receive supplemental vitamin D or calcium and did not use oral contraceptives. Values of serum calcium, ionized calcium, 25-hydroxyvitamin D (25-OHD), and 1,25-dihydroxyvitamin D (1,25-[OH]2D) and PTH (intact) were assessed from 1989 through 1995. The patients lived throughout the United States from as far south as California to as far north as Wisconsin."
"All eight patients with XP utilized extreme sun protection measures by staying indoors during daylight hours, wearing sun-protective clothing, and applying sunscreens of at least sun protection factor (SPF) 15 each day. They reported daily sunlight exposure averaging 5 minutes or less. Several of the patients had a history of marked sun burning on minimal sun exposure before diagnosis of XE During the course of this study none experienced sunburning."
"The patients reported adequate dietary vitamin D with an estimated mean daily intake of 307 IU (range, 136 to 543 IU). The main source of dietary vitamin D was milk. Two patients reported vitamin D-deficient diets averaging 136 IU/day (patient 3) and 142 IU/day (patient 1). Patient 1 had the lowest mean value of serum 1,25-(OH)2D and had sporadic values at or below the lower limit of "n"or"m"al for both serum 25-OHD and 1,25-(OH)2D (Figs. 2 and 3). Patient 3 had serum vitamin D levels that were similar to other patients who reported a higher vitamin D intake."
"Low vitamin D levels may be compensated by increasing the levels of PTH. However, the mean intact PTH levels in the seven patients with XP tested was 36.1 ± 3.4 pg/ml ("n"or"m"al range, 10 to 65 pg/ml)."
"All eight patients with XP utilized extreme sun protection measures by staying indoors during daylight hours, wearing sun-protective clothing, and applying sunscreens of at least sun protection factor (SPF) 15 each day. They reported daily sunlight exposure averaging 5 minutes or less. Several of the patients had a history of marked sun burning on minimal sun exposure before diagnosis of XE During the course of this study none experienced sunburning."
"The patients reported adequate dietary vitamin D with an estimated mean daily intake of 307 IU (range, 136 to 543 IU). The main source of dietary vitamin D was milk. Two patients reported vitamin D-deficient diets averaging 136 IU/day (patient 3) and 142 IU/day (patient 1). Patient 1 had the lowest mean value of serum 1,25-(OH)2D and had sporadic values at or below the lower limit of "n"or"m"al for both serum 25-OHD and 1,25-(OH)2D (Figs. 2 and 3). Patient 3 had serum vitamin D levels that were similar to other patients who reported a higher vitamin D intake."
Killcidiol:
Killcitriol:
Killcitriol:
"Low vitamin D levels may be compensated by increasing the levels of PTH. However, the mean intact PTH levels in the seven patients with XP tested was 36.1 ± 3.4 pg/ml ("n"or"m"al range, 10 to 65 pg/ml)."