Hey all,
I am yet to personally experiment with 9-Methyl-β-carboline (9-MBC), but after reading about it's potential applications and benefits, I decided to make a YouTube video to discuss it's somewhat remarkable features.
Here is the entire video:
Some mechanisms of action I will post here, which you can find more in the video above:
•Protein and gene expression of tyrosine hydroxylase, as well as gene expression of tyrosine hydroxylase-relevant transcription factors (Nurr1, Pitx3, CREB, CREBBP, GATA2 and GATA3), was increased after 9-MBC treatment (11).
• Up-regulates, differentiates and protects dopaminergic neurons, dendrites and synapses, especially in the substantia nigra of the midbrain and in the hippocampus (1)(2)(6)(7)
• Increases dopamine synthesis (1)(7).
• Increases neurotrophins/neurotrophic factors (NGF, BDNF, CDNF [6], GDNF, SHH (5) and decrease apoptic signals (like caspase-3) (2)
• Decreases inflammation, preventing microglia proliferation and chemokine release [4], protecting against lipopolysaccharide toxicity (5) and reducing LDH (2)(6) (lactate dehydrogenase). Reduces α-synuclein (4)(5), the aggregation of which form insoluble fibrils (like lewy bodies), one of the causes of some neurodegenerative disorders, like PD and AD (alzheimer's disease)
• Increases TH (6) (tyrosine hydroxylase) expression and its transcription factors, and interacts with tyrosine kinases, TH converts L-tyrosine to L-Dopa, needed for the synthesis of the catecholamines, especially dopamine
• MAO-B inhibition (3), preventing the formation of neurotoxic substances, like DOPAC (from the dopamine metabolization), 6-OH-DA (oxydopamine), and MPDP⁺/MPP⁺ (from MPTP), the major cause of dopaminergic neurons death.
• Increases/protects/recovers the NADH dehydrogenase (or "complex I" (6) which catalyzes the transfer of electrons between NADH and Co-Q10), enhancing the mithocondrial respiration chain (7)
• Increase ATP (6)
Even when 9-MBC was administered chronically, it exerted no neurotoxic effects (11).
I am yet to personally experiment with 9-Methyl-β-carboline (9-MBC), but after reading about it's potential applications and benefits, I decided to make a YouTube video to discuss it's somewhat remarkable features.
Here is the entire video:
Some mechanisms of action I will post here, which you can find more in the video above:
•Protein and gene expression of tyrosine hydroxylase, as well as gene expression of tyrosine hydroxylase-relevant transcription factors (Nurr1, Pitx3, CREB, CREBBP, GATA2 and GATA3), was increased after 9-MBC treatment (11).
• Up-regulates, differentiates and protects dopaminergic neurons, dendrites and synapses, especially in the substantia nigra of the midbrain and in the hippocampus (1)(2)(6)(7)
• Increases dopamine synthesis (1)(7).
• Increases neurotrophins/neurotrophic factors (NGF, BDNF, CDNF [6], GDNF, SHH (5) and decrease apoptic signals (like caspase-3) (2)
• Decreases inflammation, preventing microglia proliferation and chemokine release [4], protecting against lipopolysaccharide toxicity (5) and reducing LDH (2)(6) (lactate dehydrogenase). Reduces α-synuclein (4)(5), the aggregation of which form insoluble fibrils (like lewy bodies), one of the causes of some neurodegenerative disorders, like PD and AD (alzheimer's disease)
• Increases TH (6) (tyrosine hydroxylase) expression and its transcription factors, and interacts with tyrosine kinases, TH converts L-tyrosine to L-Dopa, needed for the synthesis of the catecholamines, especially dopamine
• MAO-B inhibition (3), preventing the formation of neurotoxic substances, like DOPAC (from the dopamine metabolization), 6-OH-DA (oxydopamine), and MPDP⁺/MPP⁺ (from MPTP), the major cause of dopaminergic neurons death.
• Increases/protects/recovers the NADH dehydrogenase (or "complex I" (6) which catalyzes the transfer of electrons between NADH and Co-Q10), enhancing the mithocondrial respiration chain (7)
• Increase ATP (6)
Even when 9-MBC was administered chronically, it exerted no neurotoxic effects (11).
